Diseases Prevention by Water Defluoridation Using Hydrotalcites as Decontaminant Materials

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The usual treatment for tuberculosis is difficult by its long-term therapy, raised dosing frequency and adverse effects of anti-tuberculosis drugs. Anionic clays, also called layered double hydroxides are a class of hydrotalcite like structures having high compositional variety and being able to self-assembly in the presence of drug molecules. The work refers to the development of nanohybrid materials like delivery systems that intercalates isonicotinic acid hydrazide, known as isoniazid anti-tuberculosis drug, into layered structure of hydrotalcite compounds. Loaded drug molecules of isoniazid were proved to be released in a controlled way from the as synthesized nanostructure in a simulated buffer solution. The obtained sample was characterized by advanced techniques thus demonstrating the inclusion of isoniazid antibiotic between hydrotalcite sheets. These results revealed important expectations for further researches of these organic-inorganic nanocomposites for tuberculosis treatment.

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confidence: 99%

Synthesis and Physico-chemical Characterization of Nanohybrid Materials Based on Isonicotinic Acid Hydrazide

Banu¹,

Duceac²,

Mitrea³

et al. 2019

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“…Partial substitution of Mg/Al gives the possibility to develop positive charged layers balanced by anions and water molecules located in the interlayer space. A great advantage of these nanomaterials is that the metal cations can be substituted by others such as Fe, Zn, Co, Mn, Ni (divalents) and Co, Cr, V, Ga (trivalents) and also the interlayer anions can be replaced by a wide variety of inorganic or organic anions [4][5][6][7][8][9][10][11][12][13][14][15][16].…”

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confidence: 99%

Ceftriaxone Intercalated Nanostructures Used to Improve Medical Treatment

Duceac¹,

Luca²,

Mitrea³

et al. 2018

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The development of antibiotic resistance in bacteria possesses a huge threat to public health by nullifying the effect of even the most efficient antibiotics. From years, LDHs type nanomaterials have been used as drug carriers for a wide variety of pharmaceutically active molecules due to their delivery properties, making these inorganic-organic nanohybrids very efficient antimicrobial agents. The major purpose of this work was to synthesize and characterize ceftriaxone intercalated layered nanostructures for further use to treat some infections, mostly of them child infections. The novel nanohybrid materials were prepared by ion exchange route and coprecipitation method. Structural and morphological characterization was performed by FTIR, EDX and SEM techniques. The results revealed a high incorporation of the drug in the interlayer space of promising nanostructures.

“…A particular property of LDHs nanostructures is their ability to encapsulate large molecules as antibiotics which inhibits pathogen proliferation [10][11][12][13].…”

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confidence: 99%

Antibiotic Encapsulated Nanomaterials with Application in Medical Area

Luca¹,

Duceac²,

Mitrea³

et al. 2018

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Novel materials belonging to the class of anionic clays are synthesized by investigating their properties at nano scale. Thus, hydrotalcites or layered double hydroxides (LDHs) were used as drug delivery carriers in order to prevent or to treat infections produced by some pathogen agents. Their physical and chemical properties allow them to include different molecules in the interlayer space and then to ensure their transport to the target. The current work reveals the obtaining of nanohybrid compounds type amoxicillin/clavulanic acid-layered double hydroxides (Amox/CA-LDHs) followed by structural and morphological characterization of these nanostructures for future applications as drug controlled release systems. IR spectroscopy and Scanning Electron Microscopy pointed out LDHs ability to incorporate the medicines without modification of therapeutic activity.