Does sucrose influence the properties of DMPC vesicles?

Киселев, М. А.; Wartewig, S.; Janich, Martin A.; Lesieur, P.; Kiselev, A.M.; Ollivon, Michel; Neubert, Reinhard H.H.

doi:10.1016/s0009-3084(02)00140-8

Cited by 37 publications

(24 citation statements)

References 37 publications

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“…SAXS was already applied to describe the influence of extrusion on the average number of bilayers (Jousma et al, 1987), but also to describe the electron density profile of different ULV systems from synthetic (Bouwstra et al, 1993;Hirai et al, 2003;Brzustowicz and Brunger, 2005), and natural origin (Castorph et al, 2010). Small-angle neutron scattering was also applied to study ULVs (Uhriková et al, 2008;Kiselev et al, 2003;Arleth and Vermehren, 2010), which exploits the large scattering length density contrast of protonated lipids and heavy water.…”

Section: Introductionmentioning

confidence: 99%

Characterization of the PEG layer of sterically stabilized liposomes: a SAXS study

Varga

Wacha

Vainio

et al. 2012

Chemistry and Physics of Lipids

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Synchrotron small-angle X-ray scattering analysis of the bilayer structure of a pharmacologically relevant sterically stabilized liposome system is presented. Describing the electron density profile of the bilayer with the superposition of Gaussian functions, the contribution of the poly(ethylene glycol) (PEG) layers to the total electron density was identified. The changes in the thickness of the PEG layer as well as the distribution of the PEG chains among the outer and inner leaflets of the bilayers were followed by changing the molar ratio of the PEG-lipid and the molar weight of the PEG molecule.

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Section: Introductionmentioning

confidence: 99%

Characterization of the PEG layer of sterically stabilized liposomes: a SAXS study

Varga

Wacha

Vainio

et al. 2012

Chemistry and Physics of Lipids

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“…This technique is widely utilized for investigation of unilamellar phospholipid vesicles (ULVs) with different chemical compositions in large water excess, see [3,4,5,6] and references therein. Investigations of the structure and properties of multilamellar and unilamellar vesicles are of great interest because they can provide an insight to the fundamental properties of biological and artificial lipid membranes.…”

Section: Introductionmentioning

confidence: 99%

The Small-Angle Neutron Scattering Data Analysis of the Phospholipid Transport Nanosystem Structure

Zemlyanaya

Киселев

Zhabitskaya

et al. 2018

J. Phys.: Conf. Ser.

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Abstract. The small-angle neutron scattering technique (SANS) is employed for investigation of structure of the phospholipid transport nanosystem (PTNS) elaborated in the V.N.Orekhovich Institute of Biomedical Chemistry (Moscow, Russia). The SANS spectra have been measured at the YuMO small-angle spectrometer of IBR-2 reactor (Joint Institute of Nuclear Research, Dubna, Russia). Basic characteristics of polydispersed population of PTNS unilamellar vesicles (average radius of vesicles, polydispersity, thickness of membrane, etc.) have been determined in three cases of the PTNS concentrations in D2O: 5%, 10%, and 25%. Numerical analysis is based on the separated form factors method (SFF). The results are discussed in comparison with the results of analysis of the small-angle X-ray scattering spectra collected at the Kurchatov Synchrotron Radiation

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“…The small angle scattering of neutrons (SANS) and of Xrays (SAXS) are known as powerful tools for the nanosystems structure investigation. SANS and SAXS measurements are well suited for the analysis of the structure of the polydispersed populations of unilamellar vesicles (ULVs) of phospholipids in water solutions of disaccharides [3][4][5][6]. For this analysis, we utilize the separated form factors method (SFF) [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Determination of the Vesicular Systems Parameters: Parallel Implementation and Analysis of the PTNS Vesicle Structure

et al. 2018

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Abstract. Parameters of the phospholipid vesicular systems are determined by means of minimization of the discrepancy between experimental data on the small angle scattering intensity and the numerical results within the frame of the separated form factors method. Effectiveness of parallel implementation is tested at the cluster HybriLIT. Results of numerical analysis of small angle neutron scattering data on polydispersed population of unilamellar vesicles of phospholipid transport nanosystem are presented.

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Does sucrose influence the properties of DMPC vesicles?

Cited by 37 publications

References 37 publications

Characterization of the PEG layer of sterically stabilized liposomes: a SAXS study

Characterization of the PEG layer of sterically stabilized liposomes: a SAXS study

The Small-Angle Neutron Scattering Data Analysis of the Phospholipid Transport Nanosystem Structure

Determination of the Vesicular Systems Parameters: Parallel Implementation and Analysis of the PTNS Vesicle Structure

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