Distribution of molecular breast cancer subtypes among Algerian women and correlation with clinical and tumor characteristics: A population-based study

Abstract

For the first time, we report the distribution of molecular breast cancer subtypes and their associations with some clinicopathological characteristics in a large cohort of Algerian women. In our current study, the median age of diagnosis for all breast cancer subtypes was younger than the average age in Europe and America. Luminal A was the most common sub- type in our patients followed by TNBC. The proportion of luminal A subtype was lesser than reported in white women with breast cancer in Europe and America. The proportion of TNBC subtype in Algerian women was higher compared with Caucasian women of European ancestry. This study will contribute in developing optimal clinical trial protocols and personalized management strategies for Algerian breast cancer patients.

First report on molecular breast cancer subtypes and their clinico-pathological characteristics in Eastern Morocco: series of 2260 cases

“…In our study, invasive ductal carcinoma was the predominant histological type, which is similar to most previous studies on breast cancer [13, 28–30, 41–47]. Lobular invasive carcinoma was the second most common histological type accounting for 15.3% of all cases.…”

Molecular Profiling of Breast Carcinoma in Almadinah, KSA: Immunophenotyping and Clinicopathological Correlation

“…This finding is consistent with most worldwide reports from USA, Europe, Asia and Africa (Bhargava et al, 2009;Salhia et al, 2011;Zhu et al, 2014;Cherbal et al, 2015). As reported in many studies (Bhargava et al, 2009;Salhia et al, 2011;Zhu et al, 2014), luminal B was the second common subtype among our cohort.…”

“…Our work supports the well established aggressiveness of basal-like (triple negative) and HER-2 tumors, as these two subtypes were more frequent in younger age group, as reported in recent literature (Akbar et al, 2014;Kruijf et al, 2014); as well as presented with higher grades and poor prognostic parameters; in keeping with recent researches from Algeria and Italy (Caldarella et al, 2013;Cherbal et al, 2015). The Japanese researchers have also highlighted this phenomenon in a different way by concluding that the HER-2 positive subtypes (luminal B and HER-2 subtypes) had a significantly higher incidence of lymph node metastasis and lymphatic permeation, while the hormone receptor negative subtypes (HER-2 and TN subtypes) showed a significantly higher nuclear grade (Shibuta et al, 2011).…”

“…In contrast, a higher percentage between (22.9 -32% was reported in studies from China, Egypt and Nigeria (Huo et al, 2009;El-Hawary et al, 2012;Zheng et al, 2014). Regarding HER-2 subtype, the results from China and Algeria are consistent with our findings (Zhu et al, 2014;Cherbal et al, 2015). Whereas researchers from Pakistan have reported very high figures of HER-2 subtype (Akbar et al, 2014).…”

“…The findings from some of the recent studies are compared in Table 3. As observed, in our study the percentage of triple negative / basal subtype was represented by 15-20% as in many of the available studies in medical literature (Bhargava et al, 2009;Caldarella et al, 2013;Shomaf et al, 2013;Elesawy et al, 2014;Cherbal et al, 2015). In contrast, a higher percentage between (22.9 -32% was reported in studies from China, Egypt and Nigeria (Huo et al, 2009;El-Hawary et al, 2012;Zheng et al, 2014).…”