Effects of a 1,3-diacylglycerol oil-enriched diet on postprandial lipemia in people with insulin resistance

Abstract

Postprandial hypertriglyceridemia is common in individuals with insulin resistance, and diets enriched in 1,3-diacylglycerol (DAG) may reduce postprandial plasma triglycerides (PPTGs). We enrolled 25 insulin-resistant, nondiabetic individuals in a double-blind, randomized crossover trial to test the acute and chronic effects of a DAG-enriched diet on PPTG. Participants received either DAG or triacylglycerol (TAG) oil, in food products, for 5 weeks. Fasting lipids, and two separate postprandial tests, one with DAG oil and one with TAG oil, were performed at the end of each 5 week diet period. We found no acute or chronic effects of DAG oil on PPTG. Thus, neither the DAG oil PPTG (h/mg/dl) on a chronic TAG diet [area under the curve (AUC) 5 503 6 439] nor the TAG oil PPTG on a chronic DAG diet (AUC 5 517 6 638) was different from the TAG oil PPTG on a chronic TAG diet (AUC 5 565 6 362). Five weeks of a DAG-enriched diet had no acute or chronic effects on PPTG in insulin-resistant individuals. We suggest further studies to evaluate the effects of DAG on individuals with low and high TG levels.-Reyes, G

Effects of Nutrients on Postprandial Lipemia

“…Comparisons of the effect of diets rich in n-6 PUFA with MUFA showed lower or comparable magnitude of postprandial lipemia [16,21]. Compared with a diet rich in triacylglycerol, a related 1,3 diacylglycerol-enriched diet did not promote a different postprandial lipemia response in humans [45].…”

Enzymatic synthesis of 1,3-dicaproyglycerol by esterification of glycerol with capric acid in an organic solvent system

“…The adjustment provided by this model could explain 94.03% of the variation in the dicaprin yield, and the value of the adjusted R 2 coefficient was 92.32. Equation (10) was obtained as a result of this multiple regression, and Fig. 5b shows the response surface plot for this model.…”

“…The latest reports on the nutritional benefits of DAG have renewed the interest on this research topic. DAG, particularly the 1,3-isoform, has been confirmed as having certain nutritional benefits such as the ability to reduce serum triacylglycerol (TAG) concentration, bodyweight and visceral fat [8][9][10][11][12][13]. There is no significant difference in energy value and absorption coefficient between DAG and TAG [14].…”

Pemurnian diasilgliserol dari produk gliserolisis minyak sawit mentah dengan kromatografi kolom Purification of diacylglycerol from glycerolysis products of crude palm oil using column chromatography

“…Diasilgliserol dikenal sebagai minyak sehat (healthy oil) karena dapat mengurangi trigliserida (TG) dalam serum darah, mencegah akumulasi lemak dalam tubuh, dan memperbaiki rasio kolesterol serum darah (Yasunaga et al, 2001). Reyes et al (2008) melaporkan bahwa konsumsi minyak yang diperkaya dengan DAG selama lima minggu tidak meningkatkan kandungan plasma TG sehingga dapat mengurangi risiko serangan jantung. Harga minyak sehat dapat mencapai 5-7 kali dari harga minyak goreng biasa.…”