Dual stimuli-responsive Fe3O4 graft poly(acrylic acid)-block-poly(2-methacryloyloxyethyl ferrocenecarboxylate) copolymer micromicelles: surface RAFT synthesis, self-assembly and drug release applications

Wang, Yuan; Zhang, Xueyin; Luo, Yan‐Ling; Xu, Feng; Su, Yuyu

doi:10.1186/s12951-017-0309-y

Cited by 13 publications

(23 citation statements)

References 53 publications

(72 reference statements)

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“…43a The additional peak at 1593 cm –1 in FTIR spectra of pristine Fe 3 O 4 nanoparticles (Fe 3 O 4 (OH) x 45 ) corresponds to the −OH bending modes, as present at the surface of Fe 3 O 4 nanoparticles. 46 …”

Section: Results and Discussionmentioning

confidence: 99%

“…The magnetic property of the material signifies its various potential applications such as in magnetic resonance imaging (MRI), 49b drug delivery, 49c magnetically targeted therapy of tumor, 46 and magnetic separation, 49a in addition to its applications as an NMR contrast agent. 51 …”

Section: Results and Discussionmentioning

confidence: 99%

“…These above-mentioned aspects render the PAAVSA/Fe 3 O 4 system versatile for potential applications in targeted and controlled drug delivery, 49c magnetically targeted therapy, 46 bioseparation, 57c pH sensors. 64 It has also immense potential to be used as biosensors in disease diagnosis, such as gastroesophageal reflux disease (GERD), where pH of esophagus in normal conditions is close to 7, whereas it goes down to 4 or below intermittently in a diseased condition, due to gastroesophageal reflux.…”

Section: Results and Discussionmentioning

confidence: 99%

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Target-Specific Superparamagnetic Hydrogel with Excellent pH Sensitivity and Reversibility: A Promising Platform for Biomedical Applications

2020

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Superparamagnetism has been widely used for many biomedical applications, such as early detection of inflammatory cancer and diabetes, magnetic resonance imaging (MRI), hyperthermia, etc., whereas incorporation of superparamagnetism in stimulus-responsive hydrogels has now gained substantial interest and attention for application in these fields. Recently, pH-responsive superparamagnetic hydrogels showing the potential use in disease diagnosis, biosensors, polymeric drug carriers, and implantable devices, have been developed based on the fact that pH is an important environmental factor in the body and some disease states manifest themselves by a change in the pH value. However, improvement in pH sensitivity of magnetic hydrogels is a dire need for their practical applications. In this study, we report the distinctly high pH sensitivity of new synthesized dual-responsive magnetic hydrogel nanocomposites, which was accomplished by copolymerization (free-radical polymerization) of two pH-sensitive monomers, acrylic acid (AA) and vinylsulfonic acid (VSA) with an optimum ratio, in the presence of presynthesized superparamagnetic iron oxide nanoparticles (Fe 3 O 4 (OH) x ). The monomers contain pH-sensitive functional groups (COO – and SO 3 – for AA and VSA, respectively), and they have also been widely used as biomaterials because of the good biocompatibility. The pH sensitivity of the superparamagnetic hydrogel, poly(acrylic acid- co -vinylsulfonic acid), PAAVSA/Fe 3 O 4 , was investigated by swelling studies at different pH values from pH 7 to 1.4. Distinct pH reversibility of the system was also demonstrated through swelling/deswelling analysis. Thermal stability, chemical configuration, magnetic response, and structural properties of the system have been explored by suitable characterization techniques. Furthermore, the study reveals a pH-responsive significant change in the overall morphology and packing fraction of iron oxide nanoparticles in PAAVSA/Fe 3 O 4 via energy-dispersive X-ray (EDX) elemental mapping with the field emission scanning electron microscopy (FESEM) study (for freeze-dried PAAVSA/Fe 3 O 4 , swelled at different pH values), implying a drastic change in susceptibility and induced saturation magnetization of the system. These important features could be easily utilized for the purpose of diagnosis using magnetic probe and/or impedance analysis techniques.

