Efek Imunomodulator Infusa Umbi Bawang Dayak (Eleutherina palmifolia L. Merr) Dengan Metode Bersihan Karbon

Muthia, Rahmi; Astuti, Karunita Ika

doi:10.20527/jps.v5i1.5787

Cited by 5 publications

(4 citation statements)

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“…7 Imunomodulator adalah senyawa yang digunakan untuk memengaruhi sistem kekebalan tubuh dan memiliki kemampuan untuk meningkatkan respon kekebalan tubuh atau respon perlindungan terhadap suatu patogen. 8 Imunomodulator dapat diklasifikasikan menjadi 3 kelompok, yaitu imunostimulator yang memiliki peran untuk meningkatkan fungsi dan aktivitas dari sistem imun, imunoregulator yang berfungsi untuk meregulasi sistem imun, dan imunosupresor yang memiliki peran untuk menghambat atau menekan aktivitas dari sistem imun. 9 Terdapat banyak senyawa yang dapat berperan sebagai imunomodulator, termasuk mikronutrien.…”

Section: Pendahuluanunclassified

Correlation between Serum Level of Vitamin D and Covid-19 Infection Severity: A Literature Review

Wulansari

Tsani

Prasetya³

2022

Indones J Clin Pharm

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In recent years, infectious diseases caused by viruses have become one of the biggest global health problems, including coronavirus disease 2019 (Covid-19) infection. Covid-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can induce immune responses and inflammatory reactions, thereby leading to the damage of tissues. Hyperinflammation due to cytokine storm in infected patients increases the risk of severe infection and death. Vitamin D can also reduce the severity of infections because it acts as an immunomodulator. Therefore, this study aimed to determine the immunomodulatory effect of vitamin D on Covid-19 infections. A total of nine articles were collected using literature searching on several databases, such as PUBMED and Science Direct with the keywords of “Covid-19”, “immunomodulator”, and “vitamin D”. Five of them were observational or retrospective studies, which determined the correlation between serum concentration of vitamin D and Covid-19 infection severity. Meanwhile, another four articles were random clinical trials testing the effect of the drugs’s supplementation on infected people. The results showed that high levels of serum vitamin D can cause low concentrations of pro-inflammatory cytokines, which reduces the incidence of acute respiratory infections and the severity of the viral infection. Furthermore, vitamin D, specifically D3, has the potential to act as an immunomodulator in Covid-19 by reducing pro-inflammatory cytokines, thereby reducing the risk of severity.

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Section: Pendahuluanunclassified

Correlation between Serum Level of Vitamin D and Covid-19 Infection Severity: A Literature Review

Wulansari

Tsani

Prasetya³

2022

Indones J Clin Pharm

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“…In the Dayak onion plant (Eleutherine bulbosa (Urb.) the part that can be used is the tuber, which is known to have several activities, including antibacterial (Tazkiyatul Firdaus, 2014), immunomodulatory (Muthia & Astuti, 2018), anticancer (Muti'ah et al, 2020, and inflammation (Nataline, 2021).…”

Section: Introductionmentioning

confidence: 99%

A Phytochemical Characterization and Screening Test of Simplisia and Sabrang Garlic (Eleutherine bulbosa (Mill.) Urb.) Tuber Extract

Yanti¹,

Kurniasari²,

Hutahaean³

2022

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Sabrang onion (Eleutherine bulbosa (Mill.) Urb.) has been used for generations for various diseases such as breast and colon cancer, hypertension, diabetes mellitus, hypercholesterolemia and stroke. This study aims to determine the characterization and phytochemical screening of simplicia and sabrang onion bulb extract. Extracts were made by graded maceration using solvents based on their polarity levels, n-hexane, ethylacetate and ethanol as well as phytochemical screening and characterization of simplicia and extracts. The results of simplicia characterization, sabrang onion n-hexane extract (ENBS), sabrang onion ethylacetate extract (EEABS) and sabrang onion ethanol extract (EEBS) obtained water content of 8.64%, respectively; 4.98%; 8.27% and 9.11%; water soluble extract content of 8.52%; 1.12%; 9.51% and 72.19%; ethanol soluble extract content of 14.05%; 2.28%; 49.26% and 81.66%; total ash content 2.89%; 0.34%; 0.43% and 1.73% and the acid insoluble ash content is 0.59%; 0.06%; 0.07% and 0.20%. The results of the phytochemical screening of simplicia and extracts obtained groups of alkaloids, flavonoids, glycosides, saponins, anthraquinone glycosides, tannins and triterpenoids/steroids.

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“…This plants contained secondary metabolites such as phenols, flavonoids, saponins, alkaloids, tannins and quinones 4,5 . Bulbs of this plant had many activites such as immunomodulator [6][7][8] , antiinflamation 9 , antioxidant 10 , antihypertention 11 , antyhipercholesterol 4,12 and anticancer 13 .…”

Section: Introductionmentioning

confidence: 99%

Standardization of Eleutherine bulbosa Urb. Bulbs and Total Flavonoid Content from Three Locations in Kalimantan, Indonesia

Muthia¹,

Wati²,

Jamaludin³

et al. 2021

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Background: Dayak Onion (Eleutherine bulbosa Urb.) is a typical plant of Kalimantan which is traditionally used by the Dayak community as a medicinal plant. Dayak onion bulbs have been proven had many pharmacology activities. Objective: This study aims to determine the nonspesific and specific parameters of 70% ethanol extract of Eleutherine bulbosa Urb. Total flavonoids was also quantified Methods:. Eleutherine bulbosa Urb was extracted with maseration method used etanol 70 % as solvent. Determination of non-spesific includes by determined specific gravity, water content, total ash content, acid insoluble ash content, residual sovents, heavy metanol contamination, microbial contamination, mold and yeast contamination. Determination of specific parameters included extract identity, organoleptic extract, water/ethanol soluble content, chromatography profile. Total flavonoid content were quantified with colorimetric method. Results: there were no significance difference between nonspesific and specific parameters Eleutherine bulbosa Urb from three different locations. Measurement of total phenol content and total flavonoid content respectively form South Borneo were ; 6,499 ± 0,5248 mg QE/g extract, from central borneo were 7,585 ± 0,0437 mgQE/g extract, and from east borneo were 5,035 mg ± 0,3887 mgQE/g extract. Conclusion: it can be concluded that bulbs of Eleutherine bulbosa Urb from three locations have characters to similar between each other and bulbs of Eleutherine bulbosa Urb form central borneo had the highest total flavonoid content.

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Efek Imunomodulator Infusa Umbi Bawang Dayak (Eleutherina palmifolia L. Merr) Dengan Metode Bersihan Karbon

Cited by 5 publications

References 0 publications

Correlation between Serum Level of Vitamin D and Covid-19 Infection Severity: A Literature Review

Correlation between Serum Level of Vitamin D and Covid-19 Infection Severity: A Literature Review

A Phytochemical Characterization and Screening Test of Simplisia and Sabrang Garlic (Eleutherine bulbosa (Mill.) Urb.) Tuber Extract

Standardization of Eleutherine bulbosa Urb. Bulbs and Total Flavonoid Content from Three Locations in Kalimantan, Indonesia

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