Determination of the Vesicular Systems Parameters: Parallel Implementation and Analysis of the PTNS Vesicle Structure

Bashashin, M. V.; Zemlyanaya, E. V.; Zhabitskaya, Evgeniya; Киселев, М. А.; Sapozhnikova, T. A.

doi:10.1051/epjconf/201817305003

Cited by 3 publications

(1 citation statement)

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“…In the photo, one can see discrete particles that are predominantly spherical and/or rod-shaped. Previously, a combination of two methods-small-angle neutron scattering in the range of PhTNS concentration in heavy water of 5-25% by weight and small-angle scattering of X-ray synchrotron radiation in several concentrations in water-was used to determine the single-layer vesicular structure of phospholipid transport nanosystem (PhTNS) [23,24]. It was found that the size of vesicles decreased with an increase in the maltose concentration and was about 27.2 + 0.2 nm at a concentration of 20%.…”

Section: Transmission Electron Microscopymentioning

confidence: 99%

Drug Transport System Based on Phospholipid Nanoparticles: Production Technology and Characteristics

et al. 2022

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One of the current trends in modern pharmaceuticals is the supply of drugs by transport systems. The use of delivery systems allows to increase the therapeutic efficacy, tolerability, and safety of drug therapy. Liposomes, polymer nanoparticles, carbon nanoparticles, blood cells, metal nanoparticles, oxides, etc., are used as transport systems. This work is aimed at obtaining a finished technological product based on soy phospholipids with particle size in the nanometer range and reproducible characteristics (size, charge). For this purpose, we carried out investigations to select the optimal conditions of technological process. The developed technology makes it possible to obtain phospholipid nanoparticles without the use of any solubilizers and/or surfactants, which increases its practical relevance for further work. The versatility of the technology is demonstrated by the example of incorporation of drugs of various chemical nature and pharmacotherapeutic groups.

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Section: Transmission Electron Microscopymentioning

confidence: 99%