Actividad Mutagénica Inducida Por Hidrocarburos Aromáticos Policíclicos en Muestras De PM2.5 en Un Sector Residencial De Villa Del Rosario-Norte De Santander, Colombia

Abstract

Palabras clave: cromatografía de gases, material particulado, ensayo de Ames, Salmonella typhimurium TA98 y TA100 RESUMENLos contaminantes del aire, especialmente el material particulado (MP), han sido investigados como posibles agentes responsables del cáncer de pulmón. Varios componentes del MP como los hidrocarburos aromáticos policíclicos (HAP) pueden contribuir con efectos adversos sobre la salud. La contaminación atmosférica junto con la ingesta de alimentos contaminados, son la vía primaria de la exposición humana a los HAP. Los HAP en general, son sospechosos de ser carcinogénicos, aunque el nivel sea muy bajo. La principal característica sobre la salud, es su capacidad de inducir cáncer en los organismos expuestos. El transporte vehicular es la fuente más importante de emisiones contaminantes atmosféricas y contribuye con más del 60 % de las emisiones de HAP. El objetivo de este trabajo fue determinar la mutagenicidad de muestras de PM 2.5 , provenientes del aire de Villa del Rosario, norte de Santander, Colombia e identificar los HAP. La identificación se realizó por medio de cromatografía de gases con detector de ionización de llama. Los ensayos mutagénicos se realizaron por el prueba de Ames en cepas de Salmonella typhimurium TA98 y TA 100.Key words: gas chromatography, particulate matter, Ames test, Salmonella typhimuriium TA98 and TA100 ABSTRACTAir pollutants, especially particulate matter (PM) have been investigated as potential agents responsible for lung cancer. Several components of the PM such as polycyclic aromatic hydrocarbons (PAHs) can contribute to adverse health effects. Air pollution, along with the intake of contaminated foods, are the primary route of human exposure to PAHs. PAHs are generally suspected of being carcinogenic at some degree. Although the level is very low, the main health risk associated with PHAs, is its ability to induce cancer in exposed organisms. The vehicular transport is the largest and most important source of atmospheric emissions that contribute over 60 % of PAH emissions. The aim of this study was to determine the mutagenicity of PM2.5 samples, from the air in Villa Rev. Int. Contam.

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