Health Disparities and Triple-Negative Breast Cancer in African American Women

Newman, Lisa A.; Kaljee, Linda

doi:10.1001/jamasurg.2017.0005

Cited by 255 publications

(229 citation statements)

References 73 publications

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“…It has been known for a number of decades that black patients with breast cancer in the United States have a higher population-based breast cancer mortality than white patients. [34, 35] This is not fully understood but may relate to differences in socio-economic access to care, genetic and lifestyle factors as well as a propensity to develop an aggressive breast cancer subtype (triple-negative breast cancer). When adjusted for age only due to the small number of events in an exploratory analysis, our data indeed indicated that black patients had significantly worse OS compared to white patients (results not shown).…”

Section: Discussionmentioning

confidence: 99%

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Racial disparities in the rate of cardiotoxicity of HER2‐targeted therapies among women with early breast cancer

Litvak

Batukbhai

Russell

et al. 2018

Cancer

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Section: Discussionmentioning

confidence: 99%

“…Future studies with larger patient cohorts could help determine better the association between development of cardiotoxicity and breast cancer outcomes in black patients. [34]…”

Section: Discussionmentioning

confidence: 99%

Racial disparities in the rate of cardiotoxicity of HER2‐targeted therapies among women with early breast cancer

Litvak

Batukbhai

Russell

et al. 2018

Cancer

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“…For example, although overall rates of HR‐negative/HER2‐positive breast cancers in API women are similar to the rates in other groups, an analysis of California women by Asian ethnic subgroup reported that Korean, Filipina, Chinese, and Southeast Asian women had a higher risk of HR‐negative/HER2‐positive breast cancers compared with NHW women, whereas Japanese and American Indian women had lower risk for this subtype . Racial and ethnic differences in breast cancer subtypes may reflect variation in the prevalence of breast cancer risk factors, particularly reproductive factors, which are most strongly associated with HR‐positive breast cancers but also appear to reflect ancestry‐related genetic variations …”

Section: Selected Findingsmentioning

confidence: 98%

Breast cancer statistics, 2017, racial disparity in mortality by state

DeSantis

Sauer

et al. 2017

CA A Cancer J Clinicians

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1,337

947

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In this article, the American Cancer Society provides an overview of female breast cancer statistics in the United States, including data on incidence, mortality, survival, and screening. Approximately 252,710 new cases of invasive breast cancer and 40,610 breast cancer deaths are expected to occur among US women in 2017. From 2005 to 2014, overall breast cancer incidence rates increased among Asian/Pacific Islander (1.7% per year), non-Hispanic black (NHB) (0.4% per year), and Hispanic (0.3% per year) women but were stable in non-Hispanic white (NHW) and American Indian/Alaska Native (AI/AN) women. The increasing trends were driven by increases in hormone receptor-positive breast cancer, which increased among all racial/ethnic groups, whereas rates of hormone receptor-negative breast cancers decreased. From 1989 to 2015, breast cancer death rates decreased by 39%, which translates to 322,600 averted breast cancer deaths in the United States. During 2006 to 2015, death rates decreased in all racial/ethnic groups, including AI/ANs. However, NHB women continued to have higher breast cancer death rates than NHW women, with rates 39% higher (mortality rate ratio [MRR], 1.39; 95% confidence interval [CI], 1.35-1.43) in NHB women in 2015, although the disparity has ceased to widen since 2011. By state, excess death rates in black women ranged from 20% in Nevada (MRR, 1.20; 95% CI, 1.01-1.42) to 66% in Louisiana (MRR, 1.66; 95% CI, 1.54, 1.79). Notably, breast cancer death rates were not significantly different in NHB and NHW women in 7 states, perhaps reflecting an elimination of disparities and/or a lack of statistical power. Improving access to care for all populations could eliminate the racial disparity in breast cancer mortality and accelerate the reduction in deaths from this malignancy nationwide. CA Cancer J Clin 2017;67:439-448. © 2017 American Cancer Society.

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“…For example, diabetes is more common in blacks than in other racial/ethnic groups and is associated with an increased risk of cancer death . In addition, some cancer‐associated genetic mutations and aggressive tumor characteristics are more common among persons of African ancestry, and likely contribute to racial disparities for some cancers . The underrepresentation of blacks and other racial/ethnic minorities in clinical trials may exacerbate survival disparities by limiting knowledge about the efficacy of therapeutic agents in diverse populations .…”

Section: Selected Findingsmentioning

confidence: 99%

Cancer statistics for African Americans, 2019

DeSantis

Miller

Sauer

et al. 2019

CA A Cancer J Clinicians

614

555

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In the United States, African American/black individuals bear a disproportionate share of the cancer burden, having the highest death rate and the lowest survival rate of any racial or ethnic group for most cancers. To monitor progress in reducing these inequalities, every 3 years the American Cancer Society provides the estimated number of new cancer cases and deaths for blacks in the United States and the most recent data on cancer incidence, mortality, survival, screening, and risk factors using data from the National Cancer Institute, the North American Association of Central Cancer Registries, and the National Center for Health Statistics. In 2019, approximately 202,260 new cases of cancer and 73,030 cancer deaths are expected to occur among blacks in the United States. During 2006 through 2015, the overall cancer incidence rate decreased faster in black men than in white men (2.4% vs 1.7% per year), largely due to the more rapid decline in lung cancer. In contrast, the overall cancer incidence rate was stable in black women (compared with a slight increase in white women), reflecting increasing rates for cancers of the breast, uterine corpus, and pancreas juxtaposed with declining trends for cancers of the lung and colorectum. Overall cancer death rates declined faster in blacks than whites among both males (2.6% vs 1.6% per year) and females (1.5% vs 1.3% per year), largely driven by greater declines for cancers of the lung, colorectum, and prostate. Consequently, the excess risk of overall cancer death in blacks compared with whites dropped from 47% in 1990 to 19% in 2016 in men and from 19% in 1990 to 13% in 2016 in women. Moreover, the black‐white cancer disparity has been nearly eliminated in men <50 years and women ≥70 years. Twenty‐five years of continuous declines in the cancer death rate among black individuals translates to more than 462,000 fewer cancer deaths. Continued progress in reducing disparities will require expanding access to high‐quality prevention, early detection, and treatment for all Americans.

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Health Disparities and Triple-Negative Breast Cancer in African American Women

Cited by 255 publications

References 73 publications

Racial disparities in the rate of cardiotoxicity of HER2‐targeted therapies among women with early breast cancer

Racial disparities in the rate of cardiotoxicity of HER2‐targeted therapies among women with early breast cancer

Breast cancer statistics, 2017, racial disparity in mortality by state

Cancer statistics for African Americans, 2019

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