Direct HPLC Analysis of cis- and trans-Resveratrol and Piceid Isomers in Spanish Red Vitis vinifera Wines

Lamuela‐Raventós, Rosa M.; Romero-Pérez, A. I.; Waterhouse, Andrew L.; Torre-Boronat, M. C. de la

doi:10.1021/jf00050a003

Cited by 255 publications

(176 citation statements)

References 11 publications

(16 reference statements)

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“…Resveratrol (3,5,4' -trihydroxystilbene) is a phytoalexin contained in a variety of plants, such as grapes, peanuts, berries and especially in the dried roots of a traditional Chinese medicine Polygonum cuspidatum Sieb. et Zucc (1,2).…”

Section: Introductionmentioning

confidence: 99%

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Anti-tumor effects and cellular mechanisms of resveratrol

Han

Xia

Gao

et al. 2015

DD&T

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Section: Introductionmentioning

confidence: 99%

“…et Zucc (1,2). It exists as two geometric isomers: cis-(Z) and trans-(E) (3), and the trans-form can undergo isomerization to the cis-form when exposed to ultraviolet irradiation (4).…”

Section: Introductionmentioning

confidence: 99%

Anti-tumor effects and cellular mechanisms of resveratrol

Han

Xia

Gao

et al. 2015

DD&T

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“…The high performance liquid chromatography (HPLC) tandem mass spectrometry (MS/MS) method was developed on the basis of the exiting literature on resveratrol determination in various matrices [10][11][12]. A C 18 stationary phase is preferred for chromatography because it has proved to be very effective in separating resveratrol and its metabolites in complicated biological samples such as urine and plasma low density lipoproteins [10], and also in wine [12].…”

Section: Lc-ms/ms Methods Developmentmentioning

confidence: 99%

LC-MS as a Tool to Overcome the Limitations of Self-Reported Dietary Assessments in the Determination of Wine Intake

et al. 2017

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Abstract:The nutritional assessment of individuals is usually performed using highly subjective data collecting tools such as food frequency questionnaires, dietary recalls and food records. However, people are not always capable of recalling all foods (and ingredients) consumed, and in some cases, the intake of specific foods is intentionally omitted. Even though wine is considered positive for cardiovascular status, and is an essential part of Mediterranean culture, individuals may not always report its consumption accurately due to the existence of social preconceptions about alcoholic beverages. In this study, the presence of free resveratrol has been determined in human plasma from 25 Spanish volunteers using liquid chromatography coupled to mass spectrometry (LC-MS). This phenolic compound proved to be useful as a dietary biomarker for wine intake in a known population, and the results were compared with those obtained by self-reported dietary assessments. However, certain limitations must also be taken into account such as inter-individual variations and the type of wine consumed. The LC-MS method was validated for trans-resveratrol determination in human plasma, with an LOD (limit of detection) of 50 ng·mL −1 and an LOQ (limit of quantification) of 150 ng·mL −1 , respectively.

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“…Numerous methods have been published for determining trans-resveratrol in liquid matrices such as grape juice, wine, urine, plasma, or blood 1,2,14,15,18,28,[30][31][32]34 . Most of them are direct analyses 1,2,15,18 .…”

Section: Introductionmentioning

confidence: 99%

“…Most of them are direct analyses 1,2,15,18 . In the case of liquid extraction, ethyl acetate is often used 14,32 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of Procedures for Resveratrol Analysis in Beer: Assessment of Stilbenoids Stability through Wort Fermentation and Beer Aging

Jerkovic¹,

Nguyen²,

Timmermans³

et al. 2008

Journal of the Institute of Brewing

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Three resveratrol extraction procedures were compared in beer. Two-step pre-cleaning with toluene and cyclohexane allows 76% trans-resveratrol recovery by solid-phase extraction (SPE) before RP-HPLC-MS/MS analysis. This procedure proved much more efficient than liquid/liquid extraction, which requires solvents that are too hydrophobic for stilbenoids. SPME-GC-MS, where the main limiting factor is non-reproducibility from fibre to fibre, is an interesting alternative for resveratrol quantification in complex mixtures where pre-cleaning is too difficult. With the optimized SPE procedure, 5 µg.L 1 trans-resveratrol was detected in four commercial beers. However, concentrations of stilbenoids in beer should be higher taking into account the presence of cis-stilbenoids. During fermentation, trans-resveratrol was partially regenerated from its glucoside, more stable through beer aging. Adding a stilbenoids-enriched ethanolic hop extract after fermentation significantly increases the beer stilbenoids potential.

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Direct HPLC Analysis of cis- and trans-Resveratrol and Piceid Isomers in Spanish Red Vitis vinifera Wines

Cited by 255 publications

References 11 publications

Anti-tumor effects and cellular mechanisms of resveratrol

Anti-tumor effects and cellular mechanisms of resveratrol

LC-MS as a Tool to Overcome the Limitations of Self-Reported Dietary Assessments in the Determination of Wine Intake

Comparison of Procedures for Resveratrol Analysis in Beer: Assessment of Stilbenoids Stability through Wort Fermentation and Beer Aging

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