The Role of Chemical  Factors in the Diabetes and the Prediabetes that Leads to Polimorfe Oro -Maxilo-Facial Alterations in Malformative Syndrome

Eşanu, Irina; Constantin, Iulian; Budacu, Cristian Constantin; Forna, Doriana Agop; Craiu, Mihai

doi:10.37358/rc.19.6.7286

Cited by 3 publications

(7 citation statements)

References 13 publications

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“…The best indicator of vitamin D status in the body is considered to be serum 25-hydroxyvitamin D, 25-[OH]D [1][2]. This is known to be the renal and nonrenal synthesis precursor for 1,25dihydroxyvitamin D, 1,25-[OH]2D (calcitriol) which, opposed to the previous, has a greater biological half-life of three weeks and higher circulating levels [3][4][5][6][7]. Serum 1,2D is the biologically active form of vitamin D that is responsible for most of the vitamin D actions and it does not cross the placenta [2].…”

Section: Metabolism Of Vitamin D During the Pregnancymentioning

confidence: 99%

“…It is necessary to underline that 1-alpha-hydroxylase is a product encoded in the CYP27B1 gene and is expressed in kidneys, deciduas, and placenta during pregnancy [3]. Another compound encoded in the CYP24A1 gene is 24-hydroxylase that is responsible for producing less potent vitamin D metabolites [3,4]. During pregnancy the levels of 1,25-[OH]2D increase by 100% or more, possibly due to the methylation of the CYP24A1 catabolic gene [3,4].…”

Section: Metabolism Of Vitamin D During the Pregnancymentioning

confidence: 99%

“…Another compound encoded in the CYP24A1 gene is 24-hydroxylase that is responsible for producing less potent vitamin D metabolites [3,4]. During pregnancy the levels of 1,25-[OH]2D increase by 100% or more, possibly due to the methylation of the CYP24A1 catabolic gene [3,4]. In this case, the activity of this gene decreases automatically with the activity of 24-hydroxylase [4].…”

Section: Metabolism Of Vitamin D During the Pregnancymentioning

confidence: 99%

“…Its action is focused on the three target organs, intestine, kidney, and bone, in which specific nuclear receptors (VDRs) are well expressed [3]. The studies and experiments conducted in vitro and in vivo have shown that vitamin D exerts other "non-calcium" actions also [1][2][3][4][5][6]. It was demonstrated that vitamin D receptors are located in the entire body tissues [1].…”

Section: Introductionmentioning

confidence: 99%

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Is There a Relation Between 25-Hydroxyvitamin D Deficiency and Gestational Diabetess

Petroaie¹,

Popovici²,

Cosmescu³

et al. 2020

Rev. Chim.

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One of the essential roles of vitamin D is to maintain a good state of health, its actions being extremely complex. In the past years, the role and involvement of vitamin D have been intensively discussed in a variety of physiological or pathological conditions. To be effective, vitamin D requires binding to specific nuclear receptors (VDRs) that are found in multiple tissues. Therefore, there is a great interest in studies focused on vitamin D in order to evaluate the potential functions and relations with gestational diabetes mellitus (GDM). This disease is defined by glucose intolerance with onset or first recognition during pregnancy. It presents an increased risk of later progression to type 2 diabetes. Now, gestational diabetes represents a global public health problem due to its increasing incidence and possible severe complications of pregnancy. This article centralizes recent studies focused on a possible link between vitamin D deficiency and gestational diabetes, knowing that in pregnant women the insufficiency or deficiency of that vitamin is a common thing.

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Section: Metabolism Of Vitamin D During the Pregnancymentioning

confidence: 99%

Section: Metabolism Of Vitamin D During the Pregnancymentioning

confidence: 99%

Section: Metabolism Of Vitamin D During the Pregnancymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Is There a Relation Between 25-Hydroxyvitamin D Deficiency and Gestational Diabetess

Petroaie¹,

Popovici²,

Cosmescu³

et al. 2020

Rev. Chim.

