Effect of Anti‐Infective Mechanical Therapy on Clinical Parameters and Cytokine Levels in Human Peri‐Implant Diseases

Duarte, Poliana Mendes; Mendonça, Adriana Cutrim de; Máximo, Maria Beatriz Braz; Santos, Vanessa Renata; Bastos, Marta Ferreira; Nociti, Francisco Humberto

doi:10.1902/jop.2009.070672

Cited by 99 publications

(145 citation statements)

References 43 publications

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“…Similar to findings in GCF obtained from sites with periodontitis (Belibasakis and Bostanci 2012), there is increasing evidence showing the association of the receptor activator of nuclear factor kappaB ligand (RANKL) -osteoprotegerin (OPG) system with the occurrence and severity of periimplantitis (Arikan et al 2008;Arikan et al 2011;Sarlati et al 2010;Guncu et al 2012;Duarte et al 2009a;Duarte et al 2009b;Rakic et al 2013). A few studies looking into other markers of bone metabolism, such as osteocalcin, reported that these are higher in PICF from peri-implant mucositis compared to healthy sites, whereas no differences were observed between periimplatitis and either mucositis or health.…”

mentioning

confidence: 74%

“…In line with previous findings, there were no differences with regards to IL-6, IL-8, IL-10 (Severino et al 2011), whereas the levels of IL-1β were significantly higher at peri-implantitis, compared to mucositis sites. Further studies also showed that peri-implantitis treatment reduced the PICF levels of IL-1β (Bassetti et al 2013) and TNF-α (de Mendonca et al 2009;Duarte et al 2009a). Studies have also demonstrated that single nucleotide polymorphisms (SNP) in the IL-1 gene may hold an increased risk for the development of peri-implantitis, particularly when combined with smoking (Andreiotelli et al 2008;Bormann et al 2010).…”

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confidence: 93%

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Peri-Implant Infections of Oral Biofilm Etiology

Belibasakis

Charalampakis

Bostancı

et al. 2014

Advances in Experimental Medicine and Biology

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Biofilms are complex microbial communities that grow on various surfaces in nature. The oral micobiota tend to form polymicrobial biofilms, particularly on the hard mineralized surfaces of teeth, which may impact on oral health and disease. They can cause inflammation of the adjacent tooth-supporting (periodontal) tissues, leading to destructive periodontal disease and tooth loss. The emergence of osseointegrated dental implants as a restorative treatment option for replacing missing teeth has also brought along new artificial surfaces within the oral cavity, on which oral bacteria can form biofilms. As in the case of natural teeth, biofilms on implant surfaces may also trigger infection and cause inflammatory destruction of the peri-implant tissue (i.e. peri-implantitis). While there are strong similarities in the composition of the mixed microbial flora between periodontal and peri-implant infections, there are also a few distinctive differences. The immunological events underlying the pathogenesis of peri-implant infections are qualitatively similar, yet more extensive, compared to periodontal infections, resulting in a faster progression of tissue destruction. This chapter summarizes the current knowledge on the microbiology and immunology of peri-implant infections, including findings from the peri-implant crevicular fluid, the inflammatory exudate of the peri-implant tissue. Moreover, it discusses the diagnosis and current approaches for the treatment of oral infections.

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confidence: 74%

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confidence: 93%

Peri-Implant Infections of Oral Biofilm Etiology

Belibasakis

Charalampakis

Bostancı

et al. 2014

Advances in Experimental Medicine and Biology

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“…In contrast, Duarte et al (8) o�served no differences �etween healthy su�jects and patients with disease. In another study, Duarte et al (11) evaluated the efficacy of e520 mechanical treatment for mucositis and periimplantitis. An improvement in the clinical parameters was noted, together with improvement in the levels of TNF-α and the OPG/RANKL ratio three months after such treatment, without differences in the levels of IL -10 and IL-12.…”

Section: Influence Of Interleukins 6 8 10 and 12 Upon Periimplant Imentioning

confidence: 99%

Interleukins IL-6, IL-8, IL-10, IL-12 and periimplant disease. An update

et al. 2011

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“…Briefly, herpes viruses is recognized by Toll-like 2 receptors similarly as periopathogens that further induces release of cytokines, such as interleukin 1b and tumor necrosis factor α via nuclear factor-kappa B transcription factor 21 that have been previously reported to be associated with PI. 22,23 Such an increase in proinflammatory cytokines might further increase receptor activator nuclear factor kappa-B ligand levels and, subsequently, enhance inflammatory osteoclastogenesis. However, considering the extremely high prevalence in population of HSV-1 and the absence of correlation between HSV-1 and clinical parameters, it seems that the only presence of HSV-1 cannot be considered as a specific indicator of PI.…”

Section: Discussionmentioning

confidence: 99%

Herpes Simplex 1 and Periopathogen Role in Peri-implantitis

Parthiban

Ahmed

Ramakrishnan

et al. 2017

The Journal of Contemporary Dental Practice

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Introduction:The objectives of this study were to compare the qualitative and quantitative profiles of herpes simplex virus type I (HSV-1) in implant surfaces between participants with periimplantitis (PI) and Healthy peri-implant tissues and to quantitatively assess the relation between HSV-1 and periopathogens inside the microbiological profile associated with PI. Materials and methods:A total of 40 patients with PI and 40 with healthy peri-implant tissues (HI) were recruited. Plaque samples from peri-implant sulcus and internal implant connections were analyzed using quantitative real-time polymerase chain reaction to detect and quantify HSV-1 and periodontopathogens. Frequencies of detection and levels of microorganisms were compared between PI and HI; the frequencies and levels of periodontopathogens were compared between HSV-1+ and HSV-1− PI to assess qualitative relations between HSV-1 and bacteria. Correlation between HSV-1 and periodontopathogens levels was assessed in PI and HI.Results: A total of 77 dental implants affected by PI, and 113 HIs were included. The HSV-1 prevalence was slightly higher in PI compared with controls (33.3 vs 23.8%; p > 0.05); HSV-1 was detected in external samples more frequently compared with internal samples. The HSV-1-positive patients revealed higher median loads of Prevotella intermedia (Pi) and Campylobacter rectus (Cr) compared with HSV-1-negative patients. In the PI group, a significant positive correlation was evidenced between HSV-1 and Tannerella forsythia, Parvimonas micra (Pm), Fusobacterium nucleatum, and Cr levels, while in the HI, positive correlation between HSV-1 and Aggregatibacter actinomycetemcomitans, Pi, and Pm was established. Conclusion:The HSV-1 prevalence cannot be used to identify PI. The HSV-1 was found in similar levels of PI and HI patients after an average of 6 years of loaded implants. The HSV-1 prevalence cannot be used to identify implants with or without the presence of PI. HerpesClinical significance: Although HSV-1 is detected in PI site, HSV-1 may represent an unspecific indicator for the host response to the bacterial challenge observed in PI.

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Effect of Anti‐Infective Mechanical Therapy on Clinical Parameters and Cytokine Levels in Human Peri‐Implant Diseases

Abstract: The proposed anti-infective therapies may locally modulate the levels of TNF-alpha and the OPG/RANKL ratio and improve clinical parameters around peri-implant tissues.

Cited by 99 publications

References 43 publications

Peri-Implant Infections of Oral Biofilm Etiology

Peri-Implant Infections of Oral Biofilm Etiology

Interleukins IL-6, IL-8, IL-10, IL-12 and periimplant disease. An update

Herpes Simplex 1 and Periopathogen Role in Peri-implantitis

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