Effect of a 12-week walking exercise program on body composition and immune cell count in patients with breast cancer who are undergoing chemotherapy

Kim, Ji Jeong; Shin, Yun A; Suk, Min Hwa

doi:10.5717/jenb.2015.19.3.255

Cited by 4 publications

(5 citation statements)

References 47 publications

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“…Leucocyte complexity indirectly provides insight into breast cancer survival [30] and can be modulated by exercise [31]. Our unchanged total leucocyte count during Intervention study and Follow-up was also observed in a study by Kim et al, where the effect of a 12-week walking exercise on the immune cells was examined [32] which is in accordance with our neopterin data. The experimental values in IG in leucocyte count was also accompanied by a significantly decreased and presumably beneficial hsCRP response.…”

Section: Discussionsupporting

confidence: 91%

Two-year follow-up after a six-week high-intensity training intervention study with breast cancer patients: physiological, psychological and immunological differences

Schulz

Schümann

Otto

et al. 2021

Disability and Rehabilitation

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Section: Discussionsupporting

confidence: 91%

Two-year follow-up after a six-week high-intensity training intervention study with breast cancer patients: physiological, psychological and immunological differences

Schulz

Schümann

Otto

et al. 2021

Disability and Rehabilitation

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“…The exercise intensity in our study is substantially lower compared to the above-mentioned study, which might explain why we did not find significant change in CD14 + CD16 − monocytes and that the increase in CD14 + CD16 + monocytes was lower in our study (51% in our study versus 121% in Khosravi et al 15 . Moreover, it seems that chronic exercise does not change the immune cell counts in breast cancer patients 16 or survivors 15 . The mobilization induced by acute exercise appears to be transient, as also noticed in the present study.…”

Section: Discussionmentioning

confidence: 97%

“…However, it is widely accepted that findings in healthy individuals can not be generalized to diseased states, such as cancer. In breast cancer patients, the effect of exercise has been examined during and after cancer treatments 15 , 16 . However, to the best of our knowledge there are no studies investigating the effects of acute exercise on immune cell counts in breast cancer patients before the start of cancer treatments.…”

Section: Introductionmentioning

confidence: 99%

The effect of acute exercise on circulating immune cells in newly diagnosed breast cancer patients

Koivula

Lempiäinen

Rinne

et al. 2023

Sci Rep

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The role of exercise in cancer prevention and control is increasingly recognized, and based on preclinical studies, it is hypothesized that mobilization of leukocytes plays an important role in the anti-tumor effect. Thus, we examined how 10-min acute exercise modulates immune cells in newly diagnosed breast cancer patients. Blood samples were taken at rest, immediately after exercise and 30 min after exercise and phenotypic characterization of major leukocyte subsets was done using 9-color flow cytometry. Total leukocyte count increased by 29%, CD8+ T cell count by 34%, CD19+ B cell count by 18%, CD56+CD16+ NK cell count by 130%, and CD14+CD16+ monocyte count by 51% immediately after acute exercise. Mobilization of CD45+, CD8+, CD19+, and CD56+CD16+ cells correlated positively with exercising systolic blood pressure, heart rate percentage of age predicted maximal heart rate, rate pressure product, and mean arterial pressure. Our findings indicate that a single bout of acute exercise of only 10 min can cause leukocytosis in breast cancer patients. Mobilization of leukocytes appear to be directly related to the intensity of exercise. It is possible that the positive effect of exercise on oncologic outcome might be partly due to immune cell mobilization as documented in the present study.

