Socially shared representations of history have been important in creating, maintaining and changing a people's identity. Their management and negotiation are central to interethnic and international relations. We present a narrative framework to represent how collectively significant events become (selectively) incorporated in social representations that enable positioning of ethnic, national and supranational identities. This perspective creates diachronic (temporal) links between the functional (e.g. realistic conflict theory), social identity, and cognitive perspectives on intergroup relations. The charters embedded in these representations condition nations with similar interests to adopt different political stances in dealing with current events, and can influence the perceived stability and legitimacy of social orders. They are also instrumental in determining social identity strategies for reacting to negative social comparisons, and can influence the relationships between national and ethnic identities.

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Three studies examine the psychometric properties (i.e., the test-retest reliability, convergent, and discriminant validity) of Fraley, Waller, and Brennan's Revised Experiences in Close Relationships (ECR-R) self-report measure of romantic attachment anxiety (model of self) and avoidance (model of others). Longitudinal analyses suggest that the ECR-R provided highly stable indicators of latent attachment during a 3-week period (85% shared variance). Hierarchical linear modeling analyses further validated the ECR-R, suggesting that it explained between 30% to 40% of the between-person variation in social interaction diary ratings of attachment-related emotions experienced during interactions with a romantic partner and only 5% to 15% of that in interactions with family and friends. Guidelines are offered regarding the conditions where highly reliable and precise measures of romantic attachment, such as the ECR-R, are deemed necessary and where shorter, albeit slightly less reliable measures, such as Bartholomew and Horowitz's Relationship Questionnaire, may also be viable.

Background MicroRNAs are small (18–22 nucleotides) noncoding RNAs involved in posttranscriptional modification of many target genes. One of these, microRNA-21 (miR-21), has been shown to play a role in multiple hematologic and solid organ malignancies. We sought to determine the expression pattern of miR-21 in pancreatic cancers and its impact on clinicopathologic characteristics. Methods Eighty resected pancreatic cancer specimens were microdissected and tissue microarrays (TMA) created in duplicate. TMAs were also created for benign pancreas (N=12) and chronic pancreatitis (N=45). In situ hybridization (ISH) was undertaken utilizing locked nucleic acid probes for miR-21. RNA U6 and scrambled RNA served as positive and negative control, respectively. ISH was scored as 0 (absent), 1+ (faint/focal expression), or 2+ (strong expression). Kaplan– Meier survival curves were constructed and compared by log-rank analysis. Results MiR-21 expression was demonstrated in 63 (79%) pancreatic cancers (1+ in 49, 2+ in 14) compared to one of 12 (8%, p<0.0001) benign pancreas and 12/45 (27%, p<0.0001) chronic pancreatitis. None of the benign tissues demonstrated strong miR-21 expression. Although miR-21 expression did not correlate with tumor size, differentiation, nodal status, or T stage, strong miR-21 expression was predictive of poorer outcome compared to absent or faint/focal miR-21 expression in patients with node-negative disease (median 27.7 months vs. 15.2, p=0.037). Nodal status was also predictive of survival (p=0.029). Conclusions MicroRNA-21 is significantly overexpressed in pancreatic cancers as detected by in situ hybridization. Its strong expression predicts limited survival in patients with node-negative disease and may be an important biologic marker for outcome.

OR YEARS, THERE HAS BEEN CONcern about possible associations of gynecologic malignancies with postmenopausal hormone therapy. The development of endometrial hyperplasia and endometrial cancer with unopposed estrogen is well recognized. To reduce or avoid this complication, progestin has been added, 1-3 although results from randomized trials are extremely limited. These concerns have created a need for reasonable monitoring guidelines to follow-up women who experience vaginal bleeding while taking estrogen plus progestin. The Women's Health Initiative (WHI) trial of estrogen plus progestin provides the first opportunity to examine possible associations of gynecologic malignancies with continuous combined postmenopausal hormone therapy in a large, randomized, double-blind, placebo-controlled setting. The trial was stopped early at the recommendation of the independent data and safety monitoring board on the basis of an increased risk of breast cancer supported by a summary measure of effects indicating risks exceeded

During the SARS-CoV-2 pandemic, novel and traditional vaccine strategies have been deployed globally. We investigated whether antibodies stimulated by mRNA vaccination (BNT162b2), including 3 rd dose boosting, differ from those generated by infection or adenoviral (ChAdOx1-S and Gam-COVID-Vac) or inactivated viral (BBIBP-CorV) vaccines. We analyzed human lymph nodes after infection or mRNA vaccination for correlates of serological differences. Antibody breadth against viral variants is less after infection compared to all vaccines evaluated, but improves over several months. Viral variant infection elicits variant-specific antibodies, but prior mRNA vaccination imprints serological responses toward Wuhan-Hu-1 rather than variant antigens. In contrast to disrupted germinal centers (GCs) in lymph nodes during infection, mRNA vaccination stimulates robust GCs containing vaccine mRNA and spike antigen up to 8 weeks post-vaccination in some cases. SARS-CoV-2 antibody specificity, breadth and maturation are affected by imprinting from exposure history, and distinct histological and antigenic contexts in infection compared to vaccination.

Membership in important social groups can promote a positive identity. We propose and test an identity resource model in which personal self-esteem is boosted by membership in additional important social groups. Belonging to multiple important group memberships predicts personal self-esteem in children (Study 1a), older adults (Study 1b), and former residents of a homeless shelter (Study 1c). Study 2 shows that the effects of multiple important group memberships on personal self-esteem are not reducible to number of interpersonal ties. Studies 3a and 3b provide longitudinal evidence that multiple important group memberships predict personal self-esteem over time. Studies 4 and 5 show that collective self-esteem mediates this effect, suggesting that membership in multiple important groups boosts personal self-esteem because people take pride in, and derive meaning from, important group memberships. Discussion focuses on when and why important group memberships act as a social resource that fuels personal self-esteem.

This study explored differences in levels of anti‐egalitarianism and social dominance orientation among groups with different social status, and examined the degree to which these differences in anti‐egalitarianism varied across a number of situational and contextual factors. Consistent with both the cultural deterministic (CD) and social dominance (SD) paradigms, when defining social status as socioeconomic status, ethnicity, or ‘race’, differences in anti‐egalitarianism between members of high‐ and low‐status groups were found to be contingent upon a range of contextual and situational factors, such as the degree to which the two groups varied in social status. However, consistent with the SD perspective and the invariance hypothesis, the data also showed that males were more anti‐egalitarian than females, and that this male/female difference in social and group dominance orientation tended to be largely invariant across cultural, situational, and contextual boundaries. Copyright © 2000 John Wiley & Sons, Ltd.