The Role of Medicinal Herbs in Angiogenesis Related Diseases

Clinical Outcomes from Tamoxifen Drug-herb Interactions

“…It should be adjusted the dose of tamoxifen if the patient insist in the intake, otherwise the bioactivation of Tamoxifen will be compromise. No data Angiogenic/ Antiangiogenic [23,24] Inhibitor CYP 3A4, Inhibitor CYP 2A6 ⤔, * [18] Astragalus /isoflavones Estrogen-like activity in Caucasians/ antiestrogenic for Asians [14] Angiogenic [24] No data Angelica Angiogenic [24] Black cohosh/isoflavones and caffeic derivative acids Estrogen-like activity in Caucasians Antiestrogenic for Asians [10,14] Small inhibitory effect on CYP2D6;possible inhibitory effect on CYP3A4 [25] Coriolus many fruits and vegetables, wine, bee pollen and propolis, making them potential inhibitors of 2C9 and CYP3A4 [20]. From the medicinal plants cited above, in our clinical reports we had DHI with Aloe vera, Geranium and Verbena, that are in line with this hypothesis, reinforcing the potential risk and alerts should be given by the health professionals to the patients about these possible situations.…”

“…Angiogenesis is the growth of neovessels from existing vasculature and angiogenic diseases result from new blood vessels growing either excessively, as in cancer, diabetic retinopathy and psoriasis. It is consider a key step in tumor growth, invasion and metastasis [23].…”

“…Others as Astragalus membranaceus, Angelica sinensis, Rehmannia glutinosa (Jun) and Salvia miltiorrhiza are potential angiogenic plants and the risk associated to the intake is more clear [23,24].…”