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View full text Add to dashboard Cite

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“…In the dischromic dysplasia due to tetracycline, tetracycline has the ability to deposit an organic matrix of a bone or the whole, before triggering calcification , as well. , it is not necessary for the caries to affect the child immediately after the temporary eruption, leading to their coronary destruction [28][29][30].…”

mentioning

confidence: 99%

Dental Dysplasia as Structural Anomalies nin Child Oral Pathogeny

2020

Rev.Chim.

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Dental dysplasia such as structural anomalies, complex pathogenic foundations, although of a relatively low incidence in the child oral pathology is of a a wide interest, attested to a considerable wealth of scientific material reserved in the specialized literature. The prevalence of defective enamel on permanent teeth in the maxilla is smaller in the jaw. The permanent superior incisors are in the first place from the point of view of frequency in the enamel defects, usually symmetric, either at the 2 central, or at all the 4. The first permanent molars and the premolars are permanently affected to a lesser extent, and on canines injuries occur very rarely, only in very serious cases (genetic). We have examined a number of 300 children school communities, with the chronological age between 6 and 11 years 195 girls (65%) and 105 boys (35%). On distribution of children in age groups, we found a concentration of distribution at the age of 8-9 yearsChanges to the DDE index in order to be efficiently and flawlessly divided by enamel defects, being suitable for screenings, but also for more detailed and larger studies, when they can be adapted to the research requirements. The most frequent affectation of the upper permanent incisors correlated with permanent primary molars, implies an intensification of the dental education activity oriented to the young schoolchildren, then the awareness of the dental factor in the facial aesthetics appears late, during puberty-adolescence when the lesions remain aggravate and the oral rehabilitation is complex and difficult, in these cases. Keywords: dental dysplasia, progress defects, enamel development

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The Role of Cellular Biology in Maxilo-facial Surgery and Protective Restorations

Onisor¹,

Budacu²,

C³

et al. 2020

Rev.Chim.

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The essential characteristics of contemporary dental medicine are the precision, avant-garde, technologization and successful clinical purpose of cell therapy with the prospect of further application in the clinical practice of cell therapy methods and other performance methods based on the knowledge of cell biology and regenerative medicine in full function ; despite the very different environments, such teeth can develop normal in adult jaw; thus, if suitable cells can be found that, by combination, produce immature teeth, there is the potential for bio- teeth to become a clinical reality .The maxillary frontal area represents the most important area of the maxillae from an aesthetic point of view and the prosthetic restoration of this area is of primary interest in ensuring the appearance, phonation, incision, in human communication and in the structuring of the individual personality. Affecting the maxillary frontal area or through coronary destruction consecutive cavities and their complications, discolouration, dental malpositions disgraceful or due to lack of dental periodontal units creates problem in the aesthetic prosthetics. These changes existing at the front arcade level cause major disturbances to the physiognomy, to the phonation. In the Clinic of Oral and Maxillofacial Surgery, in a period of 2 years, between 2016 and 2018, we noticed, solved and followed a number of 129 cases; 57 patients-lot endodontic and surgical therapy study; 72 patients, study group prosthetic restorations. Due to the functional role that the maxillary front teeth play, the corrections have to be made within the limits of functional tolerance that fall within the normal occlusal parameters because the functional disturbances dictated only by the aesthetics are not tolerated and can lead to large imbalances. The complex oral rehabilitation of the different clinical cases encountered in the dental practice is largely a challenge for the dentist due to the high degree of different affect but present on all the elements of the system. Keywords: cell therapy method , regenerative medicine, prosthetic restoration

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The Role of Chemical Factors in the Diabetes and the Prediabetes that Leads to Polimorfe Oro -Maxilo-Facial Alterations in Malformative Syndrome

Cited by 3 publications

References 13 publications

Is There a Relation Between 25-Hydroxyvitamin D Deficiency and Gestational Diabetess

Is There a Relation Between 25-Hydroxyvitamin D Deficiency and Gestational Diabetess

Dental Dysplasia as Structural Anomalies nin Child Oral Pathogeny

The Role of Cellular Biology in Maxilo-facial Surgery and Protective Restorations

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