Intra-and transdermal drug delivery via the skin offers a non-to minimally-invasive, effective, and patient-compliant method for administrating substances such as medication or vaccines. 1-3 Intra-and transdermal delivery is considered profoundly safe, maintains a steady plasma concentration and avoids the significant hepatic first-pass metabolism effect which limits the biological availability in enteral administration. [1][2][3][4] Parenteral administration via cutaneous penetration is considered to be painful and when done frequently harbors the risk of infection, is inconvenient, and reduces patient compliance. 2,5,6 Topical