Dim light at night provokes depression-like behaviors and reduces CA1 dendritic spine density in female hamsters

Bedrosian, Tracy A.; Fonken, Laura K.; Walton, James C.; Haim, Abraham; Nelson, Randy J.

doi:10.1016/j.psyneuen.2011.01.004

Cited by 138 publications

(139 citation statements)

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“…For example, disruption of circadian rhythms is associated with mood disorder in humans, and causes depressive behaviour and neurobiological changes in animals. [40] Lack of exposure to sunlight, isolation and reduced opportunities to engage in social activity and family life could also contribute to negative effects of shiftwork on mood. Mood and metabolic disorders are frequent co-morbidities, [41,42] with overlapping pathophysiology (eg inflammation, insulin resistance, neurocognitive deficits), and animal studies link central insulin resistance to behavioural changes.…”

Section: Discussionmentioning

confidence: 99%

Adverse metabolic and mental health outcomes associated with shiftwork in a population-based study of 277,168 workers in UK biobank

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Adverse metabolic and mental health outcomes associated with shiftwork in a population-based study of 277,168 workers in UK biobank

et al. 2017

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“…Animals experiencing both dLAN and IH increased depressive-like responses similar to patients with OSA (36). Because dLAN increases depressive-like responses in rodents (2,8), presumably dLAN interacted with IH to alter behavior. Circadian disruption has been linked to depression in both clinical and animal studies (22,40).…”

Section: Discussionmentioning

confidence: 99%

“…In hamsters, dim light at night (dLAN) increases depressive-like behaviors and reduces CA1 dendritic spine density (2). Increased depressive-like behavior, as well as reduced anxiety, has also been observed in mice in response to light at night (2,8). The mood alterations observed in response to light at night, particularly depression, are similar to the results of OSA (1,20).…”

mentioning

confidence: 80%

“…The hemisphere of brain used for Golgi-Cox staining or RNAlater (Applied Biosystems, Foster City, CA) was randomly selected. Golgi-Cox-stained brains were stored, processed, and analyzed, as described previously (2).…”

Section: Tissue Collection and Processingmentioning

confidence: 99%

“…However, several studies have reported deleterious effects of light at night on individuals' health, including mood and obesity (10,16,46). In hamsters, dim light at night (dLAN) increases depressive-like behaviors and reduces CA1 dendritic spine density (2). Increased depressive-like behavior, as well as reduced anxiety, has also been observed in mice in response to light at night (2,8).…”

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confidence: 99%

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Dim light at night interacts with intermittent hypoxia to alter cognitive and affective responses

Aubrecht

Weil

Magalang

et al. 2013

American Journal of Physiology-Regulatory, Integrative and Comp

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Aubrecht TG, Weil ZM, Magalang UJ, Nelson RJ. Dim light at night interacts with intermittent hypoxia to alter cognitive and affective responses. Am J Physiol Regul Integr Comp Physiol 305: R78 -R86, 2013. First published May 8, 2013 doi:10.1152/ajpregu.00100.2013 and dim light at night (dLAN) have both been independently associated with alterations in mood and cognition. We aimed to determine whether dLAN would interact with intermittent hypoxia (IH), a condition characteristic of OSA, to alter the behavioral, cognitive, and affective responses. Adult male mice were housed in either standard lighting conditions (14:10-h light-dark cycle; 150 lux:0 lux) or dLAN (150 lux:5 lux). Mice were then exposed to IH (15 cycles/h, 8 h/day, FIO 2 nadir of 5%) for 3 wk, then tested in assays of affective and cognitive responses; brains were collected for dendritic morphology and PCR analysis. Exposure to dLAN and IH increased anxiety-like behaviors, as assessed in the open field, elevated plus maze, and the light/dark box. dLAN and IH increased depressive-like behaviors in the forced swim test. IH impaired learning and memory performance in the passive avoidance task; however, no differences were observed in spatial working memory, as assessed by y-maze or object recognition. IH combined with dLAN decreased cell body area in the CA1 and CA3 regions of the hippocampus. Overall, IH decreased apical spine density in the CA3, whereas dLAN decreased spine density in the CA1 of the hippocampus. TNF-␣ gene expression was not altered by IH or lighting condition, whereas VEGF expression was increased by dLAN. The combination of IH and dLAN provokes negative effects on hippocampal dendritic morphology, affect, and cognition, suggesting that limiting nighttime exposure to light in combination with other established treatments may be of benefit to patients with OSA.

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Dim Light at Night Promotes Circadian Disruption in Female Rats, at the Metabolic, Reproductive, and Behavioral Level

et al. 2023

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Inhabitants of urban areas are constantly exposed to light at night, which is an important environmental factor leading to circadian disruption. Streetlights filtering light through the windows and night dim light lamps are common sources of dim light at night (DLAN). The female population is susceptible to circadian disruption. The present study is aimed to determine the impact of DLAN on female Wistar rats circadian rhythms, metabolism, reproductive physiology, and behavior. After 5 weeks of DLAN exposure daily, oscillations in activity and body temperature of female rats are abolished. DLAN also decreases nocturnal food ingestion, which results in a diminishment in total food consumption. These alterations in the temporal organization of the body are associated with a significant decrease in melatonin plasmatic levels, reproductive disruptions, decreased exploration times, and marked anhedonia. This study highlights the importance of avoiding exposure to light at night, even at low intensities, to maintain the circadian organization of physiology, and denotes the great necessity of increasing the studies in females since the sexual dimorphism within the effects of desynchronizing protocols has been poorly studied.

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Dim light at night provokes depression-like behaviors and reduces CA1 dendritic spine density in female hamsters

Cited by 138 publications

References 38 publications

Adverse metabolic and mental health outcomes associated with shiftwork in a population-based study of 277,168 workers in UK biobank

Adverse metabolic and mental health outcomes associated with shiftwork in a population-based study of 277,168 workers in UK biobank

Dim light at night interacts with intermittent hypoxia to alter cognitive and affective responses

Dim Light at Night Promotes Circadian Disruption in Female Rats, at the Metabolic, Reproductive, and Behavioral Level

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