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“…Regarding immune cell function, NK cell cytotoxicity was increased in two studies (86,109) and unchanged in two studies (96,115), lymphocyte proliferation was increased in two studies (86,90), and lymphocyte cytokine production was reported in four studies with mostly no change (83,86,90,105). When comparing post-PA intervention to pre-intervention, one study reported a reduction in the percentage of lymphocytes and monocytes and an increase in granulocytes (98), while two other studies reported no change in the percentage of T cells or NK cells (93,97). One study reported increased NK cell cytotoxicity post PA intervention (97).…”

Section: Clinical Findingsmentioning

confidence: 96%

“…Therefore, we classified the included studies into three categories: PA interventions given before, during, and after treatment. The existing evidence base only includes two pre-treatment (pre-surgical)(94,113) and eight duringtreatment(93,95,101,110,114,115,117,119) PA studies, while the majority of studies (n=27) assessed the effect of PA interventions post-cancer treatment.Most included studies assessed the effect of PA intervention on serum immune and inflammatory cytokines, the majority of which reported null results(83,85,(87)(88)(89)(90)(91)(92)94,99,100,102,103,105,108,110,(115)(116)(117)119). Several studies also compared post-PA intervention to pre-PA intervention serum cytokine levels, with mixed results showing either a reduction…”

mentioning

confidence: 99%

Impact of physical activity and energy restriction on immune regulation of cancer

Xu¹,

Rogers²

2020

Transl Cancer Res TCR

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Cancer is a major public health issue worldwide. Lifestyle factors, such as body weight and physical activity (PA), significantly impact cancer risk and progression. There is strong evidence that PA reduces and obesity increases risk and mortality from numerous cancer types. Energy restriction (ER) in non-obese hosts significantly reduces tumor incidence in a variety of preclinical models, and reduces body weight and cardiometabolic risk factors in humans. Emerging data suggest that PA-and ER-induced changes in inflammatory and immune mediators may contribute to the cancer prevention effects of these interventions. A systematic literature search was conducted to identify studies that evaluated the impact of PA and ER on tumor and immune outcomes in humans and animal models. A total of 97 eligible studies were identified (68 studies reporting PA interventions and 30 studies reporting ER interventions). Thirtyone studies investigated the effect of PA on cancer immune outcomes using preclinical cancer models of breast (n=17, 55%), gastrointestinal (n=6, 19%), melanoma (n=4, 13%), and several other cancer types (n=4, 13%). Despite the heterogeneity in study designs, the majority of studies (n=23, 74%) reported positive effects of PA on tumor outcomes. Thirty-seven clinical studies investigated the effect of PA on cancer immune outcomes. None reported tumor outcomes, thus only immune outcomes were evaluated in these studies. PA studies were conducted in patients with breast (n=22, 59%), gastrointestinal (n=5, 14%), prostate (n=2, 5%), esophageal (n=1, 3%), lung (n=1, 3%) cancer, leukemia (n=1, 3%), or mixed cancer types (n=5, 14%). Twenty-two studies investigated the effect of ER interventions on cancer immune outcomes using preclinical cancer models including breast (n=5, 23%), gastrointestinal (n=5, 23%), lung (n=2, 9%), liver (n=2, 9%), pancreatic (n=2, 9%), and several other cancer types (n=6, 27%). Positive effects of ER on tumor outcomes were reported in 21 of 22 studies. Six clinical studies investigated the effect of ER (in combination with PA) on tumor immune outcomes in cancer patients with overweight or obesity. Five were conducted in breast cancer patients, and one recruited patients of a mix of cancer types. A wide range of immunological parameters including immune cell phenotype and function, cytokines, and other immune and inflammatory markers were assessed in multiple tissue compartments (blood, spleen, lymph nodes and tumor) in the included studies. Results from preclinical and clinical studies suggest that both PA and ER exert heterogeneous effects on circulating factors and systemic immune responses. PA + ER alters the gene expression profile and immune infiltrates in the tumor which may result in a reduction in immune suppressive factors. However, additional studies are needed to better understand the effect of PA and/or ER on immunomodulation, particularly in the tumor microenvironment (TME).

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Effect of a 12-week walking exercise program on body composition and immune cell count in patients with breast cancer who are undergoing chemotherapy

Cited by 4 publications

References 47 publications

Two-year follow-up after a six-week high-intensity training intervention study with breast cancer patients: physiological, psychological and immunological differences

Two-year follow-up after a six-week high-intensity training intervention study with breast cancer patients: physiological, psychological and immunological differences

The effect of acute exercise on circulating immune cells in newly diagnosed breast cancer patients

Impact of physical activity and energy restriction on immune regulation of cancer

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