The TAC and MDA Values in Patients with Chronic Suppurative Otitis Media

Şerban, Roxana; Bădescu, Codruţa; Palade, Dragoș Octavian; Bădescu, Magda; Filip, Catalina; Diaconu, Iulia; Mocrei, Ariadna; Haba, Danisia; Cobzeanu, Mihail Dan

doi:10.37358/rc.19.4.7131

Cited by 1 publication

(2 citation statements)

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“…The incidence of cholesteatoma is estimated at 9 per 100,000 people. Many factors are involved in the pathophysiology, such as the presence of osteoclastic activity, cytokines, chronic inflammation, endotoxins and lipid peroxidation products, where these factors also lead to the production of free oxygen radicals (Serban, Badescu, Palade, Badescu, Filip, Diaconu, & Cobzeanu, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…In many pathological conditions, there is accelerated formation of reactive oxygen species (ROS), resulting in an imbalance between oxidative factors and protective antioxidant systems. Reactive oxygen species (ROS) are important pathological mediators of many diseases under normal physiological conditions (Serban et al, 2019;Harabagiu, Cosgarea, Mogoantă, Leucuţa, & Maniu, 2017).…”

Section: Discussionmentioning

confidence: 99%

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Correlation between interleukin 17 (IL-17) levels and malondialdehyde (MDA) levels in patients with chronic suppurative otitis media

Sudrajad,

Kandhi,

Yudha

2024

Internat.Jrnl.

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Background: Otitis media is one of the most common causes of fever in the pediatric population. CSOM or also called chronic otitis media is an ear disease condition where a chronic infection is found in the middle ear without an intact tympanic membrane. Oxygen free radical levels and deficiency of antioxidant defense complexes may be involved in the pathogenesis of chronic suppurative otitis media. The IL-17 pathway plays an important role in the pathogenesis of otitis media by increasing ROS including MDA levels. Purpose: To analyze the levels of interleukin 17 (IL-17) and malondialdehyde (MDA) in chronic suppurative otitis media patients. Method: Analytical observational research with a cross sectional approach was conducted in December 2022 at RSUD Dr. Moewardi, the research sample was a patient with chronic suppurative otitis media without active phase cholesteatoma. Sampling used consecutive sampling, namely a non-random sampling method, so that a sample size of 40 participants was obtained, divided into two groups, namely the CSOM group and the healthy group. The data analysis used is univariate and bivariate analysis using parametric tests, namely the product moment correlation test and if it is not normally distributed (p-value <0.05) then use the Spearman rank correlation test. Results: The mean IL-17 level in the CSOM group was 78.76 ± 28.01 and the healthy group was 47.68 ± 21.75 with p = 0.000 < 0.05. The mean MDA value in the CSOM group was 138.37 ± 123.96 and in the healthy group was 55.84 ± 47.37 with a p value = 0.008 < 0.05. Because the p value is <0.05 for the IL-7 and MDA variables, there is a significant difference between CSOM and the group of healthy people. The product moment correlation test obtained a correlation coefficient value of 0.623 with a p value = 0.000. Because the p value is <0.05, there is a significant positive relationship between IL-17 levels and MDA in the blood of chronic suppurative otitis media (CSOM) patients. Conclusion: There is a significant positive relationship between IL-17 levels and MDA in the blood of chronic suppurative otitis media (CSOM) patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%