Eco-friendly technology for preparation, characterization and promotion of honey bee propolis extract loaded cellulose acetate nanofibers in medical domains

Sharaf, S.; El‐Naggar, Mehrez E.

doi:10.1007/s10570-018-1921-1

Cited by 64 publications

(28 citation statements)

References 25 publications

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“…The fiber diameter was increased from 539 ± 99 nm PHBH/30EP (1%) to 739 ± 197 nm PHBH/30EP (7%). A similar behavior was obtained from cellulose acetate nanofibers with a high concentration of honey bee propolis prepared by ethanol solution [33]. Kim et al [20] also reported that the propolis concentration increased the fiber diameter and provided the linking of PU fibers due to its adhesive properties and demonstrated the optimum utilization of the bonding element for reinforcement of nonwoven fabric.…”

Section: Morphology Of Phbh Composite Nanofibers With Natural Antibacsupporting

confidence: 59%

“…To examine the antibacterial activity of natural antibacterial reagents, S. aureus and E. coli were chosen as representatives for gram-positive and gram-negative bacteria. The test method was the disk diffusion test, which has been well established by previous reports [2,20,[30][31][32][33]. The bacterial culture was spread on the Luria Bertani (LB) agar surface by using a sterile cotton bat.…”

Section: Antibacterial Activity Testmentioning

confidence: 99%

“…The antibacterial activity of neat PHBH nanofibers, PHBH composite nanofibers with centella, propolis, and hinokitol against the gram-positive bacteria S. aureus and gram-negative bacteria E. coli was evaluated using inhibition zone method [20,33,40,41]. The antimicrobial effect of samples was evaluated at 37 • C (S. aureus) and 30 • C (E. coli) for 24 h. Table 4 presents the diameters of the inhibition zone for PHBH composite nanofibers with natural products.…”

Section: In Vitro Antibacterial Activitymentioning

confidence: 99%

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Natural Antibacterial Reagents (Centella, Propolis, and Hinokitiol) Loaded into Poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] Composite Nanofibers for Biomedical Applications

2019

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Centella asiatica, propolis, and hinokitiol, as natural antibacterial reagents, were integrated into the poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] (PHBH) polymer to produce antibacterial wound dressings, using electrospinning process. The results showed that the fiber diameters and surface morphology of PHBH composite nanofibers were influenced by the addition of ethanol–centella (EC), methanol–centella (MC), ethanol–propolis (EP), and ethanol–hinokitiol (EH) at various ratios compared to pristine PHBH nanofibers. From FT-IR, the nanofibrous samples with higher contents of natural antibacterial substances showed the peaks of carboxylic acid, aromatic ring, and tropolone carbon ring from centella, propolis, and hinokitiol, respectively. Furthermore, the tensile strength of neat PHBH nanofibers was increased from 8.00 ± 0.71 MPa up to 16.35 ± 1.78 MPa by loading of propolis (EP) 7% into PHBH. X-ray analysis explained that the loading of propolis (EP) was also able to increase the crystallinity in PHBH composite nanofibers from 47.0% to 54.5%. The antibacterial results demonstrated that PHBH composite nanofibers containing natural antibacterial products were potent inhibitors against the growth of Escherichia coli and Staphylococcus aureus, amongst them hinokitiol and propolis proved to be the most effective. Additionally, the release studies displayed that centella and hinokitiol had faster release from PHBH composite nanofibers in comparison to propolis.

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Section: Morphology Of Phbh Composite Nanofibers With Natural Antibacsupporting

confidence: 59%

Section: Antibacterial Activity Testmentioning

confidence: 99%

Section: In Vitro Antibacterial Activitymentioning

confidence: 99%

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Natural Antibacterial Reagents (Centella, Propolis, and Hinokitiol) Loaded into Poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] Composite Nanofibers for Biomedical Applications

2019

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“…2c). The reason why the morphology of the electrospun bers was changed is rooted in the fact that changing acetic acid concentration is associated with the rheological behavior of the CA solution as well as with the stretching of the electrospinning jet [45,46]. Subsequently, the prepared NFs with 90:10 v/v acetic acid/water was used for further work due to the lower diameter, proper morphology and uniform structure.…”

Section: The Optimum Condition For Electrospun Ber Mats Of Ca and Erymentioning

confidence: 99%

Antibacterial wound dressing nanofibrous mats composed of cellulose acetate loaded with chitosan/erythromycin nanoparticles

