Breast Milk Lipidome Is Associated With Maternal Diet and Infants' Growth

Calvo-Lerma, Joaquim; Selma‐Royo, Marta; Hervás, David; Yang, Baoru; Intonen, Linda; González, Sonia; Martínez‐Costa, Cecilia; Linderborg, Kaisa M.; Collado, María Carmen

doi:10.3389/fnut.2022.854786

Cited by 13 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dovetailing on the seminal study, other studies have found that breast milk composition is determined by the maternal diet [ 29 , 30 ], and suggest that the high presence of LA in breast milk primarily indicates the pervasiveness of LA in the food supply. An extensive body of literature on human breast milk fatty acids from different countries in Africa and South America also shows that the LA content in breast milk varies widely depending on maternal lipid nutrition [ 31 , 32 ].…”

Section: Presence Of La In Human Breast Milk and Relevance To Human N...mentioning

confidence: 85%

Linoleic Acid: A Narrative Review of the Effects of Increased Intake in the Standard American Diet and Associations with Chronic Disease

Mercola

D’Adamo

2023

Nutrients

View full text Add to dashboard Cite

The intake of linoleic acid (LA) has increased dramatically in the standard American diet. LA is generally promoted as supporting human health, but there exists controversy regarding whether the amount of LA currently consumed in the standard American diet supports human health. The goal of this narrative review is to explore the mechanisms that underlie the hypothesis that excessive LA intake may harm human health. While LA is considered to be an essential fatty acid and support health when consumed in modest amounts, an excessive intake of LA leads to the formation of oxidized linoleic acid metabolites (OXLAMs), impairments in mitochondrial function through suboptimal cardiolipin composition, and likely contributes to many chronic diseases that became an epidemic in the 20th century, and whose prevalence continues to increase. The standard American diet comprises 14 to 25 times more omega-6 fatty acids than omega-3 fatty acids, with the majority of omega-6 intake coming from LA. As LA consumption increases, the potential for OXLAM formation also increases. OXLAMs have been associated with various illnesses, including cardiovascular disease, cancer, and Alzheimer’s disease, among others. Lowering dietary LA intake can help reduce the production and accumulation of OXLAMs implicated in chronic diseases. While there are other problematic components in the standard American diet, the half-life of LA is approximately two years, which means the damage can be far more persistent than other dietary factors, and the impact of reducing excessive LA intake takes time. Therefore, additional research-evaluating approaches to reduce OXLAM formation and cardiolipin derangements following LA consumption are warranted.

show abstract

Section: Presence Of La In Human Breast Milk and Relevance To Human N...mentioning

confidence: 85%

Linoleic Acid: A Narrative Review of the Effects of Increased Intake in the Standard American Diet and Associations with Chronic Disease

Mercola

D’Adamo

2023

Nutrients

View full text Add to dashboard Cite

show abstract

“…In our study, maternal intake of dietary fat and/or fat components and vitamin E were associated with both infant WAZ and HCAZ but not LAZ during the first 6 months of lactation. Mothers of infants with normal weight (WAZ ≥ −1SD) had higher intakes of total calories and carbohydrates and higher intakes of energy and fat including total fat, MUFA, PUFA, and vitamin E. Mothers of infants with normal head-circumference (HCAZ ≥ −1 SD) also consumed higher MUFA and vitamin E. Previous studies investigating maternal intakes of dietary fat and fat components have described associations of higher dietary fat and fat component intakes with higher infant adiposity during the first 6 months of lactation ( 70 ) and higher lipid components in breast milk with infant of length and weight up to 12 months postpartum ( 71 ).…”

