Dose-Dependent Effect of Coriander (Coriandrum Sativum L.) and Fennel (Foeniculum Vulgare M.) on Lead Nephrotoxicity in Rats

doi:10.20431/2349-0365.0406006

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…These findings suggest possible nephroprotective property of the study herb. Our results are in line with a study of El-Masry which demonstrated nephroprotective effect of Foeniculum vulgare against lead induced neprotoxicity [35]. Similar renal protection was noted in another study using gentamicin as nephrotoxin and Foeniculum vulgare as protective agent [36].…”

Section: Discussionsupporting

confidence: 92%

Impact of Foeniculum vulgare Fortified Diet on Coagulation Profile and Some Biochemical Parameters

Abbas

Ikram

Hasan

et al. 2020

JPRI

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Aims: Coagulation profile shows the clotting ability of blood. Biochemical tests indicate health status of vital organs such as liver, heart and kidneys. Herbal products are being assessed for their role in affecting these parameters. We evaluated role of Foeniculum vulgare incorporated diet on coagulation profile and some important biochemical parameters. Study Design: Laboratory centred randomized controlled trial. Place and Duration of Study: Pharmacology Department of University of Karachi, Karachi between June 2018 and September 2018. Methodology: After selecting 30 healthy rabbits of either sex, we placed them in three groups; Control, 2% Foeniculum vulgare and 4% Foeniculum vulgare group. Control group was given standard diet whereas; 2% and 4% Foeniculum vulgare groups were maintained on standard diet containing 2% and 4% Foeniculum vulgare crushed seeds. Coagulation profile and some biochemical parameters were done after interval of a month, for two months. Results: Platelet count and fibrinogen increased while activated partial thromboplastin time (APTT) levels decreased in both the study groups animals as compared to control, while blood urea nitrogen (BUN), creatinine phosphokinase (CPK) and lactate dehydrogenase (LDH) elevation was noted both Foeniculum vulgare groups but within normal range. Conclusion: Foeniculum vulgare may have some role in affecting coagulation and biochemical profile These parameters, however, need clinical trial to validate reliability.

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Section: Discussionsupporting

confidence: 92%

Impact of Foeniculum vulgare Fortified Diet on Coagulation Profile and Some Biochemical Parameters

Abbas

Ikram

Hasan

et al. 2020

JPRI

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Potential nephroprotective phytochemicals: Mechanism and future prospects

Basist

Parveen

Zahiruddin

et al. 2022

Journal of Ethnopharmacology

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Hepatotoxicity and mitochondrial dysfunction after lead (Pb) exposure and the protective effect of fennel essential oil of this toxicity in Wister rats

Lemita

Djabri

Gasmi

et al. 2021

Acta Scientifica Naturalis

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The present work focuses on evaluation of the toxic effects of an exposure to lead (Pb) on the liver mitochondria function in Wistar rats and the protective role of the fennel essential oils (FEO). The experiments were conducted on Wistar rats, which were treated daily through orally gavages during 21 days. 24 animals were divided into four groups of 6 rats each one: the control group received water, while group II received FEO (0.5 mg/kg); group III received Pb (25 mg/kg), and group IV received Pb + FEO in the doses of (0,5 + 25 mg/kg). The mitochondrial dysfunction induced by lead is expressed by reducing mitochondrial respiration (O2 consumption) associated with an increase in mitochondrial swelling and permeability compared to the control group. A disturbance in the rates of oxidative stress biomarkers was also observed. This disturbance was expressed by an increase of the MDA rate and the Cytochromes C activity associated with depletion in the GSH rate and GPx activity compared to the control group. The rat’s co-treatment with FEO restored all these parameters to values similar to the Control. The whole of these results shows well that the exposure to the lead causes disturbances on the level mitochondrion, which are attenuated by fennel essential oils.

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Dose-Dependent Effect of Coriander (Coriandrum Sativum L.) and Fennel (Foeniculum Vulgare M.) on Lead Nephrotoxicity in Rats

Cited by 3 publications

References 20 publications

Impact of Foeniculum vulgare Fortified Diet on Coagulation Profile and Some Biochemical Parameters

Impact of Foeniculum vulgare Fortified Diet on Coagulation Profile and Some Biochemical Parameters

Potential nephroprotective phytochemicals: Mechanism and future prospects

Hepatotoxicity and mitochondrial dysfunction after lead (Pb) exposure and the protective effect of fennel essential oil of this toxicity in Wister rats

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