Dim Light at Night Promotes Circadian Disruption in Female Rats, at the Metabolic, Reproductive, and Behavioral Level

Gutiérrez‐Pérez, Mariana; González‐González, Shellye; Estrada‐Rodriguez, Karla P.; Espítia‐Bautista, Estefania; Guzmán-Ruiz, Mara; Escalona, René; Escobar, Carolina; Guerrero‐Vargas, Natalí N.

doi:10.1002/adbi.202200289

Cited by 3 publications

(1 citation statement)

References 101 publications

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“…More chronic exposure to dim light at night (i.e., for at least 2 weeks) in male rats leads to increased lipid storage in the liver and severely impairs the daily expression of many metabolic genes in the liver and white adipose tissue [ 67 , 68 ]. Furthermore, chronic exposure to dim light at night in female rats flattens the rest–activity rhythm, reduces nocturnal food intake, blunts the estrous cycle, and triggers anhedonia [ 69 ]. In humans, a longitudinal study has revealed that long-term exposure to light during the night period is associated with increased atherosclerosis [ 70 ].…”

Section: Effects Of Circadian Rhythms On Metabolismmentioning

confidence: 99%

Reciprocal Interactions between Circadian Clocks, Food Intake, and Energy Metabolism

Grosjean

Simonneaux

Challet

2023

Biology

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Like other biological functions, food intake and energy metabolism display daily rhythms controlled by the circadian timing system that comprises a main circadian clock and numerous secondary clocks in the brain and peripheral tissues. Each secondary circadian clock delivers local temporal cues based on intracellular transcriptional and translational feedback loops that are tightly interconnected to intracellular nutrient-sensing pathways. Genetic impairment of molecular clocks and alteration in the rhythmic synchronizing cues, such as ambient light at night or mistimed meals, lead to circadian disruption that, in turn, negatively impacts metabolic health. Not all circadian clocks are sensitive to the same synchronizing signals. The master clock in the suprachiasmatic nuclei of the hypothalamus is mostly synchronized by ambient light and, to a lesser extent, by behavioral cues coupled to arousal and exercise. Secondary clocks are generally phase-shifted by timed metabolic cues associated with feeding, exercise, and changes in temperature. Furthermore, both the master and secondary clocks are modulated by calorie restriction and high-fat feeding. Taking into account the regularity of daily meals, the duration of eating periods, chronotype, and sex, chrononutritional strategies may be useful for improving the robustness of daily rhythmicity and maintaining or even restoring the appropriate energy balance.

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Section: Effects Of Circadian Rhythms On Metabolismmentioning

confidence: 99%

Reciprocal Interactions between Circadian Clocks, Food Intake, and Energy Metabolism

Grosjean

Simonneaux

Challet

2023

Biology

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Association between exposure to outdoor artificial light at night during pregnancy and glucose homeostasis: A prospective cohort study

Zhang,

Wang,

et al. 2024

Environmental Research

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Disturbances of Hormonal Circadian Rhythms by Light Pollution

Zeman

Okuliarova

Rumanova

2023

IJMS

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The circadian rhythms evolved to anticipate and cope with cyclic changes in environmental conditions. This adaptive function is currently compromised by increasing levels of artificial light at night (ALAN), which can represent a risk for the development of diseases of civilisation. The causal links are not completely understood, and this featured review focuses on the chronodisruption of the neuroendocrine control of physiology and behaviour by dim ALAN. The published data indicate that low levels of ALAN (2–5 lux) can attenuate the molecular mechanisms generating circadian rhythms in the central oscillator, eliminate the rhythmic changes in dominant hormonal signals, such as melatonin, testosterone and vasopressin, and interfere with the circadian rhythm of the dominant glucocorticoid corticosterone in rodents. These changes are associated with a disturbed daily pattern of metabolic changes and behavioural rhythms in activity and food and water intake. The increasing levels of ALAN require the identification of the pathways mediating possible negative consequences on health to design effective mitigation strategies to eliminate or minimise the effects of light pollution.

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Dim Light at Night Promotes Circadian Disruption in Female Rats, at the Metabolic, Reproductive, and Behavioral Level

Cited by 3 publications

References 101 publications

Reciprocal Interactions between Circadian Clocks, Food Intake, and Energy Metabolism

Reciprocal Interactions between Circadian Clocks, Food Intake, and Energy Metabolism

Association between exposure to outdoor artificial light at night during pregnancy and glucose homeostasis: A prospective cohort study

Disturbances of Hormonal Circadian Rhythms by Light Pollution

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