Early onset oral tongue cancer in the United States: A literature review

Campbell, Benjamin R.; Netterville, James L.; Sinard, Robert J.; Mannion, Kyle; Rohde, Sarah L.; Langerman, Alexander; Kim, Young Jin; Lewis, James S.; Kuhs, Krystle A. Lang

doi:10.1016/j.oraloncology.2018.10.009

Cited by 34 publications

(41 citation statements)

References 41 publications

(106 reference statements)

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“…Our study failed to demonstrate LVI as an independent prognostic marker in young OSCC patients in multivariate analysis (HR = 2.532 95% C.I. 0.857-7.480; p-value = .093), LVI has been identified as a useful histological marker of aggressiveness in OSCC (Campbell et al, 2018). Although several reports suggested a higher presence of LVI in young OSCC patients, the prognostic role of this parameter is debated (Farquhar et al, 2018).…”

Section: Discussioncontrasting

confidence: 73%

Histological features and survival in young patients with HPV‐negative oral squamous cell carcinoma

et al. 2020

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Oral squamous cell carcinoma (OSCC) is the most common malignant tumour of the oral cavity, representing the eighth most common cancer worldwide (Shield et al., 2017). Although OSCC usually occurs in males between the age of 60 and 80 years, a rise in OSCC incidence among younger subjects has been reported in recent years (Jeon et al., 2017). In particular, the frequency of OSCC among young adults has increased since the 1980s and to date these patients are 4%-12% of all OSCC cases (Muller, Pan, Li,

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Section: Discussioncontrasting

confidence: 73%

Histological features and survival in young patients with HPV‐negative oral squamous cell carcinoma

et al. 2020

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“…Previous studies from this group have attempted to assess the prevalence of HPV infection among the adult and pediatric clinic populations [15][16][17]. These studies appeared to support evidence that has suggested the incidence of oral HPV infection in the United States may, in fact, be increasing [8,9,11]. However, other recent studies of microbial prevalence have recently increased the potential pool of oral samples available for further HPV screening and analysis [18,19].…”

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

“…In fact, HPV infection has been identified as a clinically significant biomarker and prognostic indicator for oral squamous cell carcinomas [9][10][11]. These studies suggest that oral infection with high-risk HPV may significantly increase the risk of developing oral cancers, as well as limiting the long-term prognosis for these patients [10,11]. Due to the long time horizon for HPVdriven oncogenesis and oral tumor development, a greater focus has been placed on early detection and prevention efforts [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Screening for Oral High-risk Human Papillomavirus (HPV) among a Pediatric Patient Population

Bowen¹,

Kingsley²

2019

JAMMR

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Introduction: Human papillomavirus (HPV) is a known cancer-causing virus that has been primarily linked to cervical cancers. Recent studies have shown that HPV may also induce cancer in other tissues, including oral epithelia and mucosa. To determine the presence of oral HPV infection among pediatric patients, salivary samples were assessed to determine oral prevalence of high-risk HPV. Methods: Using existing pediatric saliva samples from pediatric clinic patients (aged 6 -16 years), this retrospective study involved isolating DNA for PCR screening for both high-risk strains of HPV (HPV16, HPV18). A total of n=98 patient samples were available for analysis. Results: Demographic analysis of these samples revealed the majority were derived from females (63.2%) and mostly from Hispanics (54.1%). DNA was successfully isolated from 95.9% of samples (n=94/98) with an average concentration of 142.5 ng/uL. PCR screening demonstrated only a subset of patient samples harbored high-risk strains, HPV16 (n=9) and HPV18 (n=6), which Bowen and Kingsley; JAMMR, 29(9): 1-8, 2019; Article no.JAMMR.48883 2 represents 15.9% of the total sample population -and were concentrated among the older patients (>13 years old). Conclusions: Although this retrospective study does not have a sufficient sample size to provide more robust analysis of other risk factors (race, sex, sociodemographic), these results to demonstrate that oral HPV infection may be successfully detected among a pediatric population. As more studies demonstrate oral HPV infection in children, these data are of significant value to other dental, medical, oral and public health professionals who seek to further an understanding of oral health and disease risk in pediatric populations. Original Research Article

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“…2 A recent systematic review found that there is no evidence to support a role for HPV in early onset OTSCC, and patients with early onset OTSCC tend to have less history of tobacco use than typical onset patients. 8 Some researchers have postulated that early onset OTSCC is a unique and more aggressive biological entity compared to typical onset oral cavity cancer, which has traditionally linked with tobacco use. [9][10][11][12] This hypothesis has raised questions about whether patients with early onset OTSCC also have higher rates of recurrence.…”

Section: Introductionmentioning

confidence: 99%

Age and risk of recurrence in oral tongue squamous cell carcinoma: Systematic review

et al. 2020

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The incidence of oral tongue squamous cell carcinoma has been increasing in young patients (≤45 years) without a clear etiologic driver. It is unknown if younger patients have an increased risk of recurrence compared to older patients. A literature search was conducted through January 2020 using PubMed/MEDLINE, Embase, Cochrane, Scopus, Science Direct, and clinicaltrials.gov. This review was registered with PROSPERO (ID: CRD42020167498) and the PRISMA statement was followed. Studies were eligible for inclusion if they assessed risk of recurrence by age using a timeto-event analysis, used an age cutoff of ≤45 years or less for the younger cohort, and limited the analysis to the oral tongue subsite. Data were extracted independently by two reviewers using a form with a prespecified list of variables. There were 13 articles that met criteria for the qualitative synthesis (n = 1763 patients). The reported 5-year rates of disease-free survival ranged from 30% to 72% for the younger cohorts and 42% to 81% for the older cohorts. Three studies reported a statistically significant increased risk of recurrence in younger patients, three studies reported a nonsignificant increased risk in younger patients, and seven studies reported a similar risk in younger patients based on the time-to-event analyses. There may be an increased risk of recurrence for younger patients with oral tongue cancer. A definitive conclusion is precluded by limitations among individual studies, and additional research is warranted to examine this question.

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Early onset oral tongue cancer in the United States: A literature review

Cited by 34 publications

References 41 publications

Histological features and survival in young patients with HPV‐negative oral squamous cell carcinoma

Histological features and survival in young patients with HPV‐negative oral squamous cell carcinoma

Screening for Oral High-risk Human Papillomavirus (HPV) among a Pediatric Patient Population

Age and risk of recurrence in oral tongue squamous cell carcinoma: Systematic review

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