Section: Discussionmentioning

confidence: 99%

Human milk microbiome: associations with maternal diet and infant growth

Ajeeb,

Gonzalez,

Solomons

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

IntroductionIngestion of human milk (HM) is identified as a significant factor associated with early infant gut microbial colonization, which has been associated with infant health and development. Maternal diet has been associated with the HM microbiome (HMM). However, a few studies have explored the associations among maternal diet, HMM, and infant growth during the first 6 months of lactation.MethodsFor this cross-sectional study, Mam-Mayan mother-infant dyads (n = 64) were recruited from 8 rural communities in the Western Highlands of Guatemala at two stages of lactation: early (6–46 days postpartum, n = 29) or late (109–184 days postpartum, n = 35). Recruited mothers had vaginally delivered singleton births, had no subclinical mastitis or antibiotic treatments, and breastfed their infants. Data collected at both stages of lactation included two 24-h recalls, milk samples, and infant growth status indicators: head-circumference-for-age-z-score (HCAZ), length-for-age-z-score (LAZ), and weight-for-age-z-score (WAZ). Infants were divided into subgroups: normal weight (WAZ ≥ −1SD) and mildly underweight (WAZ < −1SD), non-stunted (LAZ ≥ −1.5SD) and mildly stunted (LAZ < −1.5SD), and normal head-circumference (HCAZ ≥ −1SD) and smaller head-circumference (HCAZ < −1SD). HMM was identified using 16S rRNA gene sequencing; amplicon analysis was performed with the high-resolution ANCHOR pipeline, and DESeq2 identified the differentially abundant (DA) HMM at the species-level between infant growth groups (FDR < 0.05) in both early and late lactation.ResultsUsing both cluster and univariate analyses, we identified (a) positive correlations between infant growth clusters and maternal dietary clusters, (b) both positive and negative associations among maternal macronutrient and micronutrient intakes with the HMM at the species level and (c) distinct correlations between HMM DA taxa with maternal nutrient intakes and infant z-scores that differed between breast-fed infants experiencing growth faltering and normal growth in early and late lactation.ConclusionCollectively, these findings provide important evidence of the potential influence of maternal diet on the early-life growth of breastfed infants via modulation of the HMM.

show abstract

“…The influence of maternal nutrition on BM macronutrients has been extensively studied [57][58][59]. Evidence also suggests that maternal diet modulates BM bioactive compounds, such as lipids [60,61], antioxidants [62,63], and hormones [64]. In poor settings, the lack of quality proteins affects BM cytokine levels [19].…”

Section: Discussionmentioning

confidence: 99%

Maternal and Neonatal Factors Modulating Breast Milk Cytokines in the First Month of Lactation

et al. 2023

View full text Add to dashboard Cite

Breast milk (BM) cytokines support and modulate infant immunity, being particularly relevant in premature neonates with adverse outcomes (NAO). This study aimed to examine, in a cohort of Spanish breastfeeding women, changes in BM cytokines in the first month of lactation, their modulation by neonatal factors (sex, gestational age, and NAO), maternal factors (obstetric complications, C-section, and diet), and their relationship with oxidative status. Sixty-three mother-neonate dyads were studied at days 7 and 28 of lactation. Dietary habits were assessed by a 72-h dietary recall, and the maternal dietary inflammatory index (mDII) was calculated. BM cytokines (IL-10, IL-13, IL-8, MCP-1, and TNFα) were assessed by ultra-sensitive chemiluminescence. Total antioxidant capacity was assessed by the ABTS method and lipid peroxidation by the MDA+HNE kit. From days 7 to 28 of lactation, the levels of IL-10 and TNFα remained stable, while IL-13 increased (β = 0.85 ± 0.12, p < 0.001) and IL-8 and MCP-1 levels decreased (β = −0.64 ± 0.27, p = 0.019; β = −0.98 ± 0.22, p < 0.001; respectively). Antioxidant capacity and lipid peroxidation also decrease during lactation. Neonatal sex did not influence any of the cytokines, but BM from mothers with male infants had a higher antioxidant capacity. Gestational age was associated with male sex and NAO, being inversely correlated with the BM proinflammatory cytokines IL-8, MCP-1, and TNFα. From days 7 to 28 of lactation, BM from women with NAO infants increased MCP-1 levels and had a larger drop in antioxidant capacity, with the opposite trend in lipid peroxidation. MCP-1 was also significantly higher in women undergoing C-section; this cytokine declined in women who decreased mDII during lactation, while IL-10 increased. Linear mixed regression models evidenced that the most important factors modulating BM cytokines were lactation period and gestational age. In conclusion, during the first month of lactation, BM cytokines shift towards an anti-inflammatory profile, influenced mainly by prematurity. BM MCP-1 is associated with maternal and neonatal inflammatory processes.

show abstract

Breast Milk Lipidome Is Associated With Maternal Diet and Infants' Growth

Cited by 13 publications

References 33 publications

Linoleic Acid: A Narrative Review of the Effects of Increased Intake in the Standard American Diet and Associations with Chronic Disease

Linoleic Acid: A Narrative Review of the Effects of Increased Intake in the Standard American Diet and Associations with Chronic Disease

Human milk microbiome: associations with maternal diet and infant growth

Maternal and Neonatal Factors Modulating Breast Milk Cytokines in the First Month of Lactation

Contact Info

Product

Resources

About