Prenatal exposure to antidepressants and risk of epilepsy in childhood

Mao, Yanyan; Pedersen, Lars Henning; Christensen, Jakob; Vestergaard, Mogens; Zhou, Weijin; Olsen, Jørn; Sun, Yuelian

doi:10.1002/pds.4072

Cited by 15 publications

(25 citation statements)

References 61 publications

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“…as the main reason of the hospital contact. Approach 1 5 , 10 and approach 2 6 , 11 has been used in several papers conducted by authors of this study. In Figure 1 we used mock data for nine persons to illustrate the categorization of diagnoses (a primary or secondary diagnosis, a referral diagnosis, and an associated diagnosis), groups of persons according to their diagnoses (group 1, 2, and 3), detailed procedures of identifying patients of interest by approach 1 and 2, and persons identified by approach 1 and 2.…”

Section: Methodsmentioning

confidence: 99%

Importance of Reporting Complete Procedures of Identifying Patients from the Danish National Patient Registry: The Case of Neonatal Jaundice and Epilepsy

Sun¹,

Dreier²,

Wu³

et al. 2022

CLEP

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Objective The Danish National Patient Registry (DNPR) is a valuable resource for medical and epidemiological Research. However, not all research articles fully described procedures they used to identify events. In this study, we compared two approaches in identifying persons with a disease diagnosis using neonatal jaundice and epilepsy as examples. Methods A cohort of singletons born alive between the 1st January 1997 and the 30th November 2016 in Denmark was used for this purpose. Diagnostic information for a hospital contact in the registry included a primary diagnosis, secondary diagnoses, referral diagnoses, and additional information to a diagnosis (associated diagnoses), if any. Approach 1 identified patients of interest by considering all diagnostic information with exclusion of referral diagnoses only. Approach 2 identified patients of interest by additionally excluding diagnoses from a hospital contact that were coded with Z00 – Z99 of ICD-10 (for health service on examination and reproduction, etc.) as the main reason of the hospital contact. We presented the proportion of people with a diagnosis of neonatal jaundice and epilepsy by the two approaches and explored the potential explanations for the difference. Results For the example of neonatal jaundice, the study population included N=1,186,683 persons. The proportion of children with a diagnosis of neonatal jaundice was 5.5% (n=66,736) by approach 1 and 3.9% (n=45,928) by approach 2. For the example of epilepsy, the study population included N=1,183,273 persons. The proportion of children with a diagnosis of epilepsy were 1.2% (n=14,604) by approach 1 and 0.9% (n=10,441) by approach 2. Discussion This study demonstrated that the two approaches identified different proportion of persons with a diagnosis of neonatal jaundice and epilepsy. We advocated researchers report complete procedures of identifying patients for making research findings reproducible and comparable.

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Section: Methodsmentioning

confidence: 99%

Importance of Reporting Complete Procedures of Identifying Patients from the Danish National Patient Registry: The Case of Neonatal Jaundice and Epilepsy

Sun¹,

Dreier²,

Wu³

et al. 2022

CLEP

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“…The occurrence of disorders of the autism spectrum in particular is subject to special attention. The child may then have withdrawal symptoms (symptômes de sevrage) which vary depending on the drug [23][24][25]. Recently, a Danish team examined the link between taking an antidepressant during pregnancy and the occurrence of epilepsy in children.…”

Section: Mental Health Disorders Depression and Womenmentioning

confidence: 99%

“…Taking an antidepressant only in the months before pregnancy but not during pregnancy also increased the risk of epilepsy in children. In utero exposure to antidepressants and seems associated with an increased risk of epilepsy in children [24].…”

Section: Mental Health Disorders Depression and Womenmentioning

confidence: 99%

Therapy mental and psychological troubles (MPSYT) by repeating phrases of positive thoughts (TRPPT) with women. Intercultural comparison: Middle East and Europe, war and peace. A controlled and randomized study-Cognitive therapy & positive psychotherapy.

