Antibiotic Encapsulated Nanomaterials with Application in Medical Area

The oxidative stress is linked to many chronic diseases.The aim of the study was to assess the oxidative stress in chronic suppurative otitis media. The prospective study included a group of 60 patients with different forms of chronic suppurative otitis media (CSOM), cholesteatoma recidivism and a control group of 30 healthy people. The total antioxidant capacity (TAC) and malondialdehyde (MDA) concentrations were determined in serum of thepatients. We noticed a significant lower mean of TAC levels (p[ 0.001) in patients with chronic suppurative otitis media (CSOM) with and without cholesteatoma compared to the control group. The MDA had significantly higher mean values (p[ 0.001) compared to the healthy group.The imbalance of antioxidant systems to oxidizing molecules plays an important role in the pathogenesis of CSOM with and without cholesteatoma.

Section: Resultsmentioning

confidence: 98%

The TAC and MDA Values in Patients with Chronic Suppurative Otitis Media

Şerban¹,

Bădescu²,

Palade³

et al. 2019

“…This system should be regarded as an integrated subsystem of the human body, any local manifestation having the potential to induce general changes, and these may also affect the homeostasis of the stomatognat system. [41][42][43] There are no specific pathognomonic oral lesions that may appear in diabetes, but the stomatognat system components are affected by illnesses that have an increased incidence, a more serious development, and more common complications in patients with DM than in others [44][45][46].…”

Section: Resultsmentioning

confidence: 99%

The Role of Chemical Factors in the Diabetes and the Prediabetes that Leads to Polimorfe Oro -Maxilo-Facial Alterations in Malformative Syndrome

Eşanu¹,

Constantin²,

Budacu³

et al. 2019

There is no doubt that many psycho-emotional factors interfere with and produce changes in reproduction. Neglecting them means depriving our actions of efficiency because they will be incomplete. The adoption of the general term malformation syndrome to encompass all malformations draws attention on policy conditions set and communicate any teratologic process. Being a metabolic disease with clinical manifestations and multiple biochemical alterations, diabetes is a frightening scar of our century, considered to be the most important disease, which in itself leads to buccal-maxillo-facial polymorphic alterations. The study group consisted of 90 patients with congenital diabetes and stomatologic problems, aged between 26 and 65 years, the average age being 45 years. Distribution by gender: 60 men and30 women. Periodontal lesions are disturbing or distressing inflammation hyperplasic tissues of periodontium and quantity independence tissue affected to delineate both gingivitis and periodontitis. The most important factor in the epidemiology of the periodontal disease for prophylaxis is oral hygiene.

“…Estrogen expresion suppression and progesterone receptors activation represent the essential target for current drugs, and also for research and new drugs development. The most used and studied agents for endometriosis treatment are oral GnRH antagonists, aromatase inhibitors SERMs (Selective Estrogen Receptors Modulators) and SPRMs [17][18][19]. UPA is generally prescribed for conservative treatment of fibroids to preserve fertility.…”

Section: Resultsmentioning

confidence: 99%

The Impact of Ulipristal Acetate (UPA) versus Dienogest on Pain Related to Endometriomas Evaluated with Visual Analogue Scale (VAS)

Sima¹,

Albu²,

Ionescu³

et al. 2019

Visual analogue scale (VAS) is a psychometric scale applied to measure subjective characteristics. The purpose of our study was to evaluate the efficiency of Ulipristal acetate (UPA) compared with Dienogest for endometriomas related pain using VAS. We performed a randomized study on women with symptomatic endometriomas. The study was realized between January 2016�December 2018. The patients were randomized in two groups: Group A- that received UPA in doses of 5 mg daily for 12�13 weeks and Group B that received 2 mg Dienogest for 12�13 weeks. Each group received de VAS (Visual Analogue Scale) questionnaire before and after treatment. 70 women wereincluded in the study with 35 patients for each group. The age the mean age was 30.20 years. For Numeric Rating Scale before treatment in the group with UPA the median value was 6 (CI= 5.26, 6.51) and for group B the median was 5 (CI= 5.13, 5.66). After treatment for group A the median value was 4 (CI= 3.58, 4.29) and for group B the median value 4 (CI= 4.23, 4.6). For FRS before treatment in the group with UPA median value was 6 (CI= 5.87, 6.58) and for the group B median was 6 (CI= 6.16, 6.57). After treatment for group A the median value was 4 (CI= 4.12, 4.73) and for group B the median value 5 (CI= 4.9, 5.06). The pain significantly improved for group A. (p[ 0.05) VAS represent a good method to evaluate the quality of pain for patients with endometriomas. The UPA and Dienogest treatment improve the VAS parameters with better results for UPA in the present study.