&lt;p&gt;Copolymer Composition and Nanoparticle Configuration Enhance in vitro Drug Release Behavior of Poorly Water-soluble Progesterone for Oral Formulations&lt;/p&gt;

Zhang, Yue; Zhang, Rui; Illangakoon, Upulitha Eranka; Harker, A. H.; Thrasivoulou, Christopher; Parhizkar, Maryam; Edirisinghe, Mohan; Luo, C. J.

doi:10.2147/ijn.s257353

Cited by 14 publications

(4 citation statements)

References 43 publications

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“…However, FDA has approved the use of SLS up to 2% in dissolution media (30). Considering in vitro dissolution study, two stages could be determined according to the rate of drug release; phase I is defined as burst release and phase II shows sustained release (31). Owing to TAA released from the pores near the particle surface, burst release could have occurred within 2 hours in all formulations.…”

Section: Discussionmentioning

confidence: 99%

Development of Triamcinolone Acetonide Loaded Poly(lactide-co-glycolic acid) Dry Powder Inhaler Formulations For The Treatment of Asthma

Yurdasiper

2022

Clinical and Experimental Health Sciences

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Objective:The objective of this study was to develop triamcinolone acetonide (TAA) loaded poly(lactide-co-glycolic acid) (PLGA) dry powder inhaler (DPI) formulations by using spray dryer and to characterize the formulations with reference to their appropriateness for pulmonary drug delivery.Methods: PLGA dry powder inhalers containing TAA were produced in two stages. In the first step, PLGA microparticles were prepared by emulsion-solvent evaporation method and the DPI formulations were produced by the spray-drying process using mannitol and leucine. TAA loaded PLGA DPI was classified physicochemical properties. The in vitro dissolution test was carried out using modified USP apparatus 2. Aerosol performance was identified with next generation impactor.Results: This study has demonstrated that TAA loaded PLGA DPI were effectively prepared.Scanning electron microscope illustrates the spherical shape, particle size (D50) was established to be between 2.7-3.1 µm and all formulations charged negatively. Special chemical interaction in the DPI was not observed by FT-IR. The in vitro aerosol performance study represented DPI formulations have the proper aerodynamic properties for targeting the lungs.The in vitro TAA release from DPI formulations decreased with increasing of PLGA concentration. Conclusion:Developed PLGA dry powder inhaler formulations containing TAA have shown suitable aerodynamic characteristics to be administered to the lungs thereby could improve in the management of asthma by increasing TAA residency in the lungs for a prolonged period of time.

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Section: Discussionmentioning

confidence: 99%

Development of Triamcinolone Acetonide Loaded Poly(lactide-co-glycolic acid) Dry Powder Inhaler Formulations For The Treatment of Asthma

Yurdasiper

2022

Clinical and Experimental Health Sciences

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“…The morphology of the produced progesterone particles and their surface were characterized by scanning electron microscopy (FE‐SEM, Tescan/Mira, Brno, Czech Republic). In addition, the evaluation of the particle size and the differentiation of microparticles or nanoparticles was checked by FE‐SEM method (Zhang et al, 2020).…”

Section: Methodsmentioning

confidence: 99%

Development and evaluation of an injectable slow‐release progesterone formulation for estrus synchronization in ewes out of the breeding season

Salarpoor

Kadivar

Davoodian

et al. 2023

Reprod Domestic Animals

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Estrus synchronization is a valuable management method in enhancing reproductive efficiency in small ruminants. Sheep is a seasonally polyestrus animal with spontaneous estrus and ovulation during periods of short daylight (Bartlewski et al., 2011). Obviously, restricting reproduction to the breeding season decreases individual productivity and profitability, especially in single-bearing breeds.Using estrus induction protocols during non-breeding season can solve this problem and raise the number of lamb per individual to three every 2 years.Introducing a novel ram to anestrus ewes can trigger an ovulatory LH surge through a series of neuroendocrine events within the hypothalamus and pituitary gland (Martin et al., 1980). However,

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“…The pH and specific viscosity of all formulations were measured with a digital pH meter and U-tube viscometer as mentioned earlier. 47 , 48 …”

Section: Methodsmentioning

confidence: 99%

Physicochemical Characterization of Finasteride Nanosystem for Enhanced Topical Delivery

Irfan¹,

Shah²,

Khan³

et al. 2021

IJN

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Introduction The current work aimed to formulate a novel chitosan-based finasteride nanosystem (FNS-NS) for skin delivery to optimize the drug availability in skin for a longer time and enhance ex vivo performance of finasteride against androgenic alopecia. Methods Both undecorated and chitosan decorated FNS-NSs were synthesized by a high energy emulsification technique. All the prepared nanosystems were further subjected to physicochemical characterizations like pH, viscosity, encapsulation efficiency, surface morphology and in vitro drug release behavior. The influence of the nanosystem on the drug permeation and retention in rat skin was examined using Franz diffusion cell apparatus. Results The droplet size of developed nanosystems ranged from 41 to 864 nm with a low polydispersity index. The zeta potential of the nanosystems was between -10 mV and +56 mV. This chitosan decorated nanosystem exhibited controlled drug release, ie about 78–97% in 24 h. Among all the nanosystems, our chitosan decorated formulation (F5) had low drug permeation (16.35 µg/cm 2 ) and higher drug retention (10.81 µg/cm 2 ). Conclusion The abovementioned results demonstrate satisfactory in vitro drug release, skin retention profiles and ex vivo performance with chitosan decorated FNS-NS (F5). This optimized formulation could increase drug availability in skin and could become a promising carrier for topical delivery to treat androgenic alopecia.

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<p>Copolymer Composition and Nanoparticle Configuration Enhance in vitro Drug Release Behavior of Poorly Water-soluble Progesterone for Oral Formulations</p>

Cited by 14 publications

References 43 publications

Development of Triamcinolone Acetonide Loaded Poly(lactide-co-glycolic acid) Dry Powder Inhaler Formulations For The Treatment of Asthma

Development of Triamcinolone Acetonide Loaded Poly(lactide-co-glycolic acid) Dry Powder Inhaler Formulations For The Treatment of Asthma

Development and evaluation of an injectable slow‐release progesterone formulation for estrus synchronization in ewes out of the breeding season

Physicochemical Characterization of Finasteride Nanosystem for Enhanced Topical Delivery

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