Alsaleh¹

2016

psychology-cognition

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Background: Positive education can be one of the tools that enable the women in different aspects of her life, which produces strong and healthy women, healthy family, and so healthy society. Mental and psychological troubles are common symptoms among women. The prevalence of mental and psychological troubles among women subjected to mental and psychological troubles is the highest in psycho-difficulties. The treatment of these mental and psychological troubles is recommended among women. Aim: The objective of this study was the first to evaluate the short-term effects of the method of Therapy by Repeating Phrases of Positive Thoughts in the war and peace. Method: The Syrian sample consisted of 20 women from the University of Damascus, aged 19 to 27 years, and 4 women with Multiple Sclerosis from Damascus Hospital and Ibn Alnafees Hospital, aged 20 to 29 years. The French sample consisted of 33 women from the University of Caen Normandy, aged 18 to 23 years. Results: Experimental group who benefited from treatment have lower level of depression, anxiety and stress and there were significant differences between experimental (p<0.05) and control groups (p>0.05). For Syrian samples, according to value of effect size (Cohen's d>0.80) and standardized response mean>0.80, negative automatic thought, depression, anxiety, stress decrease after Therapy by Repeating Phrases of Positive Thoughts; and positive automatic thought, self-esteem and satisfaction in life improve among multiple sclerosis women patients and students after Therapy by Repeating Phrases of Positive Thoughts. For French sample, according to value of effect size (Cohen's d which vary between 0.11-0.41) and standardized response mean which vary between 0.33-0.82, depression, anxiety, stress decrease after Therapy by Repeating Phrases of Positive Thoughts. The results showed a significant improvement in psychological disturbances throughout the experimental group and a significant reduction in stress following the Therapy by Repeating Phrases of Positive Thoughts protocol, less anxiety and also less depression. The short-term effect Therapy by Repeating Phrases of Positive Thoughts is significant. Treatment and remission of mental and psychological troubles are implemented by Therapy by Repeating Phrases of Positive Thoughts. The Therapy by Repeating Phrases of Positive Thoughts improves the mental health of women. Conclusion:The RPPT treat of depression, anxiety and stress among women subjected to MPSYT and war and improve their psychological well-being and quality of life. The Therapy by Repeating Phrases of Positive Thoughts are proposed here as a fast treatment against mental and psychological troubles. The results show improved stress control capabilities, improved mood and anxiety. Therapy by Repeating Phrases of Positive Thoughts has proved beneficial for women subjected to war and mental and psychological troubles. More subjects repeat phrases with a very positive sense, more depression, anxiety and stress decrease. Unlike medicinal treatments, the...

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“…On average, males have a marginally higher incidence of epilepsy than females while generalized epilepsies are more common among females and epilepsy with focal seizure are more common among males [ 5 ]. Epilepsy has a high degree of heritability indicating shared genetic components in epileptogenesis [ 6 – 8 ], but intrauterine factors like maternal preeclampsia [ 9 ], infections [ 10 ], and medication use in pregnancy [ 11 ] have also been associated with risk of epilepsy. Whether prenatal exposure to subtle differences in sex hormones plays a role in the development of epilepsy remains uncertain [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Risk of epilepsy in opposite-sex and same-sex twins: a twin cohort study

et al. 2018

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BackgroundThere is a complex interaction between female and male sex hormones and the risk of epilepsy. Whether prenatal exposure to higher levels of sex hormones affects the development of epilepsy in childhood or later in life is not well known. The sex hormone environment of fetuses may be affected by the sex of the co-twin. We estimated the risk of epilepsy for twins with an opposite-sex (OS) co-twin compared with twins with a same-sex (SS) co-twin.MethodsFrom the Danish Twin Registry, we identified OS female twins (n = 11,078), SS female twins (n = 19,186), OS male twins (n = 11,080), and SS male twins (n = 20,207) born between 1977 and 2009. The SS twins include monozygotic twins, dizygotic twins, and twins with unknown zygosity. These children were followed up from day 29 after birth until diagnosis of epilepsy, death, emigration, or end of follow-up (31 December 2011) whichever came first. Information on diagnosis of epilepsy was obtained from the Danish National Patient Registry. We calculated hazard ratios (HRs) and 95% confidence intervals (CIs) for epilepsy in the OS twins using a Cox proportional hazards regression model compared with the SS twins. To account for the correlation of twins from the same mother when estimating standard errors, we used the cluster option in Stata.ResultsWe identified 152 OS female twins, 282 SS female twins, 162 OS male twins, and 335 SS male twins diagnosed with epilepsy corresponding to an incidence rate of 9.9 and 9.7 per 10,000 person years for the OS and SS female twins, and 10.6 and 10.9 per 10,000 person years for the OS and SS male twins, respectively. We found a similar risk of epilepsy among the OS and SS female twins [HR = 1.01; 95% CI 0.83–1.24] as well as among the OS and SS male twins [HR = 0.94; 95% CI 0.78–1.14]ConclusionsIn this population-based study of Danish twins, we did not find difference in the risk of epilepsy between twins with an OS co-twin and twins with a SS co-twin. This applied to both female and male twins. The study therefore does not support the hypothesis that subtle hormone difference in fetal life due to co-twin may play a role in the development of epilepsy later in life.

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Prenatal exposure to antidepressants and risk of epilepsy in childhood

Abstract: Antidepressant use during pregnancy was associated with a higher risk of epilepsy among children whose mothers had also a registry-based hospital diagnosis of depression during pregnancy. Copyright © 2016 John Wiley & Sons, Ltd.

Cited by 15 publications

References 61 publications

Importance of Reporting Complete Procedures of Identifying Patients from the Danish National Patient Registry: The Case of Neonatal Jaundice and Epilepsy

Importance of Reporting Complete Procedures of Identifying Patients from the Danish National Patient Registry: The Case of Neonatal Jaundice and Epilepsy

Therapy mental and psychological troubles (MPSYT) by repeating phrases of positive thoughts (TRPPT) with women. Intercultural comparison: Middle East and Europe, war and peace. A controlled and randomized study-Cognitive therapy & positive psychotherapy.

Risk of epilepsy in opposite-sex and same-sex twins: a twin cohort study

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