Diffusion- and Perfusion-Weighted MRI Patterns in Borderzone Infarcts

Chaves, Claudia; Silver, Brian; Schlaug, Gottfried; Dashe, John F.; Caplan, Louis R.; Warach, Steve

doi:10.1161/01.str.31.5.1090

Cited by 60 publications

(36 citation statements)

References 36 publications

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“…ASSESSMENTS OF CHANGES in cerebral blood flow (CBF) by magnetic resonance imaging (MRI) can contribute significantly to the diagnosis of brain tumors (1), ischemic cerebrovascular disease (2), and epilepsy (3). During therapy, perfusion MRI can provide important information regarding the effectiveness of therapy, complications, and recurrent disease.…”

mentioning

confidence: 99%

FAIR‐TrueFISP imaging of cerebral perfusion in areas of high magnetic susceptibility differences at 1.5 and 3 Tesla

Boss

Martirosian

Klose

et al. 2007

Magnetic Resonance Imaging

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Purpose:To estimate cerebral blood perfusion in areas of strong magnetic susceptibility changes with high spatial and temporal resolution using a flow-sensitive alternating inversion recovery (FAIR) arterial spin labeling (ASL) method. Materials and Methods:We implemented an ASL method that is capable of imaging perfusion in areas of high magnetic susceptibility changes by combining a FAIR spin preparation with a true fast imaging in steady precession (TrueFISP) data acquisition strategy. A TrueFISP readout sequence was applied especially in regions with magnetic field inhomogeneities and compared with corresponding FAIR measurements obtained with a standard echo-planar imaging (EPI) readout. Quantitative perfusion images were obtained at 1.5 Tesla (1.5T) from eight healthy volunteers (24 -42 years old) and one patient (23 years old). FAIRTrueFISP perfusion images were compared with FAIR echoplanar images. T1 maps, which are necessary for quantitative perfusion estimation, were obtained with inversion recovery (IR) TrueFISP and IR EPI. Additionally, high-resolution perfusion measurements were performed on four volunteers at 3T. Results:The two ASL perfusion imaging modalities yielded comparable diagnostic image quality in brain areas with low susceptibility differences at 1.5T. Cerebral perfusion of gray matter (GM) areas was 105.7 Ϯ 5.2 mL/100 g/minute for FAIR-TrueFISP and 88.8 Ϯ 14.6 mL/100 g/minute for FAIR-EPI at 1.5T, and 70.4 Ϯ 7.1 mL/100 g/minute for FAIR-TrueFISP and 63.5 Ϯ 6.9 mL/100 g/minute for FAIR-EPI at 3.0T. Higher perfusion values at 1.5T were due to more pronounced partial-volume effects from fast moving spins at lower spatial resolution. The FAIR-TrueFISP sequence showed no significant distortions and markedly reduced signal void artifacts in areas of high susceptibility changes (e.g., near brain-bone transitions and close to metallic clips) compared to FAIR-EPI. At 3T, highly resolved FAIR-TrueFISP perfusion images were acquired with an in-plane resolution of up to 1.3 mm.Conclusion: FAIR-TrueFISP allows for assessment of cerebral perfusion in areas of critically high susceptibility changes with conventional ASL methods.

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mentioning

confidence: 99%

FAIR‐TrueFISP imaging of cerebral perfusion in areas of high magnetic susceptibility differences at 1.5 and 3 Tesla

Boss

Martirosian

Klose

et al. 2007

Magnetic Resonance Imaging

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“…Internal borderzone infarcts are thought to be attributable to hemodynamic compromise, 25 whereas external borderzone infarcts have been attributed to embolism not necessarily associated with hypoperfusion. 26,27 We observed both internal and external borderzone infarcts in patients with SLE without stenotic lesions on the relevant artery. Therefore, besides thromboembolism, different etiologies such as small-vessel injury may play a role in the development of borderzone infarcts.…”

Section: Bilateral Borderzone Infarctsmentioning

confidence: 80%

Brain MR Findings in Patients with Systemic Lupus Erythematosus with and without Antiphospholipid Antibody Syndrome

Kaichi

Kakeda²,

Moriya³

et al. 2013

AJNR Am J Neuroradiol

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“…35 Misery perfusion as characterized by the mismatch between critically reduced flow and sufficient oxygen supply (measured by the increase in oxygen extraction fraction) was observed in the parieto-occipital watershed area by positron emission tomography, and its reversal was documented after extra-intracranial arterial bypass surgery. 36 Since then the pathophysiology of watershed infarction was studied repeatedly mainly by positron emission tomography, 37 but hemodynamic compromise in the border zones was also evident in diffusion-and perfusionweighted magnetic resonance imaging 38 and in CBF studies by single photon emission tomography under acetazolamide challenge. 39 The risk for recurrent stroke in patients with major cerebral arterial occlusive disease is especially increased when oxygen extraction fraction was increased in the watershed region, 40,41 but selective neuronal damage may occur beyond the border zone infarctions within the areas of hemodynamic compromise.…”

Section: Neuroimagingmentioning

confidence: 99%