Adverse metabolic and mental health outcomes associated with shiftwork in a population-based study of 277,168 workers in UK biobank

Wyse, Cathy; Morales, Carlos A. Celis; Graham, Nick; Yang, Fan; Ward, Joey; Curtis, Anne M.; Mackay, Daniel; Smith, Daniel J.; Bailey, Mark E.S.; Biello, Stephany M.; Gill, Jason M.R.; Pell, Jill P.

doi:10.1080/07853890.2017.1292045

Cited by 81 publications

(63 citation statements)

References 42 publications

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“…Abnormal circadian rhythms have been associated with obesity, T2DM, CVD and hypertension [3,23,30], all components of the Metabolic Syndrome. Shift workers or people who sleep poorly are more likely to develop obesity and T2DM due to circadian clock disruption [31][32][33][34][35][36][37].…”

Section: Metabolic Syndrome Components and Circadian Disruptionmentioning

confidence: 99%

The Circadian Syndrome: is the Metabolic Syndrome and much more!

Zimmet

Alberti

Stern³

et al. 2019

J Intern Med

222

192

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The Metabolic Syndrome is a cluster of cardio‐metabolic risk factors and comorbidities conveying high risk of both cardiovascular disease and type 2 diabetes. It is responsible for huge socio‐economic costs with its resulting morbidity and mortality in most countries. The underlying aetiology of this clustering has been the subject of much debate. More recently, significant interest has focussed on the involvement of the circadian system, a major regulator of almost every aspect of human health and metabolism. The Circadian Syndrome has now been implicated in several chronic diseases including type 2 diabetes and cardiovascular disease. There is now increasing evidence connecting disturbances in circadian rhythm with not only the key components of the Metabolic Syndrome but also its main comorbidities including sleep disturbances, depression, steatohepatitis and cognitive dysfunction. Based on this, we now propose that circadian disruption may be an important underlying aetiological factor for the Metabolic Syndrome and we suggest that it be renamed the ‘Circadian Syndrome’. With the increased recognition of the ‘Circadian Syndrome’, circadian medicine, through the timing of exercise, light exposure, food consumption, dispensing of medications and sleep, is likely to play a much greater role in the maintenance of both individual and population health in the future.

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Section: Metabolic Syndrome Components and Circadian Disruptionmentioning

confidence: 99%

The Circadian Syndrome: is the Metabolic Syndrome and much more!

Zimmet

Alberti

Stern³

et al. 2019

J Intern Med

222

192

View full text Add to dashboard Cite

show abstract

“…Therefore, energy intake at an inappropriate circadian time could lead to adverse metabolic dysfunction. Shift workers, i.e., individuals who are often awake at night and sleeping during the day, experience extreme circadian disruption and adverse meal timing, and shift workers have increased risk of metabolic dysfunction [10][11][12][13]. The majority of adults, however, are not shift workers-and therefore it is important to understand the degree to which meal timing is associated with metabolic function outside of extreme circadian disruption, such as shift work.…”

Section: Introductionmentioning

confidence: 99%

Association between Timing of Energy Intake and Insulin Sensitivity: A Cross-Sectional Study

et al. 2020

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In addition to the caloric and macronutrient composition of meals, timing of energy consumption may be important for optimal glucose metabolism. Our goal was to examine whether the habitual timing of energy intake was associated with insulin sensitivity in healthy volunteers. Volunteers without diabetes aged 21–50 years completed a 3-day food diary and underwent an oral glucose tolerance test to estimate insulin sensitivity (n = 44). From the food diary, we calculated the proportions of the total energy and macronutrients consumed in the morning and evening, and the clock time at which 25%, 50% and 75% of total energy was consumed. A greater proportion of energy intake in the morning was significantly associated with higher insulin sensitivity estimated by Matsuda Index (B = 2.8 per 10%; 95%CI: 0.3, 5.2). The time at which 25% of energy was consumed was associated with insulin sensitivity estimated by Matsuda Index (B = −1.6 per hour; 95%CI: −3.0, −0.3) and QUICKI (B = −1.4 per hour, 95%CI: −2.8, −0.1). The timing of carbohydrate consumption demonstrated similar associations. Greater energy intake earlier in the day was associated with higher insulin sensitivity in individuals without diabetes.

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“…Sleep disturbance has been linked to adverse health outcomes including cardiovascular disease, obesity, diabetes, depression, and anxiety, as well as safety issues related to drowsy driving and injuries (Kim et al, 2015 ; Shockey and Wheaton, 2017 ). By disrupting circadian rhythms, shift work has emerged as an important risk factor of many health outcomes (Gumenyuk et al, 2012 ; Wyse et al, 2017 ). Nocturnal shiftwork alters the rhythmicity of the immune system, and such a disruption might play a role in the increased infection risk and higher incidence of autoimmune diseases, cancer, and cardiovascular and metabolic disorders (Esquirol et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Exosomes and Metabolic Function in Mice Exposed to Alternating Dark-Light Cycles Mimicking Night Shift Work Schedules

et al. 2017

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Sleep is an important modulator of metabolic function. Disruptions of sleep in circadian rhythm are common in modern societies and are associated with increased risk of developing cardiometabolic disorders. Exosomes are ubiquitous extracellular vesicles that may play a mechanistic role in metabolic derangements. We hypothesized that alternating dark-light cycles mimicking shift work in mice would alter fecal microbiota and colonic epithelium permeability and alter plasma exosome cargo and metabolic function. C57BL/6 mice were randomly assigned to (i) control day light (CL), or (ii) inverted dark-light every 2 weeks for 8 weeks (IN). Body weight, fat mass and HOMA-IR were measured, along with Tregs, metabolic, and resident macrophages in visceral white adipose tissue (vWAT). Fecal water samples were incubated with confluent colonic epithelium cell cultures in electric cell-substrate impedance sensing (ECIS) arrays, and plasma exosomes were added to differentiated adipocytes and insulin-induced pAKT/AKT expression changes were assessed by western blots. Mice exposed to IN showed elevated HOMA-IR, and their fecal samples showed altered microbiota which promote increased permeability of the colonic epithelial cell barrier. Plasma exosomes decreased pAKT/AKT responses to exogenous insulin compared to CL, and altered expression of circadian clock genes. Inflammatory macrophages (Ly-6chigh) were increased in IN-exposed vWAT, while Tregs were decreased. Thus, gut microbiota and the cargo of plasma exosomes are altered by periodic shifts in environmental lighting, and effectively alter metabolic function, possibly via induction of systemic inflammation and altered clock expression in target tissues. Further exploration of exosomal miRNA signatures in shift workers and their putative metabolic organ cell targets appears warranted.

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Adverse metabolic and mental health outcomes associated with shiftwork in a population-based study of 277,168 workers in UK biobank

Cited by 81 publications

References 42 publications

The Circadian Syndrome: is the Metabolic Syndrome and much more!

The Circadian Syndrome: is the Metabolic Syndrome and much more!

Association between Timing of Energy Intake and Insulin Sensitivity: A Cross-Sectional Study

Exosomes and Metabolic Function in Mice Exposed to Alternating Dark-Light Cycles Mimicking Night Shift Work Schedules

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