Distribution of Doxorubicin in the Bladder Wall and Regional Lymph Nodes After Bladder Submucosal Injection of Liposomal Doxorubicin in the Dog

Kiyokawa, Hideo; Igawa, Yasuhiko; Muraishi, Osamu; Katsuyama, Yoshihiko; Iizuka, Kojiro; Nishizawa, Osamu

doi:10.1097/00005392-199902000-00096

Cited by 3 publications

(4 citation statements)

References 12 publications

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“…Similarly, liposomes are taken up by lymphatic capillaries and lymph nodes draining the injection site after interstitial administration (Akamo et al 1997, Kiyokawa et al 1999, Harrington et al 2000, Oussoren & Storm 2001. A comparative study on sentinel lymph node identification showed that intra-mammary injection of liposomally encapsulated Patent Blue might provide greater intensity and a longer duration of node staining than aqueous Patent Blue (Dieter et al 2003).…”

Section: Discussionmentioning

confidence: 99%

“…injection (Oussoren & Storm 2001). This property has been used recently for the delivery of therapeutic and imaging agents to metastasized lymph nodes (Akamo et al 1997, Kiyokawa et al 1999, Harrington et al 2000. Liposome size is one of the most important factors that determines the rate and extent of liposome drainage from the injection site.…”

Section: Introductionmentioning

confidence: 99%

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Effect of small-sized liposomal Adriamycin administered by various routes on a metastatic breast cancer model

Jh¹

2005

Endocrine Related Cancer

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The antitumor effects of small-sized liposomal Adriamycin (LADR) administered by various routes were investigated in rabbits bearing well-developed VX2 tumors in the mammary gland. Rabbits received s.c. or i.v., or s.c. combined with i.v., injections of LADR 6 weeks after tumor implantation. The i.v. route showed a significant inhibitory effect on breast tumors and distant metastases. In comparison, metastases in axillary and mediastinal lymph nodes were more efficiently inhibited after s.c. injection. LADR administered concurrently by both the i.v. and s.c. routes produced satisfactory therapeutic activities on both primary breast tumors and metastases in local-regional lymph nodes, lungs and liver, as shown by slowed growth rates, decreased mRNA expression of proliferating cell nuclear antigen, and extensive necrosis and apoptosis of tumor cells. It is concluded that smallsized LADR administered s.c. provides reliable efficacy on lymphatic metastases of breast cancer and that the addition of treatment by the s.c. route to that by the conventional i.v. route can be recommended as a promising procedure to enhance chemotherapeutic effects in patients with metastatic breast cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of small-sized liposomal Adriamycin administered by various routes on a metastatic breast cancer model

Jh¹

2005

Endocrine Related Cancer

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“…As compared to free drug, submucosal injection of doxorubicin loaded liposome in bladder was shown to result in better distribution of drug and prolonged retention through the bladder wall and regional lymphoid nodes. 24 Encouraging results in muscle invasive urothelial cancer can open the doors for bladder preservation in bladder cancer.…”

Section: Therapeutic Applicationsmentioning

confidence: 99%

Current status of nanotechnology in urology

2016

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“…Intravesical chemotherapy is a mainstay in treatment of localised TCC of the bladder. A Japanese study investigated the distribution of doxorubicin within the bladder wall and regional lymph nodes after intravesical instillation . In this in vivo canine study, one treatment group received free doxorubicin administered i.v., while the other treatment group underwent intravesical submucosal injection of liposome‐encapsulated doxorubicin.…”

Section: Drug Deliverymentioning

confidence: 99%

Nanotechnology applications in urology: a review

et al. 2014

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The objectives of this review are to discuss the current literature and summarise some of the promising areas with which nanotechnology may improve urological care. A Medline literature search was performed to elucidate all relevant studies of nanotechnology with specific attention to its application in urology. Urological applications of nanotechnology include its use in medical imaging, gene therapy, drug delivery, and photothermal ablation of tumours. In vitro and animal studies have shown initial encouraging results. Further study of nanotechnology for urological applications is warranted to bridge the gap between preclinical studies and translation into clinical practice, but nanomedicine has shown significant potential to improve urological patient care.

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Distribution of Doxorubicin in the Bladder Wall and Regional Lymph Nodes After Bladder Submucosal Injection of Liposomal Doxorubicin in the Dog

Abstract: The present results demonstrate that Lip-Dox injected into the bladder submucosally distributes well, both in the whole bladder wall and in regional lymph nodes and remains at a high concentration in these tissues for at least one week after injection.

Cited by 3 publications

References 12 publications

Effect of small-sized liposomal Adriamycin administered by various routes on a metastatic breast cancer model

Effect of small-sized liposomal Adriamycin administered by various routes on a metastatic breast cancer model

Current status of nanotechnology in urology

Nanotechnology applications in urology: a review

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