Dissolving microneedles for effective and painless intradermal drug delivery in various skin conditions: A systematic review

Abstract

Intra-and transdermal drug delivery via the skin offers a non-to minimally-invasive, effective, and patient-compliant method for administrating substances such as medication or vaccines. 1-3 Intra-and transdermal delivery is considered profoundly safe, maintains a steady plasma concentration and avoids the significant hepatic first-pass metabolism effect which limits the biological availability in enteral administration. [1][2][3][4] Parenteral administration via cutaneous penetration is considered to be painful and when done frequently harbors the risk of infection, is inconvenient, and reduces patient compliance. 2,5,6 Topical

Photo-crosslinkable polyester microneedles as sustained drug release systems toward hypertrophic scar treatment

“…In our previous study, De Decker et al. successfully applied 0.89 mg/cm 2 corticosteroid-loaded hyaluronic acid patches on hypertrophic wounds in a 4-month pilot study (De Decker et al., 2023c ). However, the HA-based MN arrays applied in the pilot study consisted of 320 MNs, whereas the currently developed MN arrays consisted of 36 individual MNs.…”

“…To determine the mechanical properties, compression testing was performed on a universal testing machine (Tinius Olsen) equipped with a 25 N load cell at room temperature (De Decker et al., 2023c ). The preload was set at 0.1 N, and the speed of the compression was set at 0.5 mm/min until 20 N load was reached.…”

“…They offer direct drug delivery to the dermis, therefore, enhancing transdermal delivery efficiency of therapeutical drugs, while preventing the stimulation of pain receptors (Tan et al., n.d ; Lin et al., 2019 ; Du and Sun, 2020 ; Bhadale and Londhe, 2021 ). To date, several MN alternatives are available, namely solid, dissolvable, hollow, coated and hydrogel microneedles (Nagarkar et al., 2020 ; Aldawood et al., 2021 ; De Decker et al., 2023c ; Koyani, 2020 ; Prausnitz, 2004 ). They provide various drug delivery mechanisms and efficiencies in line with their applications.…”

“…They successfully maintained a faster and improved healing profile on HTS during 4 months of therapy, involving 4 MN-insertion treatments. The applied HA-based MN arrays were correlating with a drug load of 0.89 mg/cm 2 , and the active compound was intradermally delivered within 30 minutes following insertion of the arrays (De Decker et al., 2023c ).…”

New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

“…By momentarily disturbing the skin’s surface layer, the microneedle delivery device uses the diffusion process to transfer the medicine through the skin. On a tiny patch, hundreds of microneedles are organized to help distribute enough medication to have a therapeutic impact. , The trilayer dissolving microneedle array (RBTF-TDMNs) was created to maximize the intradermal administration of RBTF for the treatment of melanoma. It has been demonstrated that RBTF-TDMNs are powerful enough to penetrate excised porcine skin while keeping their physicochemical qualities, quickly disintegrate, and deposit RBTF intradermally.…”