Dose-dependent cholesterol-lowering effect of a mayonnaise-type product with a main component of diacylglycerol-containing plant sterol esters

Saito, Shinichiro; Takeshita, M; Tomonobu, Kazuichi; Kudo, Naoto; Shiiba, Daisuke; Hase, Tadashi; Tokimitsu, Ichiro; Yasukawa, Takuji

doi:10.1016/j.nut.2005.05.013

Cited by 23 publications

(17 citation statements)

References 15 publications

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“…This result is consistent with several studies of chronic DAG consumption, from 4 to 24 weeks duration, in normal subjects (36)(37)(38)(39). However, in patients with T2DM, Yamamoto et al (51) found a significant reduction in fasting TG from baseline after 12 weeks of a DAG-enriched diet compared with a TAG-based diet.…”

Section: Discussionsupporting

confidence: 87%

“…Lower PPTG levels have also been observed after acute administration of DAG to healthy humans (31)(32)(33), people with T2DM (34), and individuals with IR (35). On the other hand, several long-term studies in humans did not demonstrate any effects of DAG oil on fasting TG levels (36)(37)(38)(39), even when there was a greater weight loss on the DAG diet treatment. None of these latter studies examined PPTG.…”

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confidence: 99%

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Effects of a 1,3-diacylglycerol oil-enriched diet on postprandial lipemia in people with insulin resistance

Reyes

Yasunaga

Rothenstein

et al. 2008

Journal of Lipid Research

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Postprandial hypertriglyceridemia is common in individuals with insulin resistance, and diets enriched in 1,3-diacylglycerol (DAG) may reduce postprandial plasma triglycerides (PPTGs). We enrolled 25 insulin-resistant, nondiabetic individuals in a double-blind, randomized crossover trial to test the acute and chronic effects of a DAG-enriched diet on PPTG. Participants received either DAG or triacylglycerol (TAG) oil, in food products, for 5 weeks. Fasting lipids, and two separate postprandial tests, one with DAG oil and one with TAG oil, were performed at the end of each 5 week diet period. We found no acute or chronic effects of DAG oil on PPTG. Thus, neither the DAG oil PPTG (h/mg/dl) on a chronic TAG diet [area under the curve (AUC) 5 503 6 439] nor the TAG oil PPTG on a chronic DAG diet (AUC 5 517 6 638) was different from the TAG oil PPTG on a chronic TAG diet (AUC 5 565 6 362). Five weeks of a DAG-enriched diet had no acute or chronic effects on PPTG in insulin-resistant individuals. We suggest further studies to evaluate the effects of DAG on individuals with low and high TG levels.-Reyes, G

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Section: Discussionsupporting

confidence: 87%

mentioning

confidence: 99%

Effects of a 1,3-diacylglycerol oil-enriched diet on postprandial lipemia in people with insulin resistance

Reyes

Yasunaga

Rothenstein

et al. 2008

Journal of Lipid Research

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“…Based on the assumption that an amount more than the effective dose (daily intake of 0.4 g PSE/10 g DAG) obtained in our previous study [7] is frequently ingested in general eating habits, the dose in the present study was set to a threefold excess of the effective dose (1.2 g PSE/30 g DAG/45 g mayonnaise-type product). The daily ingestion of 30 g of test fat was considered to represent a substantial mental and physical burden, however, because it corresponds to 50% of the mean daily fat intake of the Japanese population (approx.…”

Section: Discussionmentioning

confidence: 99%

“…In our previous study, 0.4 g/day of plant sterol esters (PSE) dissolved in 10 g/day of DAG was administered to healthy and mildly hypercholesterolemic subjects for 4 weeks, resulting in significantly lower cholesterol levels [7] . Thus, DAG oil-containing PSE would be expected to maintain an appropriate serum cholesterol level as well as decrease the risk of arteriosclerotic disorders.…”

Section: Introductionmentioning

confidence: 99%

Serum Retinol, α-Tocopherol, and β-Carotene Levels Are Not Altered by Excess Ingestion of Diacylglycerol-Containing Plant Sterol Esters

