Anti-tumor effects and cellular mechanisms of resveratrol

Han, Guohua; Xia, Jufeng; Gao, Jianjun; Inagaki, Yoshiaki; Tang, Wei; Kokudo, Norihiro

doi:10.5582/ddt.2015.01007

Cited by 86 publications

(53 citation statements)

References 84 publications

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“…Rapid glucuronidation and sulfation in enterocytes, hepatocytes, and other cells (e.g., [14][15][16][17][18][19][20][21]) and re-export to the intestinal lumen by MDR proteins [15,22,23], or possibly OATPs [24], are thought to limit the potential impact of this celebrated "natural drug" in vivo. This is a pity, given the pleiotropic effects this dietary compound is reported to have in important pathophysiological respects (for recent reviews see, e.g., [25][26][27][28][29][30]). Possibly its most widely discussed activities are as an activator of the deacetylase SIRT1 and a repressor of inflammation, to which one might add its estrogen-like features (e.g., [31][32][33][34][35][36][37][38]).…”

Section: Introductionmentioning

confidence: 99%

N-Monosubstituted Methoxy-oligo(ethylene glycol) Carbamate Ester Prodrugs of Resveratrol

et al. 2015

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Abstract:Resveratrol is a natural polyphenol with many interesting biological activities. Its pharmacological exploitation in vivo is, however, hindered by its rapid elimination via phase II conjugative metabolism at the intestinal and, most importantly, hepatic levels. One approach to bypass this problem relies on prodrugs. We report here the synthesis, characterization, hydrolysis, and in vivo pharmacokinetic behavior of resveratrol prodrugs in which the OH groups are engaged in an N-monosubstituted carbamate ester linkage. As promoiety, methoxy-oligo(ethylene glycol) groups (m-OEG) (CH3-[OCH2CH2]n-) of defined chain length (n = 3, 4, 6) were used. These are expected to modulate the chemico-physical properties of the resulting derivatives, much like longer poly(ethylene glycol) (PEG) chains, while retaining a relatively low MW and, thus, a favorable drug loading capacity. Intragastric administration to rats resulted in the appearance in the bloodstream of the prodrug and of the products of its partial hydrolysis, confirming protection from first-pass metabolism during absorption.

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Section: Introductionmentioning

confidence: 99%

N-Monosubstituted Methoxy-oligo(ethylene glycol) Carbamate Ester Prodrugs of Resveratrol

et al. 2015

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“…Diversos estudos têm indicado que o Rsv é um agente químico responsável por atividades anticancerígenas, bloqueando a evolução de processos neoplásicos e atuando nos três estágios do câncer (iniciação, promoção e progressão) (JANG et al, 1997;HAN et al, 2015). A sua capacidade de suprimir a proliferação celular, induzir apoptose e restringir a metástase e invasão em diversas linhagens celulares tem alavancado o interesse em larga escala por este composto como antitumoral (HAN et al, 2015).…”

Section: Artigo De Revisãounclassified

O potencial do resveratrol como quimioterápico para o câncer de pele: uma revisão

Zamin

Horn

2017

cmbio

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“…It has a protective effect on stress, injury, ultraviolet irradiation and fungal infection [27]. It has been demonstrated that resveratrol also has lots of other bioactivities [28] including cardiovascular-protection, antiinflammation, anti-aging effect [28,29].…”

mentioning

confidence: 99%

“…It has been demonstrated that resveratrol also has lots of other bioactivities [28] including cardiovascular-protection, antiinflammation, anti-aging effect [28,29]. Recent findings indicate resveratrol has strong anti-tumor potential against various types of cancer [27]. Resveratrol can inhibit tumor metasis [28,29] and invasion [29][30][31] as well.…”

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confidence: 99%

Resveratrol inhibits hypoxia-induced glioma cell migration and invasion by the p-STAT3/miR-34a axis

Wang¹,

Han²,

Zhang³

2016

neo

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Hypoxia promotes aggressiveness, angiogenesis and resistance in glioma. It has been reported that resveratrol has strong anti-tumor ability and can inhibit migration and invasion of varieties of tumor including glioma. However, whether resveratrol inhibits hypoxia-induced migration and invasion of glioma cells is still unknown. In this study, we found glioma U87 and U251 cells migration and invasion was reduced by resveratrol under hypoxia condition and higher doses led to stronger block, while proliferation of U87 and U251 cells was hardly effected. Mechanically, hypoxia-induced upregulation of phosphorylated signal transducer and activator of transcription 3(p-STAT3) was blocked by resveratrol. MicroRNA-34a (miR-34a) is a tumor suppressor whose promoter region has a conserved STAT3-binding site and can be negatively regulated by STAT3. Interestingly, miR-34a was downregulated under hypoxia but upregulated by resveratrol which was perhaps relevant to changes in level of p-STAT3. The effect of resveratrol on p-STAT3 and miR-34a was both time-and dose-dependent. Summarizing, resveratrol inhibits hypoxia-induced migration and invasion possibly via p-STAT3/miR-34a axis and this effect is both time-and dose-dependent.

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Anti-tumor effects and cellular mechanisms of resveratrol

Cited by 86 publications

References 84 publications

N-Monosubstituted Methoxy-oligo(ethylene glycol) Carbamate Ester Prodrugs of Resveratrol

N-Monosubstituted Methoxy-oligo(ethylene glycol) Carbamate Ester Prodrugs of Resveratrol

O potencial do resveratrol como quimioterápico para o câncer de pele: uma revisão

Resveratrol inhibits hypoxia-induced glioma cell migration and invasion by the p-STAT3/miR-34a axis

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