Doostan

Maleki

Doostan

et al. 2020

Preprint

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This study attempts to fabricate the antibacterial nanofibrous mats composed of cellulose acetate (CA) nanofibers loaded with erythromycin-chitosan nanoparticles (Ery-CS NPs) intended for infected wound dressing. The Ery-loaded CS NPs were prepared by ionic gelation process and then incorporated into the CA electrospun nanofibers (NFs). The characterization of the NPs and mats were investigated by using dynamic light scattering (DLS), scanning electron microscopy (SEM), Attenuated Total Reflection Fourier transform infrared (ATR-FTIR) to show the size distribution, morphology and surface chemistry along with other physiochemical properties including hydrophilicity property, porosity, and water absorption capacity. The antimicrobial activity and cell viability of fibroblast cells were also evaluated. The results indicated that Ery was loaded into CS NPs with high encapsulation efficiency (95%). The CA NFs (17%) incorporated with the Ery-CS NPs (12 wt%) displayed smooth homogenous morphology with 141.7 ± 91.7 nm average diameter. The relevant analyses revealed that the NPs incorporated in NFs and provided high water holding capacity with high porosity. Finally, Ery-CS NPs/CA mats were able to inhibit the growth of both Gram-positive and Gram-negative bacteria as well as showed no cytotoxic effect on the human dermal fibroblast cells. Overall, our findings concluded that the proposed system could be potentially applied as the proper antibacterial mats for infected wound dressing applications.

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“…4 It has been demonstrated that biodegradable polymers used to produce drug-loaded microparticles result in the drug being molecularly dispersed in amorphous form, thereby significantly improving the bioavailability of non-water-soluble drugs. 5 Over the past two decades, researchers have been exploring biodegradable nanomaterials for drug delivery [6][7][8][9][10][11][12][13][14][15] in which nanoparticles are frequently employed as oral, injectable or inhalable drug delivery systems whereby the drug is continuously released from the particles over a defined period of time. Drug-loaded nanoparticles fabricated with biodegradable polymers are promising candidates for oral delivery of poorly watersoluble drugs.…”

Section: Introductionmentioning

confidence: 99%

<p>Copolymer Composition and Nanoparticle Configuration Enhance in vitro Drug Release Behavior of Poorly Water-soluble Progesterone for Oral Formulations</p>

Zhang¹,

Zhang²,

Illangakoon³

et al. 2020

IJN

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Hypothesis: Developing oral formulations to enable effective release of poorly watersoluble drugs like progesterone is a major challenge in pharmaceutics. Coaxial electrospray can generate drug-loaded nanoparticles of strategic compositions and configurations to enhance physiological dissolution and bioavailability of poorly water-soluble drug progesterone. Experiments: Six formulations comprising nanoparticles encapsulating progesterone in different poly(lactide-co-glycolide) (PLGA) matrix configurations and compositions were fabricated and characterized in terms of morphology, molecular crystallinity, drug encapsulation efficiency and release behavior. Findings: A protocol of fabrication conditions to achieve 100% drug encapsulation efficiency in nanoparticles was developed. Scanning electron microscopy shows smooth and spherical morphology of 472.1±54.8 to 588.0±92.1 nm in diameter. Multiphoton Airyscan superresolution confocal microscopy revealed core-shell nanoparticle configuration. Fourier transform infrared spectroscopy confirmed presence of PLGA and progesterone in all formulations. Diffractometry indicated amorphous state of the encapsulated drug. UV-vis spectroscopy showed drug release increased with hydrophilic copolymer glycolide ratio while core-shell formulations with progesterone co-dissolved in PLGA core exhibited enhanced release over five hours at 79.9±1.4% and 70.7±3.5% for LA:GA 50:50 and 75:25 in comparison with pure progesterone without polymer matrix in the core at 67.0±1.7% and 57.5±2.8%, respectively. Computational modeling showed good agreement with the experimental drug release behavior in vitro.

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Eco-friendly technology for preparation, characterization and promotion of honey bee propolis extract loaded cellulose acetate nanofibers in medical domains

Cited by 64 publications

References 25 publications

Natural Antibacterial Reagents (Centella, Propolis, and Hinokitiol) Loaded into Poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] Composite Nanofibers for Biomedical Applications

Natural Antibacterial Reagents (Centella, Propolis, and Hinokitiol) Loaded into Poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] Composite Nanofibers for Biomedical Applications

Antibacterial wound dressing nanofibrous mats composed of cellulose acetate loaded with chitosan/erythromycin nanoparticles

<p>Copolymer Composition and Nanoparticle Configuration Enhance in vitro Drug Release Behavior of Poorly Water-soluble Progesterone for Oral Formulations</p>

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