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Section: Results and Discussionmentioning

confidence: 99%

Section: Results and Discussionmentioning

confidence: 99%

Section: Results and Discussionmentioning

confidence: 99%

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Target-Specific Superparamagnetic Hydrogel with Excellent pH Sensitivity and Reversibility: A Promising Platform for Biomedical Applications

2020

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“…Hybrid block copolymers based PAA, poly(2-methacryloyloxyethyl ferrocenecarboxylate), and Fe 3 O 4 with dual stimuli responsiveness were developed using a two-step sequential reversible addition-fragmentation chain transfer polymerization process. It was non-toxic, stable, and entrapped hydrophobic anticancer drugs, which were then delivered quickly in particular microenvironments, including acidic pH and high reactive oxygen species [ 219 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

et al. 2022

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Polyacrylic acid (PAA) is a non-toxic, biocompatible, and biodegradable polymer that gained lots of interest in recent years. PAA nano-derivatives can be obtained by chemical modification of carboxyl groups with superior chemical properties in comparison to unmodified PAA. For example, nano-particles produced from PAA derivatives can be used to deliver drugs due to their stability and biocompatibility. PAA and its nanoconjugates could also be regarded as stimuli-responsive platforms that make them ideal for drug delivery and antimicrobial applications. These properties make PAA a good candidate for conventional and novel drug carrier systems. Here, we started with synthesis approaches, structure characteristics, and other architectures of PAA nanoplatforms. Then, different conjugations of PAA/nanostructures and their potential in various fields of nanomedicine such as antimicrobial, anticancer, imaging, biosensor, and tissue engineering were discussed. Finally, biocompatibility and challenges of PAA nanoplatforms were highlighted. This review will provide fundamental knowledge and current information connected to the PAA nanoplatforms and their applications in biological fields for a broad audience of researchers, engineers, and newcomers. In this light, PAA nanoplatforms could have great potential for the research and development of new nano vaccines and nano drugs in the future.

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“…Among these stimuli, redox as a stimulus is especially appealing because of the great difference in the concentration of GSH between the interior (10 mM) and exterior (ca. 10 μM) of tumors [35, 36]. Furthermore, tumor tissues are highly hypoxic, with at least fourfold more GSH than normal tissues [37, 38].…”

Section: Introductionmentioning

confidence: 99%

Redox/NIR dual-responsive MoS2 for synergetic chemo-photothermal therapy of cancer

Liu

Zheng

et al. 2019

J Nanobiotechnol

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Background The construction of a multifunctional drug delivery system with a variety of advantageous features, including targeted delivery, controlled release and combined therapy, is highly attractive but remains a challenge. Results In this study, we developed a MoS 2 -based hyaluronic acid (HA)-functionalized nanoplatform capable of achieving targeted delivery of camptothecin (CPT) and dual-stimuli-responsive drug release. HA was connected to MoS 2 via a disulfide linkage, forming a sheddable HA shell on the surface of MoS 2 . This unique design not only effectively prevented the encapsulated CPT from randomly leaking during blood circulation but also significantly accelerated the drug release in response to tumor-associated glutathione (GSH). Moreover, the MoS 2 -based generated heat upon near-infrared (NIR) irradiation could further increase the drug release rate as well as induce photothermal ablation of cancer cells. The results of in vitro and in vivo experiments revealed that MoS 2 –SS–HA–CPT effectively suppressed cell proliferation and inhibited tumor growth in lung cancer cell-bearing mice under NIR irradiation via synergetic chemo-photothermal therapy. Conclusions The as-prepared MoS 2 –SS–HA–CPT with high targeting ability, dual-stimuli-responsive drug release, and synergistic chemo-photothermal therapy may provide a new strategy for cancer therapy. Electronic supplementary material The online version of this article (10.1186/s12951-019-0510-2) contains supplementary material, which is available to authorized users.

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Dual stimuli-responsive Fe3O4 graft poly(acrylic acid)-block-poly(2-methacryloyloxyethyl ferrocenecarboxylate) copolymer micromicelles: surface RAFT synthesis, self-assembly and drug release applications

Cited by 13 publications

References 53 publications

Target-Specific Superparamagnetic Hydrogel with Excellent pH Sensitivity and Reversibility: A Promising Platform for Biomedical Applications

Target-Specific Superparamagnetic Hydrogel with Excellent pH Sensitivity and Reversibility: A Promising Platform for Biomedical Applications

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

Redox/NIR dual-responsive MoS2 for synergetic chemo-photothermal therapy of cancer

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