Diminished phospholipid incorporation of essential fatty acids in peripheral blood leucocytes from patients with Crohn's disease: correlation with zinc depletion.

Cunnane, S. C.; Ainley, Colin; Keeling, P. W. N.; Thompson, R. P. H.; Crawford, M. A.

doi:10.1080/07315724.1986.10720148

Cited by 15 publications

(5 citation statements)

References 12 publications

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“…The authors attributed this relationship to zinc being a relevant co-factor for essential FAs metabolism. A similar finding was found in plasma and cells ( 21 , 22 ). In addition, the deficiency of zinc in different contexts was shown to have an association with reduced essential FAs in serum samples ( 23 , 24 ).…”

Section: Discussionsupporting

confidence: 86%

Breast Milk Lipidome Is Associated With Maternal Diet and Infants' Growth

et al. 2022

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ObjectivesThe fatty acid (FA) composition of breast milk is a relevant aspect related to the development of the lactating infant. The present study aimed at exploring correlations between dietary intake of macro- and micronutrients with the FA profile in breast milk, and the possible implication for infants' growth.Study DesignBreast milk samples from a cohort of lactating women were collected 7–15 days postpartum. The FA profiles in triacylglycerol (TAG) and phospholipid (PL)-rich fractions were analyzed by gas chromatography. Diet was registered during the third trimester of pregnancy by means of a food frequency questionnaire (FFQ). In addition, anthropometric measurements of infants were collected from gestation and up to 12 months postpartum.ResultsThe FA profile in breast milk was characterized by a median of 37.4, 41.3 and 16.8% of saturated, monounsaturated, and polyunsaturated FAs, respectively. From the dietary components, zinc, iron, and B group vitamins were correlated positively with the proportion of total n-3 FAs in TAG and C20:5 n-3 in PL. Lycopene, vitamin E, zinc, and vitamin B2 showed a similar correlation with total polyunsaturated fatty acid (PUFA), total n-6 FAs, C20:4 n-6, and C18:2 n-6 in TAG. Regarding food groups, nuts showed the strongest association with several PUFA both in TAG and PL, while the vegetable group was also positively associated with C18:3 n-3. Furthermore, the concentration of linolenic acid (C18:3 n-3) and palmitic acid (C16:0) were positively associated with increased length for age (LFA) and weight for age (WFA) at 12 months compared with birth [ΔLFA −0.16 (−0.85, 0.37); ΔWFA −0.26 (−0.77, 0.21)].ConclusionsMothers' intake of nuts, dietary sources of zinc, iron, and B group vitamins were identified as potential predictors of a high-unsaturated FA profile in breast milk. In addition, linolenic and palmitic acids in breast milk were positively associated with infants' growth in the first year of life.

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Section: Discussionsupporting

confidence: 86%

Breast Milk Lipidome Is Associated With Maternal Diet and Infants' Growth

et al. 2022

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“…Furthermore, the significant positive correlation, which was found between the concentrations of zinc and AA in the breast milk, suggests that zinc may be an important co‐factor for EFA metabolism. A similar relationship has been found in plasma and cells (11,27).…”

Section: Discussionsupporting

confidence: 84%

Breast milk levels of zinc and ω‐6 polyunsaturated fatty acids and growth of healthy Chinese infants

2007

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“…The cloning of mammalian D5D and D6D cDNAs has increased our understanding of the molecular basis of the nutritional regulation of these desaturases [15,16] , for example suppression of D5D and D6D activities by dietary PUFAs was shown to be associated with decreased D5D and D6D mRNA levels [15,16] . In addition, human peripheral blood leucocytes have been extensively studied in relation to essential fatty acids (EFAs) and eicosanoid metabolism, and gene expression both in health and disease [9,[17][18][19][20][21][22] . Since the Chinese have dietary habits that differ substantially from Europeans, we compared, in this study, the composition of fatty acids (FAs) in the diet and expression of D5D and D6D genes between Chinese and European subjects.…”

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confidence: 99%

Diet and Gene Expression: Delta-5 and Delta-6 Desaturases in Healthy Chinese and European Subjects

Xiang

Rahman

et al. 2006

Ann Nutr Metab

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Aim: To compare the composition of fatty acids (FAs) in diet, and the expression of delta-6 desaturase (D6D) and delta-5 desaturase (D5D) genes in peripheral blood mononuclear cells (PBMCs) between Chinese and Europeans. Methods: Three-day dietary records from 20 subjects from Beijing, China (n = 10) and Kent, UK (n = 10) were analysed. Expression of PBMC D6D and D5D genes of the subjects was determined using RT-PCR. Results: The dietary intake of Chinese subjects contained less saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs), but more essential fatty acids (EFAs) than that of Europeans. Levels of expression of PBMC D6D and D5D genes of Chinese subjects were significantly lower than those of Europeans. A significant positive correlation was found between dietary intake of total SFAs and total MUFAs and expression of PBMC D6D and D5D genes, but a significant negative correlation between dietary intake of linoleic acid (LA) and α-linolenic acid (LNA) and the expression of PBMC D6D and D5D genes. Conclusion: Intake of high SFAs and MUFAs appears to increase expression of PBMC D6D and D5D genes, whilst high EFAs intake appears to decrease expression of PBMC D6D and D5D genes. A follow-up study of the expression of D6D and D5D genes in Chinese who live in European countries with high SFA and MUFA diets would be of interest.

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Diminished phospholipid incorporation of essential fatty acids in peripheral blood leucocytes from patients with Crohn's disease: correlation with zinc depletion.

Cited by 15 publications

References 12 publications

Breast Milk Lipidome Is Associated With Maternal Diet and Infants' Growth

Breast Milk Lipidome Is Associated With Maternal Diet and Infants' Growth

Breast milk levels of zinc and ω‐6 polyunsaturated fatty acids and growth of healthy Chinese infants

Diet and Gene Expression: Delta-5 and Delta-6 Desaturases in Healthy Chinese and European Subjects

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