2012
DOI: 10.2903/j.efsa.2012.2693
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Scientific Opinion on the substantiation of a health claim related to 3 g/day plant sterols/stanols and lowering blood LDL-cholesterol and reduced risk of (coronary) heart disease pursuant to Article 19 of Regulation (EC) No 1924/2006

Abstract: Following an application from Unilever PLC and Unilever NV, submitted pursuant to Article 19 of Regulation (EC) No 1924/2006 via the Competent Authority of the United Kingdom, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of an application to modify the conditions of use of an authorised Article 14 claim related to 1.5 – 3.0 g plant sterols/stanols per day and lowering blood LDL‐cholesterol by 7 – 12 % and reduced risk of (coronary) hea… Show more

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Cited by 73 publications
(23 citation statements)
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“…The question remains as to how relevant this enrichment could be from a healthy point of view. In terms of uptake, experiments concerning the controlled enrichment of EVOO indicate that normal amounts of PC in EVOO are still enough concentrated to theoretically provide bioactive molecules at amounts claimed to lower blood LDL oxidation and thus the risk of cardiovascular diseases [ 110 ], i.e., at the minimum level of supplementation of 5 mg per day [ 82 ]. However, as analyses of bioavailability are very limited, controlled clinical trials are crucial for confirmation.…”
Section: Discussionmentioning
confidence: 99%
“…The question remains as to how relevant this enrichment could be from a healthy point of view. In terms of uptake, experiments concerning the controlled enrichment of EVOO indicate that normal amounts of PC in EVOO are still enough concentrated to theoretically provide bioactive molecules at amounts claimed to lower blood LDL oxidation and thus the risk of cardiovascular diseases [ 110 ], i.e., at the minimum level of supplementation of 5 mg per day [ 82 ]. However, as analyses of bioavailability are very limited, controlled clinical trials are crucial for confirmation.…”
Section: Discussionmentioning
confidence: 99%
“…In this case, they specify that must be O-carboxymethyl Chitosan, but they do not limit the source, so the mushroom derived chitosan may be considered, with the potential advantage of less allergenic issues compared to crustaceous source [196]. Concerning sterols and stanol esters the panel concludes that sterols and stanol esters at a daily intake of 3 g (range 2.6-3.4 g), but in this case, they regulate just for the plant sterols and stanol esters and also for the matrices of application so sterols/stanols they can only be applied in matrices approved by the Regulation (EC) No 376/2010 (yellow fat spreads, dairy products, mayonnaise and salad dressings) lower LDL-cholesterol by 11.3% (95% CI: 10.0-12.5) [197,198].…”
Section: Plant Sterols and Plant Stanolsmentioning
confidence: 99%
“…Such occurrences can arise spontaneously or be influenced by external factors (e.g., shear, ionic charges, temperature, light) [ 11 , 12 , 13 , 14 ]. The application of low molecular weight gelators (LMOGs) has been gaining attention, due to the gelation mechanisms and also because of the existence of new food-grade ingredients with gelling capability [ 15 ]. Bot and Agterof reported on γ-oryzanol and phytosterol combinations, showing that sterols (e.g., β-sitosterol, cholesterol, dihydrochlesterol, ergosterol, stigmasterol, cholestanol) can associate with γ-oryzanol to form oleogels [ 16 , 17 ].…”
Section: Introductionmentioning
confidence: 99%