Standardization of Eleutherine bulbosa Urb. Bulbs and Total Flavonoid Content from Three Locations in Kalimantan, Indonesia

Abstract

Background: Dayak Onion (Eleutherine bulbosa Urb.) is a typical plant of Kalimantan which is traditionally used by the Dayak community as a medicinal plant. Dayak onion bulbs have been proven had many pharmacology activities. Objective: This study aims to determine the nonspesific and specific parameters of 70% ethanol extract of Eleutherine bulbosa Urb. Total flavonoids was also quantified Methods:. Eleutherine bulbosa Urb was extracted with maseration method used etanol 70 % as solvent. Determination of non-spesific includes by determined specific gravity, water content, total ash content, acid insoluble ash content, residual sovents, heavy metanol contamination, microbial contamination, mold and yeast contamination. Determination of specific parameters included extract identity, organoleptic extract, water/ethanol soluble content, chromatography profile. Total flavonoid content were quantified with colorimetric method. Results: there were no significance difference between nonspesific and specific parameters Eleutherine bulbosa Urb from three different locations. Measurement of total phenol content and total flavonoid content respectively form South Borneo were ; 6,499 ± 0,5248 mg QE/g extract, from central borneo were 7,585 ± 0,0437 mgQE/g extract, and from east borneo were 5,035 mg ± 0,3887 mgQE/g extract. Conclusion: it can be concluded that bulbs of Eleutherine bulbosa Urb from three locations have characters to similar between each other and bulbs of Eleutherine bulbosa Urb form central borneo had the highest total flavonoid content.

Anti-Rheumatoid Arthritis Activity of 96% Ethanol Extract of Eleutherine bulbosa Bulbs with Arthritis Induction Adjuvant Method

“…Next, the sample was chopped and left dry in the sun with a black cloth covering it. Then, the sample was sorted again, mashed, and sieved using a no.40 mesh 16 .…”

Pemberdayaan Kelompok Wanita Tani Sri Rejeki pada Pengolahan Sediaan Umbi Bawang Dayak (Eleutherine bulbosa Urb.)

“…Terdapat pula bentuk penelitian untuk menstandarkan proses pembuatan simplisia dan ekstrak umbi bawang Dayak (Muthia et al, 2021). Selain itu pada kondisi pandemi COVID-19 ini, umbi bawang Dayak yang telah dilaporkan sebagai imunomodulator memiliki potensi untuk dikembangkan karena dapat membantu menjaga daya tahan tubuh (Febrinda et al, 2021).…”

The Antiproliferative Effect of Chloroform Fraction of Eleutherine bulbosa (Mill.) Urb. on 2D- and 3D-Human Lung Cancer Cells (A549) Model

“…The cytotoxic effects of E. bulbosa bulbs on lung cancer cells were initially screened using a 2D culture model; however, due to the inability to mimic the in vivo environment, the 3D cell culture model was used for a secondary screening due to its better capacity to simulate the in vivo environment and produce more accurate data on the cytotoxic effects of E. bulbosa on lung cancer cells [ 21 , 22 ]. This study focused on the bulbs rather than other parts of the plant because the bulbs, as reported in previous studies, contain a higher concentration of the bioactive components with strong cytotoxic potential against various cancer cells [ 17 , 23 ]. This study is the first to present the result of the antiproliferative effects of E. bulbosa bulbs on lung cancer cells using 2D and 3D culture models.…”