Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese

Cao, Pingping; Li, Hua-Bin; Wang, Baofeng; Wang, Shuibin; You, Xueji; Cui, Yunan; Wang, Deyun; Desrosiers, Martin; Liu, Zheng

doi:10.1016/j.jaci.2009.05.017

Cited by 528 publications

(833 citation statements)

References 27 publications

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“…This was further supported by immunohistochemical analysis, which showed an increased accumulation of CD3 ϩ (p Ͻ 0.01), CD4 ϩ , and CD8 ϩ cells in the CRSwNP subjects. This is in accordance with earlier studies 6,18,20 and indicates a higher degree of inflammatory cell infiltration in CRSwNP.…”

Section: Discussionsupporting

confidence: 94%

“…Of these, CRSwNPs, the most commonly studied type of CRS, appears to be primarily a T H 2 response with an accumulation of eosinophils, T cells, neutrophils, and plasma cells associated with elevated levels of IL-5 and IgE and decreased levels of transforming growth factor (TGF) ␤1. 2,[4][5][6] In contrast, CRSsNPs is characterized by a predominant T H 1 milieu with increased interferon (IFN) ␥ and TGF-␤1 levels. 4,6 However, some data suggest a mix of both T H 1 and T H 2 inflammation with a predominance of one type in both forms of the disease-with and without polyposis.…”

Section: Hronic Rhinosinusitis (Crs) Is a Mucosal Inflammatory Disementioning

confidence: 99%

“…2,[4][5][6] In contrast, CRSsNPs is characterized by a predominant T H 1 milieu with increased interferon (IFN) ␥ and TGF-␤1 levels. 4,6 However, some data suggest a mix of both T H 1 and T H 2 inflammation with a predominance of one type in both forms of the disease-with and without polyposis. 7,8 To date, the pathogenesis of CRS has not been fully elucidated, and few studies provide insights about dysregulated T H 1/T H 2 mucosal immunity that characterize this disorder.…”

Section: Hronic Rhinosinusitis (Crs) Is a Mucosal Inflammatory Disementioning

confidence: 99%

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Peripheral Blood and Tissue T Regulatory Cells in Chronic Rhinosinusitis

Sharma

Watanabe

Sivam

et al. 2012

Am J Rhinol�Allergy

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Section: Discussionsupporting

confidence: 94%

Section: Hronic Rhinosinusitis (Crs) Is a Mucosal Inflammatory Disementioning

confidence: 99%

Section: Hronic Rhinosinusitis (Crs) Is a Mucosal Inflammatory Disementioning

confidence: 99%

See 1 more Smart Citation

Peripheral Blood and Tissue T Regulatory Cells in Chronic Rhinosinusitis

Sharma

Watanabe

Sivam

et al. 2012

Am J Rhinol�Allergy

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“…This suggests that non-eosinophilic inflammation plays an important role in CRSwNP in Chinese patients, which is in agreement with the findings of previous research (30,31). In the current study, the supernatant ECP and MPO levels were elevated in the eosinophilic CRSwNP groups.…”

supporting

confidence: 93%

Different roles of Staphylococcus aureus enterotoxin in different subtypes of nasal polyps

Cheng

Wang

2016

Experimental and Therapeutic Medicine

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Abstract. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disease. The pathogenesis of CRSwNP remains unclear. This study was designed to investigate the role of inflammation and Staphylococcus aureus enterotoxin (SE) in this disease. The study included a total of 74 patients with CRSwNP and 6 controls. A serum Phadiatop assay was conducted to detect atopy status, and serum eosinophil cationic protein (ECP) and total immunoglobulin (Ig)E levels were determined using ELISA. SEA, SEB, total IgE, ECP and myeloperoxidase (MPO) levels in nasal tissue supernatant were measured using ELISA. The results indicated that 15 (22.1%) patients had systemic allergies. On the basis of the ECP/MPO ratio, the patients were divided into an eosinophilic CRSwNP group (n=18) and a non-eosinophilic CRSwNP group (n=56). The total ECP/MPO ratio was 0.572, with a notable bias toward neutrophilic inflammation. The supernatant ECP and MPO levels were elevated in the CRSwNP group compared with the control group, but no significant difference in the serum total IgE and ECP levels were observed between the CRSwNP and control groups. In addition, the non-eosinophilic and eosinophilic CRSwNP groups showed significant elevations in supernatant total IgE, SEA and SEB levels compared with the control group. Thus, it may be concluded that allergy is a common pathogenesis of CRSwNP, and neutrophilic inflammation is present in most Chinese CRSwNP patients. Additionally, local indicators reflect the inflammatory status more accurately than do serum indicators. SEs may act as an infection factor rather than as a superantigen in Chinese non-eosinophilic CRSwNP patients. Thus, long-term antibiotic therapy may be an option for Chinese non-eosinophilic CRSwNP patients.

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“…CRS is characterized by persistent inflammation of the nasal and paranasal sinus mucosa. CRS without nasal polyps represented a predominant neutrophilic inflammation and TH1 milieu in the stroma (12). While factors affecting the chronic inflammation and edema development in CRS are not clearly revealed, cytokines like IL-1α, IL-1β, IL-6, interferon-α, TNF, and IL-8 have been reported to have important roles in the inflammatory response (13).…”

Section: Discussionmentioning

confidence: 99%

Mean Platelet Volume as an Inflammatory Marker in Chronic Sinusitis

2011

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Aim: Chronic rhinosinusitis (CRS) is characterized by persistent inflammation of the nasal and paranasal sinus mucosa. The pathogenesis of chronic sinusitis is not yet clearly understood. Recently, mean platelet volume (MPV) has been known as a simple inflammatory marker in inflammatory diseases. The aim of this study was to investigate the levels of hematological parameters such as red blood cells (RBC), haemoglobine (Hb), haematocrit (Htc), white blood cells (WBC), platelet (PLT), and mean platelet volume (MPV) in patients with CRS without nasal polyposis. Method

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Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese

Cited by 528 publications

References 27 publications

Peripheral Blood and Tissue T Regulatory Cells in Chronic Rhinosinusitis

Peripheral Blood and Tissue T Regulatory Cells in Chronic Rhinosinusitis

Different roles of Staphylococcus aureus enterotoxin in different subtypes of nasal polyps

Mean Platelet Volume as an Inflammatory Marker in Chronic Sinusitis

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