Ebselen can Protect Male Reproductive Organs and Male Fertility from Manganese Toxicity: Structural and Bioanalytical Approach in a Rat Model

Mohammed, Amira; Ebraheim, Lamiaa L.M.; Metwally, Mohamed M.M.

doi:10.1016/j.biopha.2018.03.086

Cited by 16 publications

(6 citation statements)

References 51 publications

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“…Essential metals, such as manganese and selenium, can be harmful depending on their concentrations. Rats exposed to low manganese levels had increased testosterone levels, while high manganese levels resulted in decreased testosterone levels [25–27]. Exposing adult male rats to low selenium concentrations resulted in increased testosterone levels, while high levels resulted in decreased testosterone levels [28, 29].…”

Section: Introductionmentioning

confidence: 99%

Blood metal levels and serum testosterone concentrations in male and female children and adolescents: NHANES 2011–2012

Yao

Zhou

Xu³

et al. 2019

PLoS ONE

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Environmental exposure to metals is ubiquitous, but its relation to androgen hormone levels is not well understood, especially in children and adolescents. This study aimed to explore the relationship between blood metal concentrations (lead, cadmium, total mercury, selenium, and manganese) and serum total testosterone (TT) levels in 6–19-year-old children and adolescents in the National Health and Nutrition Examination Survey (NHANES) 2011–2012. Weighted multivariable linear regression models using NHANES sampling weights were employed to evaluate the association between log-transformed serum TT and each metal categories in male and female children (age 6-11years) and adolescents (age 12–19 years). We established that blood cadmium and manganese levels were associated with significantly higher serum TT levels in the female adolescents. Additionally, the blood selenium levels in male adolescents were related to significantly higher serum TT. No significant associations between blood lead or total mercury levels and TT were observed in children or adolescents of either sex. These findings suggest that environmental exposure to certain metals could affect serum TT levels in adolescents, which might have important implications for the health of adolescents. Further research is required to confirm and extend our present findings.

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Section: Introductionmentioning

confidence: 99%

Blood metal levels and serum testosterone concentrations in male and female children and adolescents: NHANES 2011–2012

Yao

Zhou

Xu³

et al. 2019

PLoS ONE

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“…Ebselen protects against manganese toxicity to male reproductive organs and male fertility was proven to be achieved by increasing the GSH activity (Ref. 84). The myocardial GSH level is preserved by oral ebselen in an ischaemia-reperfusion model (Ref.…”

Section: Targeting Thiol-containing Compoundsmentioning

confidence: 99%

Ebselen, a multi-target compound: its effects on biological processes and diseases

Cai

Xiang

et al. 2021

Expert Rev. Mol. Med.

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Ebselen is a well-known synthetic compound mimicking glutathione peroxidase (GPx), which catalyses some vital reactions that protect against oxidative damage. Based on a large number of in vivo and in vitro studies, various mechanisms have been proposed to explain its actions on multiple targets. It targets thiol-related compounds, including cysteine, glutathione, and thiol proteins (e.g., thioredoxin and thioredoxin reductase). Owing to this, ebselen is a unique multifunctional agent with important effects on inflammation, apoptosis, oxidative stress, cell differentiation, immune regulation and neurodegenerative disease, with anti-microbial, detoxifying and anti-tumour activity. This review summarises the current understanding of the multiple biological processes and molecules targeted by ebselen, and its pharmacological applications.

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“…Although an adequate intake of Mn 2+ is necessary for the human body, the excessive Mn 2+ exposure can lead to male fertility decline. Numerous studies proved that environmental toxicants, manganese (Mohammed et al, 2018 ; Wirth et al, 2007 ), cadmium (El‐Neweshy et al, 2013 ; Koriem et al, 2013 ) and mercury (Ernst & Lauritsen, 1991 ; Slivkova et al, 2010 ), have negative effects on spermatogenesis in rodents and humans. Further research has been reported that the major target site of environmental toxicants in testes was blood–testis barrier (BTB).…”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Protective effects of Coridius chinensis extracts on rat reproductive damage induced by manganese

et al. 2021

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Manganese (Mn 2+ ) is found in very small amounts in the body, but it plays an important role in maintaining normal physiological condition and involves in many cellular biological processes. It also involves the composition of many enzymes and affects the enzyme activity. It is also required for other aspects, such as blood glucose regulation, development of bone and reproduction, and brain (Aschner & Aschner, 2005;Greger, 1999). Although an adequate intake of Mn 2+ is necessary for the human body, the excessive Mn 2+ exposure can lead to male fertility decline. Numerous studies proved that environmental toxicants, manganese (Mohammed et al., 2018;

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Ebselen can Protect Male Reproductive Organs and Male Fertility from Manganese Toxicity: Structural and Bioanalytical Approach in a Rat Model

Cited by 16 publications

References 51 publications

Blood metal levels and serum testosterone concentrations in male and female children and adolescents: NHANES 2011–2012

Blood metal levels and serum testosterone concentrations in male and female children and adolescents: NHANES 2011–2012

Ebselen, a multi-target compound: its effects on biological processes and diseases

Protective effects of Coridius chinensis extracts on rat reproductive damage induced by manganese

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