Distribution characteristics of methamphetamine and amphetamine in urine and hair specimens collected from alleged methamphetamine users in northern Taiwan

Wang, Sheng-Meng; Lin, Chen-Si; Li, Tien-Lai; Shih, Chun-Yao; Giang, Yun-Seng; Liu, Ray H.

doi:10.1016/j.aca.2006.01.007

Cited by 11 publications

(5 citation statements)

References 33 publications

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“…Carryover was evaluated by injecting an InStd‐fortified blank urine sample immediately after injecting a sample fortified with 5000 ng/mL of the entire set of the target analytes or 50,000 ng/mL of MA. A high MA concentration (approximately 40 000 ng/mL) in authentic urine samples was reported by a previous study . The carryover rate was calculated using the measured concentration of the blank sample.…”

Section: Methodsmentioning

confidence: 90%

See 1 more Smart Citation

Improved identification of multiple drugs of abuse and relative metabolites in urine samples using liquid chromatography/triple quadrupole mass spectrometry coupled with a library search

Lin

Liao

Lin

2014

Rapid Commun. Mass Spectrom.

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Section: Methodsmentioning

confidence: 90%

“…A high MA concentration (approximately 40 000 ng/mL) in authentic urine samples was reported by a previous study. [21] The carryover rate was calculated using the measured concentration of the blank sample. If the measured concentration was below LOD, then carryover was considered negligible.…”

Section: Methods Validationmentioning

confidence: 99%

Improved identification of multiple drugs of abuse and relative metabolites in urine samples using liquid chromatography/triple quadrupole mass spectrometry coupled with a library search

Lin

Liao

Lin

2014

Rapid Commun. Mass Spectrom.

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“…Hair analysis is typically employed for the assessment of repeated or chronic exposure to drugs in different settings 1011 . In postmortem toxicology, hair analysis may be useful for the assessment of naïve 12 or chronic 13 MAMP intake, in order to evaluate a subject’s tolerance.…”

Section: Discussionmentioning

confidence: 99%

Incorporation of methamphetamine and amphetamine in human hair following controlled oral methamphetamine administration

Polettini

Cone²,

Gorelick

et al. 2012

Analytica Chimica Acta

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Background Although hair testing is well established for the assessment of past drug exposure, uncertainties persist about mechanisms of drug incorporation into hair and interpretation of results. The aim of this study was to administer methamphetamine (MAMP) under controlled conditions as a model drug to investigate drug incorporation into human hair. Material and Methods Seven volunteers with a history of stimulant use received 4×10 mg (low) doses of sustained release S-(+)-MAMP HCl within one week, with weekly head hair samples collected by shaving. 3 weeks later, 4 of them received 4×20 mg (high) doses. After extensive isopropanol/phosphate buffer washing of the hair, MAMP and its metabolite amphetamine (AMP) concentrations were determined in all weekly hair samples by LC-MS-MS in selected reaction monitoring mode with the undeca- and deca-deuterated drugs, respectively, as internal standards (LLOQ, 0.005 ng/mg). Results MAMP Tmax occurred from 1 to 2 weeks after both doses, with Cmax ranging from 0.6–3.5 ng/mg after the low and 1.2–5.3 ng/mg after the high MAMP doses. AMP Cmax in hair was 0.1–0.3 ng/mg and 0.2–0.5 ng/mg, respectively, for low and high doses. Highly dose–related concentrations within subjects, but large variability between subjects were observed. MAMP concentrations were above the 0.2 ng/mg cutoff for at least two weeks following administration of both low and high doses. The overall AMP/MAMP ratio ranged from 0.07 to 0.37 with a mean value of 0.15±0.07, and a median of 0.13. The percentage of MAMP and AMP removed with the washing procedure decreased with time after administration. A strong correlation was found between area under the curve of MAMP (r2=0.90, p=0.00) and AMP (r2=0.94, p=0.00) concentrations calculated for the 3-week period following administration and the total melanin concentration in hair. Significant correlations were observed also between Cmax and melanin. Conclusions This study demonstrated that despite large inter-individual differences, the incorporation of MAMP and AMP into hair is dose-related with much of the observed scatter of MAMP and AMP concentrations explained by melanin concentration in hair.

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“…MA has been detected in hair under various extraction methods such as LLE [2,[28][29][30], SPE [31][32][33] or SPME [34] and derivatization such as TFAA [23][24][25]35,36], HFBA [31,37] or PFPA [30] and detection methods such as GC/MS [1,2,[30][31][32][33][34][35][36][37], HPLC [38,39] and LC-MS/MS [28,36,39,40]. However, the relationship between 1 cm-segmental hair analysis results and drug consumption habits has rarely been reported in the literature [1,34,37].…”

Section: Consistency Between History Of Ma Use and Ma Concentrations mentioning

confidence: 99%

Hair analysis and self-report of methamphetamine use by methamphetamine dependent individuals

Han

Paulus

Wittmann

et al. 2011

Journal of Chromatography B

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Distribution characteristics of methamphetamine and amphetamine in urine and hair specimens collected from alleged methamphetamine users in northern Taiwan

Cited by 11 publications

References 33 publications

Improved identification of multiple drugs of abuse and relative metabolites in urine samples using liquid chromatography/triple quadrupole mass spectrometry coupled with a library search

Improved identification of multiple drugs of abuse and relative metabolites in urine samples using liquid chromatography/triple quadrupole mass spectrometry coupled with a library search

Incorporation of methamphetamine and amphetamine in human hair following controlled oral methamphetamine administration

Hair analysis and self-report of methamphetamine use by methamphetamine dependent individuals

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