Aim:To evaluate the antiamnesic and antidepressant effect of Foeniculum vulgare whole crushed seeds. Study Design: Laboratory based randomized control study. Place and Duration of Study: Methodology: Thirty swiss albino mice and wistar rats were divided equally in three groups. Control group was fed on standard rodent diet, group 2 was fed on 2% Foeniculum vulgare diet and group 3 was given 4% Foeniculum vulgare diet. Antidepressant activity was assessed using forced swimming test. Memory enhancement effect was evaluated by stationary rod test, passive avoidance test and water maze test. Abbas et al.; JAMMR, 32(1): 131-138, 2020; Article no.JAMMR.54564 132 Results: Increased duration of struggling time was noted in both group 2 and group 3 as compared to control in forced swimming test. Decrease in time to reach platform in both water maze and stationary rod test was recorded in both the study group (group 2 & 3). Increase in step through latency was also seen in group 2 and group 3 as compared to control group. Conclusion: The results showed the memory enhancing and antidepressant actions of Foeniculum. Original Research Article
Aims: Coagulation profile shows the clotting ability of blood. Biochemical tests indicate health status of vital organs such as liver, heart and kidneys. Herbal products are being assessed for their role in affecting these parameters. We evaluated role of Foeniculum vulgare incorporated diet on coagulation profile and some important biochemical parameters. Study Design: Laboratory centred randomized controlled trial. Place and Duration of Study: Pharmacology Department of University of Karachi, Karachi between June 2018 and September 2018. Methodology: After selecting 30 healthy rabbits of either sex, we placed them in three groups; Control, 2% Foeniculum vulgare and 4% Foeniculum vulgare group. Control group was given standard diet whereas; 2% and 4% Foeniculum vulgare groups were maintained on standard diet containing 2% and 4% Foeniculum vulgare crushed seeds. Coagulation profile and some biochemical parameters were done after interval of a month, for two months. Results: Platelet count and fibrinogen increased while activated partial thromboplastin time (APTT) levels decreased in both the study groups animals as compared to control, while blood urea nitrogen (BUN), creatinine phosphokinase (CPK) and lactate dehydrogenase (LDH) elevation was noted both Foeniculum vulgare groups but within normal range. Conclusion: Foeniculum vulgare may have some role in affecting coagulation and biochemical profile These parameters, however, need clinical trial to validate reliability.
Aims: Anemia is prime health issue of the population in developing region of world mostly due to dietary deficiencies and poor sanitation. Supplementary medicines as well as iron rich foods are utilized to combat this problem. Herbal products also have value in such diets. We evaluated role of Foeniculum vulgare incorporated diet on hemoglobin concentration and related indices. Study Design: laboratory centred randomized controlled trial. Place and Duration of Study: Pharmacology Department of University of Karachi, Karachi between June 2018 and September 2018. Methodology: After selecting 30 healthy rabbits of either sex, we placed them in three groups; Control, 2% Foeniculum vulgare and 4% Foeniculum vulgare group. Control group, 2% and 4% Foeniculum vulgare groups were maintained on standard rodent diet, standard rodent diet containing 2% and 4% Foeniculum vulgare crushed seeds, respectively. Complete blood count of all rabbits was done twice after interval of a month. Results: In comparison to control group, hemoglobin levels increased in both the study groups, while leucocyte count (WBC) increase was noted only in 4% Foeniculum vulgare group. Conclusion: Foeniculum vulgare may have some role in maintenance of hemoglobin levels if not improving it.
Aims: To study the role of two combination therapies in the treatment of rheumatoid arthritis. Study Design: This an open-label, randomized 180-days clinical trial. Place and Duration of Study: This study was conducted in the Department of Pharmacology and Therapeutics, BMSI and Medical unit ward 6. Methodology: Eighty-nine patients were enrolled (69 women, 20 men; age range 28-62 years). A and B were the groups assigned to the patients. MTX 7.5-20 mg/ week orally and SSZ 10-20 mg / day orally as maximally tolerated were prescribed to the 55 patients of group A. MTX 7.5-20 mg/ week orally and HCQ 200 mg twice daily were prescribed to the 54 patients of group B.. Results: When we compared group A with group B, group A showed major progress in mean swollen joint count (1.9 ± 0.97) as compared to group B (2.7 ± 1.78). Group B showed major progress in mean physician’s global assessment (2.7 ± 0.92) as compared to group A (3.8 ± 1.22). For that reason, our study showed that patients receiving both the combinations responded equally in terms of efficacy but the combination of MTX and HCQ is better tolerated than the combination of MTX and SSZ. Conclusion: Both combinations of MTX & SSZ and MTX & HCQ were equally effective but the combination of MTX & HCQ was superior in terms of tolerability than the combination of MTX and SSZ.
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