Saito¹,

Tomonobu²,

Kudo³

et al. 2006

Ann Nutr Metab

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Background: Diacylglycerol (DAG) suppresses the postprandial increase in serum triglycerides, and has antiobesity effects. On the other hand, plant sterol esters (PSE) lower serum cholesterol levels in hypercholesterolemia. Thus, DAG-containing PSE (PSE/DAG) would be expected to maintain an appropriate serum cholesterol level and decrease the risk of arteriosclerotic disorders. Several recent studies, however, report negative effects of PSE on serum fat-soluble (pro)vitamin levels. The objective of this study was to investigate the effect of PSE/DAG on serum retinol, β-carotene, and α-tocopherol levels using a threefold excess of the effective dose obtained in our previous study. Methods: A randomized placebo-controlled double-blind parallel study was performed in healthy and mildly hypercholesterolemic subjects, in which the subjects ingested 1.2 g PSE/30 g DAG for 2 weeks in the form of mayonnaise-type products. Triacylglycerol (TAG) mayonnaise was used as a control. Result: There were no subjective adverse effects or changes in serum retinol, α-tocopherol, and β-carotene levels, abdominal symptoms, hematologic values, or blood biochemical values. Conclusion: Ingestion of a threefold excess of PSE/DAG for 2 weeks had no adverse effects compared to ingestion of conventional TAG mayonnaise.

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“…In the four remaining studies (Matvienko et al, 2002;Deveraj et al, 2004;Saito et al, 2006;Seki et al, 2003b) it took longer than two weeks before the maximum reduction was reached.…”

Section: Minimum Duration For Effect Of Plant Sterols/stanolsmentioning

confidence: 97%

Scientific Opinion on the substantiation of a health claim related to 3 g/day plant sterols/stanols and lowering blood LDL-cholesterol and reduced risk of (coronary) heart disease pursuant to Article 19 of Regulation (EC) No 1924/2006

Products¹

2012

EFSA Journal

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Following an application from Unilever PLC and Unilever NV, submitted pursuant to Article 19 of Regulation (EC) No 1924/2006 via the Competent Authority of the United Kingdom, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of an application to modify the conditions of use of an authorised Article 14 claim related to 1.5 – 3.0 g plant sterols/stanols per day and lowering blood LDL‐cholesterol by 7 – 12 % and reduced risk of (coronary) heart disease. The applicant has further requested that the minimum duration to obtain the effect be one to two weeks. The applicant provided a published systematic review and meta‐analysis that evaluated the comparative efficacy of plant sterols and plant stanols for lowering blood LDL‐cholesterol in healthy and hypercholesterolaemic subjects and an unpublished meta‐analysis on 27 randomised controlled human studies on the LDL‐lowering efficacy at a dose range between 2.6 and 3.4 g per day. On the basis of the data presented, the Panel concludes that plant sterols and stanol esters at daily intakes ranging from 1.5 to 3.0 g plant sterols/stanols in matrices approved by Regulation (EC) No 376/2010 (yellow fat spreads, dairy products, mayonnaise and salad dressings) have a similar efficacy on blood LDL‐cholesterol lowering, that plant sterols and stanol esters at a daily intake of 3 g (range 2.6 g to 3.4 g) plant sterols/stanols in matrices approved by Regulation (EC) No 376/2010 lower LDL‐cholesterol by 11.3 % (95 % CI: 10.0 – 12.5), and that the minimum duration required to achieve the maximum effect of plant sterols and stanols on LDL‐cholesterol lowering is two to three weeks.

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Dose-dependent cholesterol-lowering effect of a mayonnaise-type product with a main component of diacylglycerol-containing plant sterol esters

Cited by 23 publications

References 15 publications

Effects of a 1,3-diacylglycerol oil-enriched diet on postprandial lipemia in people with insulin resistance

Effects of a 1,3-diacylglycerol oil-enriched diet on postprandial lipemia in people with insulin resistance

Serum Retinol, α-Tocopherol, and β-Carotene Levels Are Not Altered by Excess Ingestion of Diacylglycerol-Containing Plant Sterol Esters

Scientific Opinion on the substantiation of a health claim related to 3 g/day plant sterols/stanols and lowering blood LDL-cholesterol and reduced risk of (coronary) heart disease pursuant to Article 19 of Regulation (EC) No 1924/2006

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