Direct-acting mutagenicity of extracts of coal burning-derived particulates and contribution of nitropolycyclic aromatic hydrocarbons

Taga, Rina; Tang, Ning; Hattori, Tetsuyuki; Tamura, Kenji; Sakai, Shunsuke; Toriba, Akira; Kizu, Ryoichi; Hayakawa, Kazuichi

doi:10.1016/j.mrgentox.2004.11.013

Cited by 41 publications

(16 citation statements)

References 18 publications

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“…NPAHs can be separately determined by HPLC with electrochemical detection (HPLCFCD) (Galceran and Moyano, 1993). Other papers concerning HPLC with chemiluminescence and fluorescence detections (CLD and FLD) for NPAHs have also been reported or reviewed (Hayakawa et al, 1992(Hayakawa et al, , 1999aTaga et al, 2005;Tang et al, 2004). The schematic diagram of typical HPLC/CLD analytical system is shown in Fig.…”

Section: Analytical Methods For Nitro-pahs and Other Pahs Derivativesmentioning

confidence: 99%

Development of analytical methods for polycyclic aromatic hydrocarbons (PAHs) in airborne particulates: A review

Liu

Lin

et al. 2007

Journal of Environmental Sciences

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Section: Analytical Methods For Nitro-pahs and Other Pahs Derivativesmentioning

confidence: 99%

Development of analytical methods for polycyclic aromatic hydrocarbons (PAHs) in airborne particulates: A review

Liu

Lin

et al. 2007

Journal of Environmental Sciences

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“…[9][10][11][12][13] It has also been detected in surface soil and rainwater, [14][15][16] probably as a consequence of atmospheric washout. More recently, 3-NBA has been detected in domestic coal-burning-derived particulates, 17 suggesting that it is a ubiquitous environmental contaminant. 3-NBA is genotoxic in various short-term bioassays, 9,18-21 being one of the most potent direct-acting mutagens ever recorded in the Salmonella typhimurium Ames assay.…”

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confidence: 99%

Identification of three major DNA adducts formed by the carcinogenic air pollutant 3‐nitrobenzanthrone in rat lung at the C8 and N² position of guanine and at the N⁶ position of adenine

Arlt

Schmeiser

Osborne

et al. 2005

Intl Journal of Cancer

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Abstract3‐Nitrobenzanthrone (3‐NBA) is a potent mutagen and potential human carcinogen identified in diesel exhaust and ambient air particulate matter. Previously, we detected the formation of 3‐NBA‐derived DNA adducts in rodent tissues by 32P‐postlabeling, all of which are derived from reductive metabolites of 3‐NBA bound to purine bases, but structural identification of these adducts has not yet been reported. We have now prepared 3‐NBA‐derived DNA adduct standards for 32P‐postlabeling by reacting N‐acetoxy‐3‐aminobenzanthrone (N‐Aco‐ABA) with purine nucleotides. Three deoxyguanosine (dG) adducts have been characterised as N‐(2′‐deoxyguanosin‐8‐yl)‐3‐aminobenzanthrone‐3′‐phosphate (dG3′p‐C8‐N‐ABA), 2‐(2′‐deoxyguanosin‐N2‐yl)‐3‐aminobenzanthrone‐3′‐phosphate (dG3′p‐N2‐ABA) and 2‐(2′‐deoxyguanosin‐8‐yl)‐3‐aminobenzanthrone‐3′‐phosphate (dG3′p‐C8‐C2‐ABA), and a deoxyadenosine (dA) adduct was characterised as 2‐(2′‐deoxyadenosin‐N6‐yl)‐3‐aminobenzanthrone‐3′‐phosphate (dA3′p‐N6‐ABA). 3‐NBA‐derived DNA adducts formed experimentally in vivo and in vitro were compared with the chemically synthesised adducts. The major 3‐NBA‐derived DNA adduct formed in rat lung cochromatographed with dG3′p‐N2‐ABA in two independent systems (thin layer and high‐performance liquid chromatography). This is also the major adduct formed in tissue of rats or mice treated with 3‐aminobenzanthrone (3‐ABA), the major human metabolite of 3‐NBA. Similarly, dG3′p‐C8‐N‐ABA and dA3′p‐N6‐ABA cochromatographed with two other adducts formed in various organs of rats or mice treated either with 3‐NBA or 3‐ABA, whereas dG3′p‐C8‐C2‐ABA did not cochromatograph with any of the adducts found in vivo. Utilizing different enzymatic systems in vitro, including human hepatic microsomes and cytosols, and purified and recombinant enzymes, we found that a variety of enzymes [NAD(P)H:quinone oxidoreductase, xanthine oxidase, NADPH:cytochrome P450 oxidoreductase, cytochrome P450s 1A1 and 1A2, N,O‐acetyltransferases 1 and 2, sulfotransferases 1A1 and 1A2, and myeloperoxidase] are able to catalyse the formation of 2‐(2′‐deoxyguanosin‐N2‐yl)‐3‐aminobenzanthrone, N‐(2′‐deoxyguanosin‐8‐yl)‐3‐aminobenzanthrone and 2‐(2′‐deoxyadenosin‐N6‐yl)‐3‐aminobenzanthrone in DNA, after incubation with 3‐NBA and/or 3‐ABA. © 2005 Wiley‐Liss, Inc.

