Molecular Profiling of Breast Carcinoma in Almadinah, KSA: Immunophenotyping and Clinicopathological Correlation

Elkablawy, Mohamed A.; Albasry, Abdelkader M; Hussainy, Akbar Shah; Nouh, Magdy M.; Alhujaily, Ahmed Safar

doi:10.7314/apjcp.2015.16.17.7819

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…Junto com outros indicadores de prognóstico. A subtipagem molecular seria útil na previsão do prognóstico e tratamento do câncer de mama (ELKABLAWY et al, 2015).…”

Section: Resultados E Discussõesunclassified

A Importância Da Classificação Molecular No Prognóstico Do Câncer De Mama: Perspectivas Atuais

Rosa¹,

Teodoro²,

Marques³

et al. 2021

REFACER

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INTRODUÇÃO: O conhecimento sobre a classificação molecular do câncer de mama tem se tornado cada vez mais importante para definição de protocolos de tratamento, principalmente terapias alvo direcionadas. OBJETIVO: Descrever por meio da literatura a prevalência dos subtipos moleculares do câncer de mama, e sua relação com o prognóstico de indivíduos diagnosticados com esses tumores. METODOLOGIA: Trata-se de uma revisão integrativada literatura que incluiu artigos que investigaram os principais subtipos moleculares do câncer de mama (Luminal A, Luminal B, HER2/neu e Basa-like), e excluiu as publicações que investigaram apenas a expressão de marcadores moleculares como por exemplo p53 e HER2, ou que fizeram apenas a classificação histopatológica, sem considerar a classificação molecular para câncer de mama. RESULTADOS E DISCUSSÕES: Um total de 29,850casos de câncer de mama em mulheres, obteve o resultado do subtipo da classificação molecular, o mais prevalente foi o luminal A (51,3%%), seguido do luminal B (18%), HER2 (7,9%), basa-like (7,1%), a prevalência do triplo-negativo também foi investigada com (5,5%). O luminal A oferece o melhor prognóstico de todos os subtipos, os tumores luminais B são menos favoráveis do que os tumores luminais A, mas ainda menos agressivos do que os tumores do tipo basal. CONCLUSÃO: O luminal A continua sendo o subtipo molecular mais prevalente para o câncer de mama. O conhecimento sobre as classes moleculares do câncer de mama aumentou nos últimos anos, porém ainda existem dúvidas e dilemas que permanecem sem resposta e que são importantes para estudos futuros.Palavras-chaves: Câncer de mama. Diagnósticos moleculares. Prognóstico.

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“…Junto com outros indicadores de prognóstico. A subtipagem molecular seria útil na previsão do prognóstico e tratamento do câncer de mama (ELKABLAWY et al, 2015).…”

Section: Resultados E Discussõesunclassified

A Importância Da Classificação Molecular No Prognóstico Do Câncer De Mama: Perspectivas Atuais

Rosa¹,

Teodoro²,

Marques³

et al. 2021

REFACER

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“…1 In Saudi Arabia, BC ranks number one among the cancers in Saudi women and its incidence is increasing annually .In 2010, 1473 cases of BC were reported, with an age-standardized incidence rate of 24.9/100,000. 3 BC affects the younger age group and is detected at a more advanced stage. 4 Therefore, more diagnostic methods for detecting BC are required to be developed for providing a timely treatment, which could save many lives.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological Features and Metastatic Pattern of Triple Negative Breast Cancer Among Female Patients at a Tertiary Care Hospital

thoubaity¹

2021

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“…A total of 1,700,000 new cases of BC were discovered in 2012, with a global standardized mortality rate of 12.9 per 100,000 [1]. BC in Saudi Arabia differs from that in other countries; it affects younger age groups and is being discovered at more advanced stages [2]. In 2010, there were 1473 cases of BC in Saudi Arabia with an age-standardized incidence rate of 24.9 per 100,000, which accounts for approximately 27.4% of all newly diagnosed female cancers in that year [3].…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological Features and Metastatic Pattern of Triple-positive Breast Cancer Among Female Patients at a Tertiary Care Hospital

Alzahrani

Althoubaity

Alsobhi

et al. 2019

Cureus

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ObjectivesThe heterogenicity of breast cancer (BC) is determined by the status of human epidermal growth factor receptor 2 (HER2/neu), estrogen receptor (ER), and progesterone receptor (PR). Triple-positive BC (TPBC) expresses the amplification/overexpression of the HER2 pathway and is positive for ER and PR. This subtype has a distinct clinical behavior. However, very few studies are focused on TPBC. This study investigated the clinicopathological features and metastatic pattern of TPBC.MethodsA seven-year retrospective study was conducted at King Abdulaziz University Hospital in Jeddah, Kingdom of Saudi Arabia. All females with TPBC diagnosed between January 1, 2010, and June 30, 2017, were enrolled. Mean and standard deviation were calculated.ResultsFrom 1205 BC patients, the TPBC incidence was 10% (n = 124). The mean age at diagnosis was 51 years. On physical examination, a high tendency to show pathological skin changes was observed. Invasive ductal carcinoma was the most common histological type, presenting with a poorly differentiated histological grade (grade 3). Over a median two-year follow-up, the incidence of metastasis was 27.4% (n = 34). Bone was the most common site. The incidence of locoregional recurrence was 9.7%. Overall survival was 89.5%.ConclusionTPBC has an early tendency for metastasis and commonly affects the breast skin. BC should be approached based on the immunohistochemical diagnosis. We encourage more comprehensive studies to target TPBC for more insights into the heterogeneity of BC.

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Molecular Profiling of Breast Carcinoma in Almadinah, KSA: Immunophenotyping and Clinicopathological Correlation

Cited by 6 publications

References 24 publications

A Importância Da Classificação Molecular No Prognóstico Do Câncer De Mama: Perspectivas Atuais

A Importância Da Classificação Molecular No Prognóstico Do Câncer De Mama: Perspectivas Atuais

Clinicopathological Features and Metastatic Pattern of Triple Negative Breast Cancer Among Female Patients at a Tertiary Care Hospital

Clinicopathological Features and Metastatic Pattern of Triple-positive Breast Cancer Among Female Patients at a Tertiary Care Hospital

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