Effect of small-sized liposomal Adriamycin administered by various routes on a metastatic breast cancer model

Abstract

The antitumor effects of small-sized liposomal Adriamycin (LADR) administered by various routes were investigated in rabbits bearing well-developed VX2 tumors in the mammary gland. Rabbits received s.c. or i.v., or s.c. combined with i.v., injections of LADR 6 weeks after tumor implantation. The i.v. route showed a significant inhibitory effect on breast tumors and distant metastases. In comparison, metastases in axillary and mediastinal lymph nodes were more efficiently inhibited after s.c. injection. LADR administered concurrently by both the i.v. and s.c. routes produced satisfactory therapeutic activities on both primary breast tumors and metastases in local-regional lymph nodes, lungs and liver, as shown by slowed growth rates, decreased mRNA expression of proliferating cell nuclear antigen, and extensive necrosis and apoptosis of tumor cells. It is concluded that smallsized LADR administered s.c. provides reliable efficacy on lymphatic metastases of breast cancer and that the addition of treatment by the s.c. route to that by the conventional i.v. route can be recommended as a promising procedure to enhance chemotherapeutic effects in patients with metastatic breast cancer.

In Vitro Evaluation of the Efficacy of Liposomal and Pegylated Liposomal Hydroxyurea

“…In addition a similar study by Chen et al [24] indicated that Adriamycin in liposomal form targeted diffuse breast cancer cells, however, not only massive amounts of Liposomes were absorbed by tumor cells, but also the rate of cellular toxicity was significantly increased. Interestingly, any type of allergic reaction or toxicity was not observed by the investigators in patients.…”

Co-Encapsulation of Doxorubicin With Galactoxyloglucan Nanoparticles for Intracellular Tumor-Targeted Delivery in Murine Ascites and Solid Tumors

“…But, the most common side-effects associated with anthracycline analogues like Dox include acute and chronic toxicities such as myelosuppression, cardiomyopathies and congestive cardiac failure [3], [4]. To overcome these side-effects, integrated approaches utilizing combination therapies with cytotoxic, chemosensitizing and nanoparticle agents have been devised.…”

Methoxy Poly(ethylene glycol)-Poly(lactide) Nanoparticles Encapsulating Quercetin Act as an Effective Anticancer Agent by Inducing Apoptosis in Breast Cancer

“…The systemic toxicity and reduced incursion of chemotherapeutic drugs into breast tissue is leading into constant demands for developing new therapeutic agents capable of eliminating these problems and are clinically applicable against breast cancer [28]. Plants are known to possess pharmacological diversified properties and are rich source of clinically important phytochemicals against various diseases, including cancer.…”