Peri-Implant Infections of Oral Biofilm Etiology

Belibasakis, Georgios N.; Charalampakis, Georgios; Bostancı, Nagihan; Stadlinger, Bernd

doi:10.1007/978-3-319-11038-7_4

Cited by 104 publications

(101 citation statements)

References 113 publications

(126 reference statements)

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“…1,2 Peri-implantitis is usually preceded by the accumulation of a polymicrobial biofilm within the peri-implant crevice, which can cause the inflammation of the adjacent tissues, bone loss and subsequent implant failure. 3 Removal of bacteria can resolve the soft-tissue inflammation, but, once the lesion invades bone, reversal capabilities are lost. 4 Preventive measures aiming primarily at discouraging biofilm formation have been proposed following various approaches.…”

Section: Introductionmentioning

confidence: 99%

Antibiofilm activity of sandblasted and laser-modified titanium against microorganisms isolated from peri-implantitis lesions

Drago

Bortolin

Vecchi

et al. 2016

Journal of Chemotherapy

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Infections due to biofilm-producing microorganisms are one of the main causes for the failure of dental implants. Increasing efforts have been made in order to develop new strategies to prevent biofilm formation. In this study, the biofilm development on a newly designed laser-modified titanium implant surface was evaluated and compared to that on conventional sandblasted titanium used in implant dentistry. The amount of biofilm produced by Staphylococcus aureus, Pseudomonas aeruginosa and Porphyromonas gingivalis isolated from peri-implantitis was assessed by a semi-quantitative spectrophotometric method and by confocal laser scanning microscopy. Results showed a lower biofilm production on laser-modified surface compared to the sandblasted one. In particular, a significantly lower total volume of the biomass was observed on laser-modified surface, while no significant changes in live/dead bacteria percentages were noticed between materials. Modifying the topography of the conventional implant surface with laser ablation could represent a promising approach for inhibiting biofilm formation.

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Section: Introductionmentioning

confidence: 99%

Antibiofilm activity of sandblasted and laser-modified titanium against microorganisms isolated from peri-implantitis lesions

Drago

Bortolin

Vecchi

et al. 2016

Journal of Chemotherapy

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“…tribute to the development of various oral diseases such as dental caries, gingivitis, periodontitis, and peri-implantitis [Rosier et al, 2014;Belibasakis et al, 2015;Arweiler and Netuschil, 2016]. Prevention of these diseases is therefore aimed at the efficient removal and subsequent reduction of dental plaque, in order to maintain oral health.…”

mentioning

confidence: 99%

Phytosphingosine Prevents the Formation of Young Salivary Biofilms in vitro

Bikker¹,

Hoogenkamp

Malhaoui³

et al. 2017

Caries Res

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Dental biofilms are formed in a multistep process that is initiated by the adhesion of oral bacteria to the dental hard surface. As dental biofilms are associated with oral diseases their control is necessary in order to maintain oral health. Recently, it was revealed that phytosphingosine (PHS)-treated hydroxyapatite discs showed anti-adhesive activity in a static in vitro biofilm model against Streptococcus mutans. The goal of the present study was to further unravel the anti-adhesive and anti-biofilm properties of PHS in both static and dynamic in vitro biofilm models against a full salivary inoculum. After 3 h under static conditions, bacterial adherence on PHS-treated cover glass slides was reduced by 60% compared to the untreated surface. After 6 and 24 h under static conditions, no significant differences in bacterial adherence were observed between PHS-treated and untreated cover glass slides. However, under dynamic conditions, i.e., the presence of shear forces, virtually no bacterial adherence was observed for up to 16 h on PHS-coated surfaces. Besides, PHS showed a strong bactericidal activity on salivary biofilms. Treatment of a 3- and 6-h statically grown biofilm resulted in a 99 and 94% reduction of viable cells, respectively, which was effectuated within minutes. In principle, these anti-adherence and anti-biofilm properties make PHS a promising candidate ingredient for use in oral care products aimed at oral microbial control.

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“…In human infections they are found on many implants but also on teeth [2] or the mucosa, e. g. in the cystic fibrosis lung [3], the skin [4] or the middle ear [5]. These aggregates are structurally complex, dynamic systems with a multitude of interactions between the community members and the host [6].…”

Section: Pathogens Organized In Biofilms Are Difficult To Eradicatementioning

confidence: 99%

cis-2-Alkenoic Acids as Promising Drugs for the Control of Biofilm Infections

Yuyama¹,

Abraham

2016

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Microbes attached to surfaces and form biofilms where they are difficult to eradicate. Here they are embedded in a complex matrix of polymers and are much less sensitive against antibiotics or the immune system. This is a growing problem, especially for implants; hence, novel approaches are urgently needed to control biofilm infections. Many of these approaches interfere with the communication between the microbial cells required for biofilm formation and maintenance, a process known as quorum sensing. But microbes have also several mechanisms to disperse their own biofilms if conditions become unfavourable. Recently, it has been found that the pathogen Pseudomonas aeruginosa disperses its mature biofilms using cis-2-decenoic acid. This fatty acid belongs to a group of cis-2-alkenoic acids which are known from several bacteria and are also triggering the communication between different species. In this review the biosynthesis of these compounds, their signal transduction and their role in species-species communication are presented. Examples are discussed where cis-2-alkenoic acids have been used to eradicate biofilms and enhance the sensitivity of pathogens against antibiotics, either alone or in combination with antibiotics. Although this presents an interesting approach for the control of biofilm infections it is still in its infancy and a much broader characterization of the effects of cis-2-alkenoic acids are needed before moving to any medical application.Keywords: biofilm, quorum-sensing, diffusible signal factor (DSF), quorum-quenching, host-pathogen interaction, cis-2-alkenoic acids, antibiotics 1 Pathogens organized in biofilms are difficult to eradicateMicroorganisms can attach to surfaces where they form biofilms, microbial aggregates embedded in a complex and structured matrix of polymers [1]. In human infections they are found on many implants but also on teeth [2] or the mucosa, e. g. in the cystic fibrosis lung [3], the skin [4] or the middle ear [5]. These aggregates are structurally complex, dynamic systems with a multitude of interactions between the community members and the host [6]. Biofilm formation is a key factor for the survival of microbes but biofilms have also the ability to disperse under unfavourable conditions to colonize new niches [7]. Biofilm infections cause many deaths and high health costs worldwide, e. g. in the U. S. alone 32% of all healthcare-associated infections are urinary tract infections, 22% are surgical site infections and 14% are blood stream infections causing costs between $5000 and $34,000 per infection and summing up to more than $5 billion in added medical costs per annum [8].The main problem comes not so much from the human pathogens causing the infections but from their organization in biofilms. Biofilm are formed for the protection of the cells against hostile environmental conditions. As a consequence, biofilm infections are difficult to eradicate because of much better protection against antibiotics compared to free living cells [9]. It has been...

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Peri-Implant Infections of Oral Biofilm Etiology

Cited by 104 publications

References 113 publications

Antibiofilm activity of sandblasted and laser-modified titanium against microorganisms isolated from peri-implantitis lesions

Antibiofilm activity of sandblasted and laser-modified titanium against microorganisms isolated from peri-implantitis lesions

Phytosphingosine Prevents the Formation of Young Salivary Biofilms in vitro

cis-2-Alkenoic Acids as Promising Drugs for the Control of Biofilm Infections

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