Impact of Foeniculum vulgare Fortified Diet on Coagulation Profile and Some Biochemical Parameters

Abstract

Aims: Coagulation profile shows the clotting ability of blood. Biochemical tests indicate health status of vital organs such as liver, heart and kidneys. Herbal products are being assessed for their role in affecting these parameters. We evaluated role of Foeniculum vulgare incorporated diet on coagulation profile and some important biochemical parameters.
 Study Design: Laboratory centred randomized controlled trial.
 Place and Duration of Study: Pharmacology Department of University of Karachi, Karachi between June 2018 and September 2018.
 Methodology: After selecting 30 healthy rabbits of either sex, we placed them in three groups; Control, 2% Foeniculum vulgare and 4% Foeniculum vulgare group. Control group was given standard diet whereas; 2% and 4% Foeniculum vulgare groups were maintained on standard diet containing 2% and 4% Foeniculum vulgare crushed seeds. Coagulation profile and some biochemical parameters were done after interval of a month, for two months.
 Results: Platelet count and fibrinogen increased while activated partial thromboplastin time (APTT) levels decreased in both the study groups animals as compared to control, while blood urea nitrogen (BUN), creatinine phosphokinase (CPK) and lactate dehydrogenase (LDH) elevation was noted both Foeniculum vulgare groups but within normal range.
 Conclusion: Foeniculum vulgare may have some role in affecting coagulation and biochemical profile These parameters, however, need clinical trial to validate reliability.

Protective and antidote effect of Foeniculum vulgare against Sodium Arsenite induced hepatotoxicity and testicular toxicity in Charles Foster rats

“…Hormones are an essential part of the system that regulates the major functions of the body. Testosterone and the luteinizing hormones are the important hormones of the male reproductive system (Abbas et al, 2020). In the present study, there was a significant (p<0.001) decrease in the testosterone levels, while a significant increase (p<0.001) in the luteinizing hormone was observed in the arsenic-treated groups in comparison to the control group of rats.…”

Neuroprotective effect of Foeniculum vulgare essential oil in developing Wistar rats exposed to manganese chloride

“…Similarly, an earlier study showed that linolenic acid, a constituent of F. vulgare, increases the amount of neurotransmitters in the brain (Acar et al, 2002). The antidepressant action of Foeniculum vulgare seeds has been shown in a study by Abbas et al (2020), on albino smiley moths with different concentrations (2% and 4%). These results suggest that fennel oil alone may be potential alternatives to antidepressant drugs to treat depression.…”

“…The traditional use of this plant has proven its beneficial effect as an antidepressant (Abbas et al, 2019;Abbas et al, 2020). Similarly, the aromatic essential oil of Foeniculum vulgare has been successfully used for the management of depression (Glory et al, 2015).…”

Role of Fennel (Foeniculum vulgare) Seed Powder in Increasing Testosterone and IGF1 Gene Expression in the Testis of Lamb

“…Abbas et al studied how serum sex hormones and fertility in mice and rabbits are affected by Foeniculum vulgare. 45 They demonstrated that the use of 2% and 4% Foeniculum vulgare in the diet of male rabbits causes a significant increase in serum testosterone levels. One of the compounds of Foeniculum vulgare is isoflavones; this compound inhibits the activity of 5α-reductase and aromatase P450 enzymes.…”