Does Helicobacter pylori play a role in etiology of nasal polyposis?

Özcan, Cengiz; Polat, Ayşe; Otağ, Feza; Görür, Kemal

doi:10.1016/j.anl.2008.09.007

Cited by 17 publications

(19 citation statements)

References 24 publications

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“…Our results were in agreement with Ozcan et al [16] and Szczygelski et al [17] who used immunohistochemistry (IHC) and RUT, respectively, and both of them did not Wnd H. pylori in tissue specimens of patients suVering from nasal polyposis. Kim et al [14] evaluated patients suVering from chronic rhinosinusitis using IHC and RUT which demonstrated a reservoir role for intranasal transmission of H. pylori and did not show any correlation between severity of rhinosinusitis and the presence of H. pylori.…”

Section: Discussionsupporting

confidence: 93%

Investigating Helicobacter pylori in nasal polyposis using polymerase chain reaction, urease test and culture

Nemati

Mojtahedi

Naghavi

et al. 2011

Eur Arch Otorhinolaryngol

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The aim of this study was to identify the presence of Helicobacter pylori in nasal polyp specimens of patients with nasal polyposis. A cross-sectional study with control group was performed on fresh tissue samples from 25 patients with nasal polyps, and 25 persons with concha bollusa (control group). Patients with symptoms of gastroesophageal reflux (GERD) were not enrolled. Samples were studied by three methods: polymerase chain reaction (PCR), culture, and urease test. All the diagnostic tests were negative for H. pylori in both the case and control groups. In conclusion, there was no association between H. pylori and nasal polyposis in patients without GERD signs or symptoms in our study, and further studies are needed to assess other potential factors that may influence the development of nasal polyposis.

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Section: Discussionsupporting

confidence: 93%

Investigating Helicobacter pylori in nasal polyposis using polymerase chain reaction, urease test and culture

Nemati

Mojtahedi

Naghavi

et al. 2011

Eur Arch Otorhinolaryngol

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“…Morinaka et al [12] in their study showed significant positivity with PCR and IHC as compared to urease test and culture. However, Ozcan et al [18] could not detect H. pylori in nasal polyps by IHC.…”

Section: Resultsmentioning

confidence: 97%

“…It has also been identified in human dental plaques, saliva, in oral lesions and ulcers, and in adenotonsillar tissue [10,11]. Later studies have detected H. pylori in nasal mucosa of chronic rhinosinusitis [12][13][14][15] and nasal polyps [16][17][18][19][20][21][22][23][24] with variable results, which can be attributed to different sample size and detecting methods.…”

Section: Introductionmentioning

confidence: 99%

Detection of Helicobacter pylori in Nasal Polyps

Bansal

Sharma

Agarwal

et al. 2016

Head and Neck Pathol

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To detect the presence of Helicobacter pylori in nasal polyps. A case-control study was conducted enrolling 35 patients with nasal polyps (cases) and patients undergoing septoplasty (controls). Fresh tissue samples were used for urea broth test and imprint cytology, while formalin fixed tissue sections were used for morphology, special stains and immunohistochemistry for H. pylori. Fresh stool samples from both groups were tested to correlate the gastrointestinal status. H. pylori was detected in 40.0 % (14/35) of cases and 8.5 % of controls (3/35) (p = 0.004) by immunohistochemistry. Amongst cases, eight were positive with urea broth test, six with imprint cytology (Giemsa stain), three with H & E, and nine with modified McMullen's stain. Hyperplasia of the lining epithelium and lymphoid aggregates were significantly noticed in nasal polyps positive for H. pylori. Stool antigen test was positive in subjects who were positive for H. pylori in the nasal mucosa. There appears to be an association between H. pylori and nasal polyps. Immunohistochemistry is more sensitive and specific method to detect H. pylori.H. pylori induced inflammatory tissue reaction pattern indicates a possible causal association. Further studies are needed to prove the causal relationship between H. pylori and nasal polyps.

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“…found H. pylori in six of 23 specimens by urease test and by histochemical analysis with Giemsa staining [42], Ozcan et al. detected H. pylori only in one of 25 specimens by each of these methods [43]. By using a questionnaire, another group has shown, in a prospective study that H. pylori eradication chronic nonspecific pharyngeal symptoms [44] but the mechanism of this benefit should be better investigated.…”

Section: Respiratory and Ear Nose And Throat (Ent) Diseasesmentioning

confidence: 99%

Helicobacters and Extragastric Diseases

et al. 2009

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For two decades, Helicobacter pylori has been considered as the culprit in many extragastric manifestations. However, for several of these supposed associations the hypothesis of an etiological role has not yet been fully investigated. This may be due to a series of factors linked to the epidemiological features of the studies and to the diseases investigated. This review attempts to highlight the main reported associations of H. pylori with extragastric manifestations during the last year. The most convincing data arise in the field of idiopathic thrombocytopenic purpura (ITP) and sideropenic anemia. Long-term follow-up studies have shown that 50% of subjects with ITP maintain a hematological response after H. pylori eradication. There is also growing evidence of the role of H. pylori in other diseases, including ischemic heart disease even though results are not conclusive.

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Does Helicobacter pylori play a role in etiology of nasal polyposis?

Cited by 17 publications

References 24 publications

Investigating Helicobacter pylori in nasal polyposis using polymerase chain reaction, urease test and culture

Investigating Helicobacter pylori in nasal polyposis using polymerase chain reaction, urease test and culture

Detection of Helicobacter pylori in Nasal Polyps

Helicobacters and Extragastric Diseases

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