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“…La mutagenicidad de las partículas diésel ha sido investigada por algunos autores (Singh et al 2004, Seung-Min y Chung 2006, Riger et al 2011) y se ha demostrado que inducen mutagenicidad en ausencia de enzimas microsomales (Taga et al 2005, Lingzhi et al 2007. Se ha descubierto que una gama más amplia de compuestos aromáticos policíclicos encontrados en las emisiones de combustión de diésel y en la contaminación del aire son a la vez mutagé-nicos y carcinogénicos como los nitroarenos, entre los que se incluyen a las lactonas del nitropireno y nitrofenantreno y a la 3-nitrobenzantrona que es un potente mutágeno encontrado en las partículas de diésel.…”

Section: Resultados Y Discusiónunclassified

Actividad Mutagénica Inducida Por Hidrocarburos Aromáticos Policíclicos en Muestras De PM2.5 en Un Sector Residencial De Villa Del Rosario-Norte De Santander, Colombia

Gélvez

Vargas

Parra

2016

Rev. Int. Contam. Ambie.

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Palabras clave: cromatografía de gases, material particulado, ensayo de Ames, Salmonella typhimurium TA98 y TA100 RESUMENLos contaminantes del aire, especialmente el material particulado (MP), han sido investigados como posibles agentes responsables del cáncer de pulmón. Varios componentes del MP como los hidrocarburos aromáticos policíclicos (HAP) pueden contribuir con efectos adversos sobre la salud. La contaminación atmosférica junto con la ingesta de alimentos contaminados, son la vía primaria de la exposición humana a los HAP. Los HAP en general, son sospechosos de ser carcinogénicos, aunque el nivel sea muy bajo. La principal característica sobre la salud, es su capacidad de inducir cáncer en los organismos expuestos. El transporte vehicular es la fuente más importante de emisiones contaminantes atmosféricas y contribuye con más del 60 % de las emisiones de HAP. El objetivo de este trabajo fue determinar la mutagenicidad de muestras de PM 2.5 , provenientes del aire de Villa del Rosario, norte de Santander, Colombia e identificar los HAP. La identificación se realizó por medio de cromatografía de gases con detector de ionización de llama. Los ensayos mutagénicos se realizaron por el prueba de Ames en cepas de Salmonella typhimurium TA98 y TA 100.Key words: gas chromatography, particulate matter, Ames test, Salmonella typhimuriium TA98 and TA100 ABSTRACTAir pollutants, especially particulate matter (PM) have been investigated as potential agents responsible for lung cancer. Several components of the PM such as polycyclic aromatic hydrocarbons (PAHs) can contribute to adverse health effects. Air pollution, along with the intake of contaminated foods, are the primary route of human exposure to PAHs. PAHs are generally suspected of being carcinogenic at some degree. Although the level is very low, the main health risk associated with PHAs, is its ability to induce cancer in exposed organisms. The vehicular transport is the largest and most important source of atmospheric emissions that contribute over 60 % of PAH emissions. The aim of this study was to determine the mutagenicity of PM2.5 samples, from the air in Villa Rev. Int. Contam.

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Direct-acting mutagenicity of extracts of coal burning-derived particulates and contribution of nitropolycyclic aromatic hydrocarbons

Cited by 41 publications

References 18 publications

Development of analytical methods for polycyclic aromatic hydrocarbons (PAHs) in airborne particulates: A review

Development of analytical methods for polycyclic aromatic hydrocarbons (PAHs) in airborne particulates: A review

Identification of three major DNA adducts formed by the carcinogenic air pollutant 3‐nitrobenzanthrone in rat lung at the C8 and N² position of guanine and at the N⁶ position of adenine

Actividad Mutagénica Inducida Por Hidrocarburos Aromáticos Policíclicos en Muestras De PM2.5 en Un Sector Residencial De Villa Del Rosario-Norte De Santander, Colombia

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Direct-acting mutagenicity of extracts of coal burning-derived particulates and contribution of nitropolycyclic aromatic hydrocarbons

Cited by 41 publications

References 18 publications

Development of analytical methods for polycyclic aromatic hydrocarbons (PAHs) in airborne particulates: A review

Development of analytical methods for polycyclic aromatic hydrocarbons (PAHs) in airborne particulates: A review

Identification of three major DNA adducts formed by the carcinogenic air pollutant 3‐nitrobenzanthrone in rat lung at the C8 and N2 position of guanine and at the N6 position of adenine

Actividad Mutagénica Inducida Por Hidrocarburos Aromáticos Policíclicos en Muestras De PM2.5 en Un Sector Residencial De Villa Del Rosario-Norte De Santander, Colombia

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Identification of three major DNA adducts formed by the carcinogenic air pollutant 3‐nitrobenzanthrone in rat lung at the C8 and N² position of guanine and at the N⁶ position of adenine