Dual effects of fluoxetine on mouse early embryonic development

Kim, Chang-Woon; Choe, Changyong; Kim, Eun Jin; Lee, Jae Ik; Yoon, Sang-Wook; Cho, Young-Woo; Han, Sunkyu; Tak, Hyun-Min; Han, Jaehee; Kang, Dawon

doi:10.1016/j.taap.2012.09.020

Cited by 14 publications

(25 citation statements)

References 57 publications

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“…The clearance of fluoxetine decreases in the postpartum period and fluoxetine serum in the mother is higher in this period than in the third trimester of pregnancy 18 , which could explain the fibroblast, cementoblast and osteoblast reduction in the periodontal ligament in only the FGL group.…”

Section: Discussionmentioning

confidence: 96%

Fluoxetine effects on periodontogenesis: histomorphometrical and immunohistochemical analyses in rats

et al. 2017

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Reports have indicated that serotonin plays an important role in cell migration and differentiation during the organogenesis of several tissues, including the oral types. Administration of selective serotonin reuptake inhibitor (SSRI) drugs during pregnancy could affect the delivery of serotonin to embryonic tissues altering its development. Objective This study aimed to assess the effects of fluoxetine, a selective serotonin reuptake inhibitor, on the formation of the periodontal ligament during pregnancy and lactation in rat pups.Material and Methods Twelve pregnant rats of Wistar lineage were divided into four study groups. In the control group, 0.9% sodium chloride solution was administered orally, throughout the entire period of the 21 days of pregnancy (CG group) and in the CGL group, it was administrated during pregnancy and lactation (from day 1 of pregnancy to the 21st day after birth). Fluoxetine was administered orally at the dose of 20 mg/kg in a group treated during pregnancy only (FG group), and during pregnancy and lactation (FGL group). Histometrical, histochemical and immunohistochemical analysis of the maxillary first molar periodontium region of the 24 rat pups was made under light microscopy, and periodontal ligament collagen was qualitatively evaluated under a polarizing light microscope.Results The quantity of fibroblasts (p=0.006), osteoblasts (p=0.027) and cementoblasts (p=0.001) was reduced in pups from the rats that received fluoxetine during pregnancy and lactation. No alterations were seen in the collagen fibers.Conclusion These findings suggest that periodontal tissue may be sensitive to fluoxetine, and its interference in reducing periodontal cells depends on exposure time during lactation.

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Section: Discussionmentioning

confidence: 96%

Fluoxetine effects on periodontogenesis: histomorphometrical and immunohistochemical analyses in rats

et al. 2017

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“…Serotonin can be found in the embryonic brain as early as the fifth week of gestation and is involved in neurogenesis, neuronal differentiation, and synaptogenesis . Antidepressants are known to cross the placenta and the fetal blood brain barrier, reduce whole blood 5‐HT concentrations in the umbilical vein, and influence fetal brain development in rodents . The role of maternal antidepressant use on epilepsy in offspring needs to be further explored.…”

Section: Discussionmentioning

confidence: 99%

“…Exposure in utero to selective serotonin reuptake inhibitors (SSRIs) and other antidepressants has been associated with birth defects, prematurity, small for gestational age, low birth weight, poor neonatal adaptation syndrome, gestational hypertension, and preeclampsia, although not all studies support these findings . Antidepressant medication during pregnancy may affect early brain development in humans as it has been seen in animals . Disturbances in fetal brain development by antidepressant use in pregnancy could lead to an increased susceptibility to autism and attention deficit disorders in children .…”

Section: Introductionmentioning

confidence: 99%

“…[12][13][14][15] Antidepressant medication during pregnancy may affect early brain development in humans 16,17 as it has been seen in animals. [18][19][20] Disturbances in fetal brain development by antidepressant use in pregnancy could lead to an increased susceptibility to autism and attention deficit disorders in children. [21][22][23] Epilepsy is one of the most common neurological disorders in childhood, often with an unknown etiology, 24,25 but prenatal factors including eclampsia, major congenital anomalies, preterm delivery, small for gestational age, and low birth weight have been associated with an increased risk of childhood epilepsy.…”

Section: Introductionmentioning

confidence: 99%

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Prenatal exposure to antidepressants and risk of epilepsy in childhood

Mao

Pedersen

Christensen

et al. 2016

Pharmacoepidemiology and Drug

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“…Exposure to fluoxetine for 24 h showed a reduction in blastocyst formation, suggesting a time dependent effect of fluoxetine on blastocyst formation. It also appears that these effects are, in part, due to altered TREK signaling (Kim et al, 2012). In humans, the cardiomyocyte proliferation is essentially complete at birth, whereas in rodents cardiomyocyte growth and proliferation is robust for the first 14 days after birth (Clubb and Bishop, 1984; Walsh et al, 2010).…”

Section: Selective Serotonin Reuptake Inhibitorsmentioning

confidence: 99%

The effects of maternal depression and maternal selective serotonin reuptake inhibitor exposure on offspring

Olivier¹,

Åkerud²,

Kaihola³

et al. 2013

Front. Cell. Neurosci.

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It has been estimated that 20% of pregnant women suffer from depression and it is well-documented that maternal depression can have long-lasting effects on the child. Currently, common treatment for maternal depression has been the selective serotonin reuptake inhibitor medications (SSRIs) which are used by 2–3% of pregnant women in the Nordic countries and by up to 10% of pregnant women in the United States. Antidepressants cross the placenta and are transferred to the fetus, thus, the question arises as to whether children of women taking antidepressants are at risk for altered neurodevelopmental outcomes and, if so, whether the risks are due to SSRI medication exposure or to the underlying maternal depression. This review considers the effects of maternal depression and SSRI exposure on offspring development in both clinical and preclinical populations. As it is impossible in humans to study the effects of SSRIs without taking into account the possible underlying effects of maternal depression (healthy pregnant women do not take SSRIs), animal models are of great value. For example, rodents can be used to determine the effects of maternal depression and/or perinatal SSRI exposure on offspring outcomes. Unraveling the joint (or separate) effects of maternal depression and SSRI exposure will provide more insights into the risks or benefits of SSRI exposure during gestation and will help women make informed decisions about using SSRIs during pregnancy.

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Dual effects of fluoxetine on mouse early embryonic development

Cited by 14 publications

References 57 publications

Fluoxetine effects on periodontogenesis: histomorphometrical and immunohistochemical analyses in rats

Fluoxetine effects on periodontogenesis: histomorphometrical and immunohistochemical analyses in rats

Prenatal exposure to antidepressants and risk of epilepsy in childhood

The effects of maternal depression and maternal selective serotonin reuptake inhibitor exposure on offspring

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