Herbal Medicine as Neuroprotective Potential Agent in Human and Animal Models: A Historical Overview

Abstract

Neurodegenerative disorders could be a most important health issue within the 21st century. In the recent past; there has been a growing interest in medicinal plants. Chemical fruits and vegetables are said to decrease the possibility of many chief ailments, together with cardiovascular and cancer disorders as well as neurodegenerative ailments. Hence, who eat more fruits and vegetables may be less threaten for developing certain diseases caused by neurological dysfunction. The present review provides an overview of the about 14 most important plants used for neurological disorders and explores their neurological protection for the development of new pharmacological potential drugs. The data sources including the publications on Google Scholar, PubMed, and Science Direct. Publications searched with no particular time restriction in order to get a holistic and comprehensive view of the research done on this topic so far. Therefore, we present a systematic approach for herbal medicine as neuroprotective agent. From ancient time the herbal medicines are used to cure neurological symptoms. While the exact pharmacology of these herbs has not yet been set on, some of them have anti-inflammatory or antioxidant properties on different peripheral systems. The significant variety of medicinal plants makes it an essential source of healthy compounds compared to current therapeutic agents. In this review, the importance of phytochemicals for the function of neurological protection and other related disorders, in particular, the process mechanism and therapeutic prospective will be emphasize.

Applications of Phyto-Nanotechnology for the Treatment of Neurodegenerative Disorders

“…In the brain, glabridin decreases the MDA level, and increases the superoxide dismutase level while reducing glutathione levels. A study suggested that G. glabra administration restored the decreased concentration of dopamine and glutamate in the brain and decreased activity of AChE [72]. decreases the enzymatic leakage of lactate dehydrogenase, preserves cellular morphology, restores superoxide dismutase, and catalyses enzyme levels, thereby preventing neuronal damage [77].…”

Plant-Derived Metabolites as Potent Inhibitor and Treatment for COVID-19

“…that are highly studied and approved and they may be most reliable and useful. Second, utilizing natural anti-parasitic, antimicrobial, and anti-inflammatory medicines derived from plants, animals, and microbes (5,6). It has been concluded after studies that herbal medicines have efficiency in fighting against COVID-19 with activities in blocking the essential proteins for the life cycle of this virus (7).…”

Preventive Effects of Ginger Extract and Nigella sativa Oil on Anxiety and Depression Behavior in Wistar Rats Exposed to Mercuric Chloride

“…The high antioxidant activity of ginger is due to the polyphenolic 6-gingerol compounds and its derivatives contained in these roots. [7] Another commonly used plant, Nigella sativa is a medicinal herb used for antioxidant activity. In rats, Nigella sativa seeds also play an important role in the lack of spatial cognition caused by chronic cerebral hypoperfusion.…”