Hair analysis and self-report of methamphetamine use by methamphetamine dependent individuals

Han, Eunyoung; Paulus, Martin P.; Wittmann, Marc; Chung, Heesun; Song, Joon Myong

doi:10.1016/j.jchromb.2011.01.002

Cited by 38 publications

(34 citation statements)

References 58 publications

(89 reference statements)

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“…The levels reported were similar to those reported in studies conducted on low-level methamphetamine use by adults smoking doses of approximately 500-1,000 mg/day (8). The detection of amphetamine in the hair of the younger children might reflect environmental exposures in the home, where low levels of amphetamine also were detected in the surface samples analyzed (but not quantified by the laboratory), or the presence of metabolites, supporting the systemic absorption of methamphetamine.…”

Section: Discussionsupporting

confidence: 80%

“…Methamphetamine levels in the hair samples of the two younger children (460 pg/mg and 330 pg/mg) are consistent with the lower end of the range reported in children removed from clandestine drug laboratories (range = 100 pg/mg-131,000 pg/mg) (6,7) and chronic adult drug users (range = 100 pg/mg-128,000 pg/mg) (6,8). The levels reported were similar to those reported in studies conducted on low-level methamphetamine use by adults smoking doses of approximately 500-1,000 mg/day (8).…”

Section: Discussionsupporting

confidence: 77%

“…First, there is no established quantitative relationship between the dose of methamphetamine to which a person is exposed and the measured methamphetamine level in hair. In addition, there is significant variation among persons who might have had the same level of exposure and the measured levels in hair, although for an individual, correlation between dose and the concentration of amphetamines in hair has been reported (8,10). However, the data reported for the family members support the association of higher levels of methamphetamine and amphetamine in hair with higher levels of exposure (based on reported activities, body weight, and time in the contaminated home).…”

Section: Discussionmentioning

confidence: 96%

See 2 more Smart Citations

Adverse Health Effects Associated with Living in a Former Methamphetamine Drug Laboratory — Victoria, Australia, 2015

Wright¹,

Kenneally²,

Edwards³

et al. 2017

MMWR Morb. Mortal. Wkly. Rep.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Adverse Health Effects Associated with Living in a Former Methamphetamine Drug Laboratory — Victoria, Australia, 2015

Wright¹,

Kenneally²,

Edwards³

et al. 2017

MMWR Morb. Mortal. Wkly. Rep.

View full text Add to dashboard Cite

“…A positive linear relationship between dose and hair concentration has been identified for cocaine and medicinal drug use (200) with segmented analysis of hair used to evaluate changes in dose over time (201,202). In relation to use of methamphetamine, a positive dose-response relationship has been demonstrated with rat hair (203), in drug users (204) and in a controlled study (199).…”

Section: Dose Responsementioning

confidence: 93%

Exposures associated with clandestine methamphetamine drug laboratories in Australia

Wright

Edwards

Walker

2016

Reviews on Environmental Health

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AbstractThe clandestine manufacture of methamphetamine in residential homes may represent significant hazards and exposures not only to those involved in the manufacture of the drugs but also to others living in the home (including children), neighbours and first responders to the premises. These hazards are associated with the nature and improper storage and use of precursor chemicals, intermediate chemicals and wastes, gases and methamphetamine residues generated during manufacture and the drugs themselves. Many of these compounds are persistent and result in exposures inside a home not only during manufacture but after the laboratory has been seized or removed. Hence new occupants of buildings formerly used to manufacture methamphetamine may be unknowingly exposed to these hazards. Children are most susceptible to these hazards and evidence is available in the literature to indicate that these exposures may result in immediate and long-term adverse health effects. The assessment of exposure within the home can be undertaken by measuring contaminant levels or collecting appropriate biological data from individuals exposed. To gain a better understanding of the available data and key issues associated with these approaches to the characterisation of exposure, a review of the published literature has been undertaken.

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“…Nevertheless, the protocol's AM LOD would have failed to corroborate a majority of MA positives. Further, this protocol's AM LOQ would have been sensitive enough to provide data for the calculation of only a small percentage of AM/MA ratios, which can be a useful diagnostic tool for interpreting original MA dosages, the possibility of sample contamination, and the independent use of AM [30][31][32].…”

Section: Methodsmentioning

confidence: 99%

Validation and application of hair analysis for the detection of methamphetamine in young Thai adults

et al. 2014

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Background:To date, blood and urine analyses have been the major methods of detecting methamphetamine (MA) use in Thailand. Recently, hair analysis has been introduced as an alternative and complementary procedure. Objectives: To validate a simple, rapid, and economical method of analyzing hair for MA and its metabolite, amphetamine (AM). Methods: The analysis employed solid-phase microextraction (SPME) coupled with gas chromatography and mass spectrometry (GC-MS). Simplicity, rapidity, and economy were achieved, in part, by optimizing SPME conditions and by eliminating deuterated reagents and the derivatization step in GC-MS. The validated method was employed to detect and quantify MA in 1,111 hair samples of young Thai research volunteers who reported using MA in the form of so-called "yaba" tablets at least 3 times during the previous 3 months. Results: Validated data from the study indicated that the method's linearity, accuracy, precision, limit of detection (LOD) and limit of quantitation (LOQ) met international standards for hair analysis of MA. Expressed as ng of MA per mg of hair (ng/mg), the LOQ was 0.5 ng/mg (102.39% accuracy, 5.46% precision). The method was less sensitive for quantification of AM in hair, with a LOQ of 2.5 ng/mg (103.41% accuracy, 6.95% precision). Using 0.5 ng/mg as a cutoff in the analysis of samples provided by admitted MA users, the study yielded an overall detection rate for MA of 35.5%, with a range of 0.51-54.61 ng/mg; the mean MA level was 4.90 ± 6.78 (±SD) ng/mg. Thirty-one percent of the participants reported they had consumed fewer than 10 yaba tablets during the previous 3 months. Of this group, 29% had hair samples that tested positive for MA. Detection rates trended upwards with increased yaba use. No relationship was found between the number of yaba tablets reportedly consumed and the concentration of MA detected in hair. Conclusions: This study validated a rapid, simple, and economical SPME/GC-MS technique for quantification of MA in hair. The method was less sensitive for quantification of AM.

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Hair analysis and self-report of methamphetamine use by methamphetamine dependent individuals

Cited by 38 publications

References 58 publications

Adverse Health Effects Associated with Living in a Former Methamphetamine Drug Laboratory — Victoria, Australia, 2015

Adverse Health Effects Associated with Living in a Former Methamphetamine Drug Laboratory — Victoria, Australia, 2015

Exposures associated with clandestine methamphetamine drug laboratories in Australia

Validation and application of hair analysis for the detection of methamphetamine in young Thai adults

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