Redox/NIR dual-responsive MoS2 for synergetic chemo-photothermal therapy of cancer

Abstract

Background The construction of a multifunctional drug delivery system with a variety of advantageous features, including targeted delivery, controlled release and combined therapy, is highly attractive but remains a challenge. Results In this study, we developed a MoS 2 -based hyaluronic acid (HA)-functionalized nanoplatform capable of achieving targeted delivery of camptothecin (CPT) and dual-stimuli-responsive drug release. HA was connected to MoS 2 via a disulfide linkage, forming a sheddable HA shell on the surface of MoS 2 . This unique design not only effectively prevented the encapsulated CPT from randomly leaking during blood circulation but also significantly accelerated the drug release in response to tumor-associated glutathione (GSH). Moreover, the MoS 2 -based generated heat upon near-infrared (NIR) irradiation could further increase the drug release rate as well as induce photothermal ablation of cancer cells. The results of in vitro and in vivo experiments revealed that MoS 2 –SS–HA–CPT effectively suppressed cell proliferation and inhibited tumor growth in lung cancer cell-bearing mice under NIR irradiation via synergetic chemo-photothermal therapy. Conclusions The as-prepared MoS 2 –SS–HA–CPT with high targeting ability, dual-stimuli-responsive drug release, and synergistic chemo-photothermal therapy may provide a new strategy for cancer therapy. Electronic supplementary material The online version of this article (10.1186/s12951-019-0510-2) contains supplementary material, which is available to authorized users.

<p>Immunostimulatory Potential of MoS₂ Nanosheets: Enhancing Dendritic Cell Maturation, Migration and T Cell Elicitation</p>

“…The high near infrared ray absorbance, extraordinary electrocatalytic activity, easy surface modification and low biological toxicity make MSNs one of the most promising graphene analogues with wide applications in various fields, especially in nanobiomedicine. 2 To date, MSNs have been developed for use as bio-imaging probes, 3 biosensors, [4][5][6] photothermal therapy agents, [7][8][9] drug carriers [10][11][12] and tissue engineering scaffolds, 13 among other uses. The possibility of using MSNs as immuneregulatory adjuvants to manipulate the immune responses is also a very fascinating and a meaningful research topic.…”

Stimuli-Responsive Drug Delivery Systems for the Diagnosis and Therapy of Lung Cancer

“…Light-triggered drug release can also be combined with other stimuli, including internal stimuli (e.g., pH [ 38 , 39 , 40 ], enzyme [ 41 ], glutathione [ 42 , 43 ], and other external stimuli (e.g., radio frequency [ 44 ]), for enhanced targeted therapy to lung cancer. For example, as the tumor microenvironment is enriched in esterase, introducing the esterase-labile ester bond to the therapeutic system can achieve tumor microenvironment-responsive drug release in situ.…”

Recent advance in near-infrared/ultrasound-sensitive 2D-nanomaterials for cancer therapeutics

“…In addition, the integration of MoS 2 -based nano-platform with other treatment techniques (e.g., PTT and chemotherapy) can drastically enhance the efficacy of cancer therapy. Recently, Liu et al [244] developed a MoS 2 -based tumor-targeting nanoplatform for synergistic chemotherapy/PTT (Fig. 5).…”