Mean Platelet Volume as an Inflammatory Marker in Chronic Sinusitis

Koç, Sema; Eyibilen, Ahmet; Erdoğan, Ahmet Serhat

doi:10.29333/ejgm/82761

Cited by 6 publications

(5 citation statements)

References 17 publications

(8 reference statements)

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“…In chronic sinusitis, as reported by Koç et al [11], the platelet count is at the upper normal limit as compared to healthy subjects. Also, MPV is significantly higher in this group of patients.…”

Section: Mpv In Inflammationmentioning

confidence: 78%

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Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions

Korniluk

Koper-Lenkiewicz

Kamińska

et al. 2019

Mediators of Inflammation

385

350

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Platelet size has been demonstrated to reflect platelet activity and seems to be a useful predictive and prognostic biomarker of cardiovascular events. It is associated with a variety of prothrombotic and proinflammatory diseases. The aim is a review of literature reports concerning changes in the mean platelet volume (MPV) and its possible role as a biomarker in inflammatory processes and neoplastic diseases. PubMed database was searched for sources using the following keywords: platelet activation, platelet count, mean platelet volume and: inflammation, cancer/tumor, cardiovascular diseases, myocardial infarction, diabetes, lupus disease, rheumatoid arthritis, tuberculosis, ulcerative colitis, renal disease, pulmonary disease, influencing factors, age, gender, genetic factors, oral contraceptives, smoking, lifestyle, methods, standardization, and hematological analyzer. Preference was given to the sources which were published within the past 20 years. Increased MPV was observed in cardiovascular diseases, cerebral stroke, respiratory diseases, chronic renal failure, intestine diseases, rheumatoid diseases, diabetes, and various cancers. Decreased MPV was noted in tuberculosis during disease exacerbation, ulcerative colitis, SLE in adult, and different neoplastic diseases. The study of MPV can provide important information on the course and prognosis in many inflammatory conditions. Therefore, from the clinical point of view, it would be interesting to establish an MPV cut-off value indicating the intensity of inflammatory process, presence of the disease, increased risk of disease development, increased risk of thrombotic complications, increased risk of death, and patient’s response on applied treatment. Nevertheless, this aspect of MPV evaluation allowing its use in clinical practice is limited and requires further studies.

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Section: Mpv In Inflammationmentioning

confidence: 78%

“…Also, MPV is significantly higher in this group of patients. This may suggest the involvement of blood platelets in the development and course of the disease [11].…”

Section: Mpv In Inflammationmentioning

confidence: 99%

Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions

Korniluk

Koper-Lenkiewicz

Kamińska

et al. 2019

Mediators of Inflammation

385

350

View full text Add to dashboard Cite

show abstract

“…[11] Koç et al demonstrated that MPV level was significantly higher in Chronic recurrent sinusitis compared to control group and PLT level was borderline higher in CRS group compared to control group. [12] S.Bozkur et al showed that there was no statistically significant difference between patients with appendicitis (complicated or uncomplicated) and those having no appendicitis with respect to MPV level. However, the complicated appendicitis group had a lower MPV value compared to other groups.…”

Section: Discussionmentioning

confidence: 99%

Role of Mean platelet Volume as an adjunct in evaluation of acute inflammation

Afsar

Afroze

Tahniath

et al. 2017

APALM

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Background: Platelets are also known for their role in the pathophysiology of vascular inflammation. Activated platelets can promote vascular inflammation, causing endothelial inflammation and subsequent leucocyte extravasation. Increased MPV may be used as a marker of platelet activation. We aim to study the relationship of MPV with total WBC count in cases with neutrophilic leucocytosis and to assess if MPV may have any role as an inflammatory marker. Methods:A retrospective study was conducted including 97 cases of leucocytosis with neutrophilia. 95 age and sex matched healthy individuals were used as controls. MPV values and total WBC counts were obtained on automated cell counter Horiba pentra ES60 and manual differential count was performed.Results: MPV did not show any significant change in the study group compared to the control group. MPV was noted to be higher in cases with associated thrombocytopenia, while MPV was lower in cases with thrombocytosis. Conclusion:MPV has no direct role in the evaluation of acute inflammation. However the increased MPV noted in cases of thrombocytopenia with neutrophilic leucocytosis suggests that activation of platelets causes a rise in MPV due to shape change and may be implicated in impending sepsis and disseminated intravascular coagulation due to the production of thromboxane A2 by activated platelets, warranting the need for further workup and prospective studies in order to establish the role of MPV as a marker for impending sepsis and DIC in cases with neutrophilic leucocytosis.

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“…Elevated MPV values have been attributed to emotional stress [ 40 ], increased sympathetic activity in patients with depression [ 17 , 38 , 41 , 42 ], and in patients with generalized anxiety disorder [ 35 ]. More recently, changes in platelet parameters have been linked to inflammatory processes, thus an abnormal MPV might indicate inflammation in psychiatric conditions [ 43 , 44 ]. However, the exact mechanism behind the association of changes in platelet parameters and affective disorders is not yet clearly established, since there have been results showing significantly decreased MPV in major depression [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Depression and Anxiety Symptoms Are Associated with Mean Platelet Volume in Autoimmune Disorders

Fábián

Horváth

Shemirani

et al. 2022

IJERPH

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Platelets are increasingly considered a bridge between mental and immunological disorders. However, data relating to platelet parameters in patients with autoimmune disorders are limited. The aim of the present study was to investigate, for the first time, the association of platelet parameters with the symptoms of affective disorders in patients with autoimmune conditions. In this cross-sectional study, we measured the complete blood count (CBC), the Generalized Anxiety Disorder Scale for anxiety (GAD-7), and the Beck Depression Inventory for depression (BDI) in 121 patients with autoimmune disorders. Mean platelet volume (MPV) was positively correlated with both anxiety and depression. Platelet distribution width (PDW) was negatively correlated with anxiety and depression. Before adjustment for covariates, logistic regression analysis revealed a significant association of MPV with depression and anxiety. After adjustment for covariates, only depression was associated with MPV. The area under the ROC curve of MPV for GAD-7 determined anxiety and BDI determined depression was 0.63. Our study showed that among the CBC hematological parameters, the MPV might be a useful biomarker of depression and anxiety in patients with autoimmune disorders. Further investigations of platelet parameters in controlled prospective studies are warranted to confirm our preliminary results.

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Mean Platelet Volume as an Inflammatory Marker in Chronic Sinusitis

Cited by 6 publications

References 17 publications

Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions

Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions

Role of Mean platelet Volume as an adjunct in evaluation of acute inflammation

Depression and Anxiety Symptoms Are Associated with Mean Platelet Volume in Autoimmune Disorders

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